Dietary supplementation with <i>Allium hirtifolium</i> and/or <i>Astragalus hamosus</i> improved memory and reduced neuro-inflammation in the rat model of Alzheimer’s disease

Bahaeddin, Zahra; Yans, Asal; Khodagholi, Fariba; Sahranavard, Shamim

doi:10.1139/apnm-2017-0585

Cited by 13 publications

(6 citation statements)

References 53 publications

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“…This finding indicates that the presence of the other molecules in ARE is important to reduce the toxic effect of kaempferol without loss of its anti-aggregation and cell protection power. The recovery of viability of cells incubated with aggregates grown in the presence of ARE agrees with other studies indicating that protection by allium species extracts against the toxicity of Aβ 42 aggregates [31] is associated with their richness on phenolic and organosulfur compounds. Gupta et al [32] found that garlic extracts possess an anti-amyloidogenic activity, which can be affected by the extraction process.…”

Section: Discussionsupporting

confidence: 90%

Allium roseum L. extract inhibits amyloid beta aggregation and toxicity involved in Alzheimer’s disease

et al. 2020

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Allium roseum is an important medicinal and aromatic plant, specific to the North African flora and a rich source of important nutrients and bioactive molecules including flavonoids and organosulfur compounds whose biological activities and pharmacological properties are well known. In the present study, the inhibition of amyloid beta protein toxicity by the ethanolic extract of this plant is investigated for the first time. Preliminary biochemical analyses identified kaempferol and luteolin-7-o-glucoside as the more abundant phenolic compounds. The effects of A. roseum extract (ARE) on aggregation and aggregate cytotoxicity of amyloid beta-42 (Aβ 42), whose brain aggregates are a hallmark of Alzheimer's disease, were investigated by biophysical (ThT assay, Dynamic light scattering and transmission electron microscopy) and cellular assays (cytotoxicity, aggregate immunolocalization, ROS measurement and intracellular Ca 2+ imaging). The biophysical data suggest that ARE affects the structure of the Aβ 42 peptide, inhibits its polymerization, and interferes with the path of fibrillogenesis. The data with cultured cells shows that ARE reduces Aß 42 aggregate toxicity by inhibiting aggregate binding to the cell membrane and by decreasing both oxidative stress and intracellular Ca 2+. Accordingly, ARE could act as a neuroprotective factor against Aβ aggregate toxicity in Alzheimer's disease.

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Section: Discussionsupporting

confidence: 90%

Allium roseum L. extract inhibits amyloid beta aggregation and toxicity involved in Alzheimer’s disease

et al. 2020

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“…This finding indicates that the presence of the other molecules in ARE is important to reduce the toxic effect of kæmpferol without loss of its anti-aggregation and cell protection power. The recovery of viability of cells incubated with aggregates grown in the presence of ARE agrees with other studies indicating that protection by allium species extracts against the toxicity of Aβ 42 aggregates [31] is associated with their richness on phenolic and organosulfur compounds. Gupta, Indi [32] found that garlic extracts possess an anti-amyloidogenic activity, which can be affected by the extraction process.…”

Section: Discussionsupporting

confidence: 89%

Allium roseum L. extract inhibits amyloid beta aggregation and toxicity involved in Alzheimer’s disease

Boubakri

Leri

Bucciantini

et al. 2019

Preprint

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27Allium roseum is an important medicinal and aromatic plant, specific to the North African flora 28 and a rich source of important nutrients and bioactive molecules including flavonoids and 29 organosulfur compounds whose biological activities and pharmacological properties are well known. 30 In the present study, the inhibition of amyloid beta protein toxicity by the ethanolic extract of this 31 plant is investigated for the first time. Preliminary biochemical analyses identified kaempferol and 32 Luteolin-7-o-glucoside as the more abundant phenolic compounds. The effects of A. roseum extract 33 (ARE) on amyloid beta-42 (Aβ 42 ) aggregation and aggregate cytotoxicity, were investigated by 34 biophysical (ThT assay, Dynamic light scattering and transmission electron microscopy) and cellular 35 assays (cytotoxicity, aggregate immunolocalization, ROS measurement and intracellular 36Ca 2+ imaging). The biophysical data suggest that ARE affects the structure of Aβ 42 peptide, inhibits 37 its polymerization, and interferes with the path of fibrillogenesis. The data with cultured cells shows 38 that ARE reduces Aß 42 aggregate toxicity by inhibiting aggregate binding to the cell membrane and 39 by decreasing both oxidative stress and intracellular Ca 2+ . Accordingly, ARE could act as a 40 neuroprotective factor against Aβ aggregate toxicity in Alzheimer's disease. 41 42 Alzheimer's disease. 3 44 1. Introduction 45 Alzheimer's disease (AD), the main cause of senile dementia, is a progressive 46 neurodegenerative disorder associated with cognitive impairment and loss of neuronal cells affecting 47 over 25 million people worldwide [1], thus representing a heavy economic burden and a major health 48problem. The pathology is characterized by the accumulation in the brain of amyloid-β peptide (Aβ) 49 and hyperphosphorylated tau protein mainly found as extracellular senile plaques and intracellular 50 neurofibrillary tangles, respectively [2]. Aβ oligomers overproduction caused by mutations in APP 51 and presenilins [3, 4] appears to be directly associated to cognitive dysfunction and neurodegeneration 52 in AD [5]. Accordingly, toxic Aβ oligomers production and/or interaction with nerve cells appear 53 useful targets to reduce neuronal cell dysfunction. Feart, Samieri [6] suggest that in most cases AD is 54 affected by a combination of genetic and environmental risk factors, including physical activity and 55 nutrition; in particular, increasing evidence indicates that diet plays an important role in AD. Several 56 studies have associated plant food (i.e., vegetables, fruits, legumes, and cereals) consumption to 57 reduced risk of AD [7, 8]. Moreover, traditional medicine is increasingly appreciated as a useful 58 approach to treat many illnesses, and large funds are invested to explore the therapeutic potential of 59 medicinal plants. Fortunately, the search of active compounds from nature prospers and the results 60 increasingly obtained confirm the need to better known the therapeutic potential of these natur...

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“…It is mainly caused by aging and apoptosis of nerve cells affected by internal and external environmental factors, and a large amount of degeneration and loss of dopaminergic neurons. AD mainly occurs in the elderly at the age of >65 years and is manifested as memory loss and cognitive problems resulting in serious inconvenience of their daily lives ( 1 , 2 ). In Europe, the United States and other countries, AD is a major neurological disease that causes the death of the elderly.…”

Section: Introductionmentioning

confidence: 99%

Anti‑inflammatory effects of bone marrow mesenchymal stem cells on mice with Alzheimer's disease

Yan

Xie

et al. 2018

Exp Ther Med

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Anti-inflammatory effects of bone marrow mesenchymal stem cells (BMSCs) on mice with Alzheimer's disease (AD) were investigated. Twenty amyloid precursor protein (APP)/presenilin-1 (PS1) double transgenic mice were randomly divided into two groups: the AD control group and the stem cell treatment group. The normal control group consisted of 10 non-transgenic mice. The stem cell treatment group was injected with BMSCs, and the two control groups were given the same volume of normal saline. The Morris water maze test was used to compare the memory function of mice, and the relative expression levels of β-site APP cleaving enzyme 1 (BACE1) and α-2-macroglobulin (A2M) genes were detected by fluorescence quantitative polymerase chain reaction (qPCR). Amyloid β (Aβ)1–42 content in brain tissues of mice and inflammatory cytokines, interleukin (IL)-1, IL-2, IL-10, tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) were detected using enzyme-linked immunosorbent assay (ELISA). Compared with that in the AD control group, the escape latency in the water maze in the stem cell treatment group was shortened, the time of crossing the ring for the first time was decreased, but the frequency of crossing the ring was increased (P<0.05). Aβ1–42 content in the AD control group was higher than that in the stem cell treatment group and the normal control group (P<0.05). The relative expression level of BACE1 gene in the stem cell treatment group was lower than that in the AD control group (P<0.05), but that of A2M gene was increased (P<0.05). At 14 days after treatment, the contents of IL-1, IL-2, TNF-α and IFN-γ in blood in the stem cell treatment group were lower than those in the AD control group (P<0.05). Human BMSCs can ameliorate the symptoms of AD by decreasing the levels of inflammatory cytokines and regulating the expression of Aβ-related genes.

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Dietary supplementation with Allium hirtifolium and/or Astragalus hamosus improved memory and reduced neuro-inflammation in the rat model of Alzheimer’s disease

Cited by 13 publications

References 53 publications

Allium roseum L. extract inhibits amyloid beta aggregation and toxicity involved in Alzheimer’s disease

Allium roseum L. extract inhibits amyloid beta aggregation and toxicity involved in Alzheimer’s disease

Allium roseum L. extract inhibits amyloid beta aggregation and toxicity involved in Alzheimer’s disease

Anti‑inflammatory effects of bone marrow mesenchymal stem cells on mice with Alzheimer's disease

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