Dietary tartary buckwheat intake attenuates insulin resistance and improves lipid profiles in patients with type 2 diabetes: a randomized controlled trial

Qiu, Ju; Liu, Yan-Ping; Yue, Yanfen; Qin, Yuchang; Li, Zaigui

doi:10.1016/j.nutres.2016.11.007

Cited by 57 publications

(36 citation statements)

References 25 publications

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“…Plasma glucose, HbA1c, serum insulin, and the homeostasis model of assessment insulin resistance (HOMA-IR) were measured according to our pervious methods. 21 Serum glycated albumin (GA) was measured using the LUCICA GA-L kit (Asahi Kasei Pharma Corporation, Tokyo, Japan) and analyzed by the automated ADVIA 1650 instrument (Siemens Medical Solutions Diagnostics, Tarrytown, NY, USA). Plasma tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were measured using the enzyme-linked immunosorbent assay technique from R&D Systems (Minneapolis, MN, USA).…”

Section: Methodsmentioning

confidence: 99%

Dietary black-grained wheat intake improves glycemic control and inflammatory profile in patients with type 2 diabetes: a randomized controlled trial

Liu¹,

Qiu²,

Yue³

et al. 2018

TCRM

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IntroductionAlthough black-grained wheat (BGW) is recognized as a nutritional food for humans in China, it has yet to be utilized well for industrial applications, which can be attributed to the limited research data available on its health benefits. Thus, the hypothesis was tested that a daily substitution of BGW for a partial staple food would improve glycemia and inflammatory profile of type 2 diabetes mellitus (T2DM) patients by a randomized controlled trial.Materials and methodsA total of 120 patients were randomly divided between control group (diet control and nutritional education) and BGW group (daily substitution of BGW for a partial staple food).ResultsBased on the significant difference between BGW and control groups (P<0.05), the primary outcomes were that BGW treatment in diet resulted in a significant lowering of glycated albumin (GA, 18.05 to 16.06 mmol/L) level in T2DM patients after a 5-week intervention, and this treatment regimen was much more efficient than the strategy of diet control alone. In addition, BGW supplementation prevented the increase in tumor necrosis factor (TNF)-α and interleukin (IL)-6 induced by T2DM. There were no significant differences in blood glucose, glycated hemoglobin or insulin levels between the 2 groups. The subgroup analyses of the BGW daily intake showed that, except the TNF-α, significant improvements in GA and IL-6 were observed when the BGW intake dose was >69 g/day.ConclusionThese findings support the hypothesis that BGW may improve glycemia and the inflammatory profile in T2DM patients.

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Section: Methodsmentioning

confidence: 99%

Dietary black-grained wheat intake improves glycemic control and inflammatory profile in patients with type 2 diabetes: a randomized controlled trial

Liu¹,

Qiu²,

Yue³

et al. 2018

TCRM

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“…It has attracted increasing attention from food scientists as a potentially important functional food source because of its bioactive components and multiple health benefits (Ahmed et al, 2013). It contains proteins with high biological value and a balanced amino acid composition, highly resistant starch and dietary fibre (Qiu et al, 2016). Tartary buckwheat is not only a nutritionally valuable food material, but also a healthy plant food (Qin et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Effect of milling method on the chemical composition and antioxidant capacity of Tartary buckwheat flour

Liu

Wang

et al. 2018

Int J of Food Sci Tech

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Summary Tartary buckwheat has attracted increasing attention as a potentially functional food source because of its bioactive components and health benefits. However, little information is available concerning the effect of different milling methods (ultrafine milling (UM), roller milling (RM), stone milling (SM) and wet milling (WM)) on the chemical composition and antioxidant capacity of Tartary buckwheat flour. UM had an important role in reducing the average particle size and in brightening the colour of flour. SM and UM flour exhibited the largest amounts of crude protein, fibre and minerals. WM flour had the lowest moisture content. Rutin was the dominant phenolic compound in UM flour, SM flour and RM flour, whereas quercetin was the most abundant phenolic compound in WM flour. UM flour and SM flour contained higher total phenolic content and antioxidant activity as compared with those of RM flour and WM flour.

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“…Type II diabetes (T2D), hypertension (HT) and hyperlipidemia (HL) are three major diseases with a high incidence in modern society, which have seriously damaged human health. TB has been reported to have the ability to decrease the risk of type 2 diabetes mellitus (T2DM) ( Lee et al, 2012 ; Zhang et al, 2012 ); research on TB has indicated that dietary Tartary buckwheat intake attenuates insulin resistance and improves lipid profiles in patients with T2D ( Qiu et al, 2016 ). A diet that includes TB can also reduce the blood sugar levels of patients with T2D, demonstrating that TB can contribute to the effective control of T2D ( Lee et al, 2016 ; Zhou et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

“…TB has been demonstrated that insulin resistance was attenuated and that lipid profiles was also ameliorated in patients with T2D after dieting TB (>110 g/d) for four weeks ( Qiu et al, 2016 ). A research on 75% ethanol extract of TB (EETB) and rutin demonstrated that both EETB and rutin suppresses the formation of fructosamine and α-dicarbonyl compounds to lower the level of AGEs (advanced glycation end-products).…”

Section: Introductionmentioning

confidence: 99%

Uncovering the relationship and mechanisms of Tartary buckwheat (Fagopyrum tataricum) and Type II diabetes, hypertension, and hyperlipidemia using a network pharmacology approach

Zheng

Shen

et al. 2017

PeerJ

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BackgroundTartary buckwheat (TB), a crop rich in protein, dietary fiber, and flavonoids, has been reported to have an effect on Type II diabetes (T2D), hypertension (HT), and hyperlipidemia (HL). However, limited information is available about the relationship between Tartary buckwheat and these three diseases. The mechanisms of how TB impacts these diseases are still unclear.MethodsIn this study, network pharmacology was used to investigate the relationship between the herb as well as the diseases and the mechanisms of how TB might impact these diseases.ResultsA total of 97 putative targets of 20 compounds found in TB were obtained. Then, an interaction network of 97 putative targets for these compounds and known therapeutic targets for the treatment of the three diseases was constructed. Based on the constructed network, 28 major nodes were identified as the key targets of TB due to their importance in network topology. The targets of ATK2, IKBKB, RAF1, CHUK, TNF, JUN, and PRKCA were mainly involved in fluid shear stress and the atherosclerosis and PI3K-Akt signaling pathways. Finally, molecular docking simulation showed that 174 pairs of chemical components and the corresponding key targets had strong binding efficiencies.ConclusionFor the first time, a comprehensive systemic approach integrating drug target prediction, network analysis, and molecular docking simulation was developed to reveal the relationships and mechanisms between the putative targets in TB and T2D, HT, and HL.

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Dietary tartary buckwheat intake attenuates insulin resistance and improves lipid profiles in patients with type 2 diabetes: a randomized controlled trial

Cited by 57 publications

References 25 publications

Dietary black-grained wheat intake improves glycemic control and inflammatory profile in patients with type 2 diabetes: a randomized controlled trial

Dietary black-grained wheat intake improves glycemic control and inflammatory profile in patients with type 2 diabetes: a randomized controlled trial

Effect of milling method on the chemical composition and antioxidant capacity of Tartary buckwheat flour

Uncovering the relationship and mechanisms of Tartary buckwheat (Fagopyrum tataricum) and Type II diabetes, hypertension, and hyperlipidemia using a network pharmacology approach

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