Dietary Tomato Consumption and the Risk of Prostate Cancer: A Meta-Analysis

Abstract

Objective: Several epidemiological studies have linked tomato products consumption with prostate cancer risk; however, the findings yielded inconsistent results. The aim of the present meta-analysis is to summary the evidence on this association based on eligible cohort studies.Materials and Methods: A comprehensive literature search of articles was performed in March 2021 using PubMed, ISI Web of Science, and Scopus databases. A random-effects model was used to calculate the combined relative risks (RRs) and their corresponding 95% confidence intervals (CIs). Heterogeneity across studies was assessed using Cochran's Q statistic and the I2 score.Results: A total of 10 prospective studies were finally included in our meta-analysis. There was no evidence of a significant association between tomato products consumption and prostate cancer risk (RR 0.91, 95% CI 0.79–1.03, P = 0.138). Subgroup meta-analyses were performed by tomato types, geographical region, publication year, study quality and number of cases. No significant associations were observed in any subgroups (all P > 0.05). No significant publication bias was observed using Begg's test (P = 0.602) or Egger's test (P = 0.957).Conclusion: The results of this meta-analysis indicated that tomato consumption was not related with the risk of prostate cancer. Further prospective large-scale cohort studies are still warranted to verify our findings.

Association between Tomato and Lycopene Consumption and Risk of All‐Cause and Cause‐Specific Mortality: Korean Genome and Epidemiology Study Cohort

“…[13] Furthermore, tomato consumption exhibited an inverse relationship with certain types of cancers such as gastric cancer [36] and hepatocellular carcinoma. [37] However, in the meta-analysis for tomato consumption and prostate cancer in the Western population, dietary tomato consumption was not associated with the risk of prostate cancer, [38] and tomato consumption was not significantly related to the risk of bladder cancer. [39] Previous studies with the cohort of the US National Health and Nutrition Examination Survey (NHANES) and Prostate, Lung, Colorectal, and Ovarian screening trial reported an inverse asso-ciation of tomato and lycopene consumption with risk of all-cause and CVD mortality.…”

“…[ 13 ] Furthermore, tomato consumption exhibited an inverse relationship with certain types of cancers such as gastric cancer [ 36 ] and hepatocellular carcinoma. [ 37 ] However, in the meta‐analysis for tomato consumption and prostate cancer in the Western population, dietary tomato consumption was not associated with the risk of prostate cancer, [ 38 ] and tomato consumption was not significantly related to the risk of bladder cancer. [ 39 ]…”