Dietary total antioxidant capacity is inversely related to menopausal symptoms: a cross-sectional study among Iranian postmenopausal women

Abshirini, Maryam; Siassi, Fereydoun; Koohdani, Fariba; Qorbani, Mostafa; Khosravi, Shahla; Hedayati, Mehdi; Aslani, Zahra; Soleymani, Mahshid; Sotoudeh, Gity

doi:10.1016/j.nut.2018.04.014

Cited by 27 publications

(14 citation statements)

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“…The details of the study procedure have been described previously [ 20 ]. In brief, subjects were 175 postmenopausal women that postmenopausal status identified by an absence of a menstrual cycle for at least 1 year.…”

Section: Methodsmentioning

confidence: 99%

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Dietary total antioxidant capacity is inversely associated with depression, anxiety and some oxidative stress biomarkers in postmenopausal women: a cross-sectional study

et al. 2019

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BackgroundPostmenopausal women are at higher risk of mental disorders. Oxidative stress has implication in the development of these disorders. Dietary total antioxidant capacity (DTAC) has been proposed as a tool for assessing dietary antioxidants intake. The relationship between DTAC with depression, anxiety and stress has not been investigated in postmenopausal women. Thus, we aimed to assess the association between DTAC and depression, stress and anxiety as well as oxidative stress biomarkers.MethodsThis cross-sectional study was carried out on 175 postmenopausal women. Data on dietary intake and mental health were collected by 147-item semi-quantitative food frequency questionnaires (FFQ) and Depression Anxiety Stress Scales (DASS-42), respectively. Dietary and serum total antioxidant capacity (TAC), malondialdehyde (MDA), oxidized-LDL, and superoxide dismutase (SOD) were measured. ANOVA test was applied to compare the mean of variables across the tertiles of DTAC. The relationship between DTAC and oxidative stress biomarkers was determined through ANCOVA method. Simple and multivariate linear regression tests were performed to measure the relationship between DTAC and mental health.ResultsSerum MDA level was significantly lower in the subjects at the highest tertiles of DTAC (P-value < 0.001). In addition, serum TAC level was significantly higher in subjects at the second tertile of DTAC (P-value = 0.04). DTAC was inversely and independently related to depression (β = − 0.16, P-value = 0.03) and anxiety scores (β = − 0.21, P-value = 0.007). There was no significant association between DTAC and stress score (β = − 0.10, P-value = 0.1).ConclusionAn inverse relationship was found between DTAC with depression, anxiety scores and some oxidative stress biomarkers in postmenopausal women. These findings indicate DTAC may be used for developing effective dietary measures for reducing depression and anxiety in these women.

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Section: Methodsmentioning

confidence: 99%

“…DTAC was calculated by summing the individual dietary antioxidant capacities based on the oxygen radical absorbance capacity (ORAC) as described in our previous studies [ 20 , 22 ]. The DTAC values of the individuals were reported as micromole of Trolox Equivalents per day (µmol TE/day).…”

Section: Methodsmentioning

confidence: 99%

Dietary total antioxidant capacity is inversely associated with depression, anxiety and some oxidative stress biomarkers in postmenopausal women: a cross-sectional study

et al. 2019

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“…Regarding the effect of the antioxidant potential of diet on sleep, one study in postmenopausal women in Iran found that a higher dietary total antioxidant capacity (TAC), a tool for assessment of healthy effects of dietary antioxidants and estimated by measuring the oxygen radical absorbance capacity (ORAC) of selected foods, was associated with a reduction in sleep problems and other menopausal symptoms [ 131 ]. Another Iranian study in diabetic women confirmed that a higher dietary TAC, based on the ferric reducing ability of plasma (FRAP) and ORAC databases, was related with a lower risk of poor sleep and psychological disorders [ 132 ].…”

Section: Potential Mechanisms Underlying the Mediterranean Diet Effec...mentioning

confidence: 99%

Mediterranean Diet on Sleep: A Health Alliance

2022

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The Mediterranean diet is a plant-based, antioxidant-rich, unsaturated fat dietary pattern that has been consistently associated with lower rates of noncommunicable diseases and total mortality, so that it is considered one of the healthiest dietary patterns. Clinical trials and mechanistic studies have demonstrated that the Mediterranean diet and its peculiar foods and nutrients exert beneficial effects against inflammation, oxidative stress, dysmetabolism, vascular dysfunction, adiposity, senescence, cognitive decline, neurodegeneration, and tumorigenesis, thus preventing age-associated chronic diseases and improving wellbeing and health. Nocturnal sleep is an essential physiological function, whose alteration is associated with health outcomes and chronic diseases. Scientific evidence suggests that diet and sleep are related in a bidirectional relationship, and the understanding of this association is important given their role in disease prevention. In this review, we surveyed the literature concerning the current state of evidence from epidemiological studies on the impact of the Mediterranean diet on nighttime sleep quantity and quality. The available studies indicate that greater adherence to the Mediterranean diet is associated with adequate sleep duration and with several indicators of better sleep quality. Potential mechanisms mediating the effect of the Mediterranean diet and its foods and nutrients on sleep are described, and gap-in-knowledge and new research agenda to corroborate findings are discussed.

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“…Thus, the dietary concept which takes the whole dietary antioxidants into account has become more prominent. Dietary total antioxidant capacity (DTAC) is a novel indicator of diet quality [40], which is used to estimate the cumulative power of antioxidants in the whole diet [41]. Recently, DTAC is described as an effective tool for determining the health outcomes in populations [42,43].…”

Section: Discussionmentioning

confidence: 99%

Association between Serum Uric Acid Levels, Nutritional and Antioxidant Status in Patients on Hemodialysis

et al. 2020

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Purpose: To determine the relationship between uric acid (UA) and nutritional and antioxidant status in hemodialysis (HD) patients, given that hyperuricemia could be an indicator of good nutritional status possibly because of the antioxidant properties of UA. Methods: Cross-sectional study with 93 patients on HD. Hyperuricemia was considered as UA ≥6.0 mg/dL in females and ≥7.0 mg/dL in males. Nutritional variables were registered. Blood samples were taken before the dialysis session to determine oxidative damage as plasma malondialdehyde (MDA) content, and antioxidant capacity measuring 2,2-diphenyl-piclrylhidrazil radical (DPPH●) scavenging activity and oxygen radical absorbance capacity (ORAC) value. Results: Patients with hyperuricemia had higher creatinine (11.9 vs. 10.5 mg/dL; p = 0.004), potassium (5.5 vs. 5.0 mg/dL; p = 0.014) levels; phase angle (5.8 vs. 4.9; p = 0.005), protein consumption (normalized protein nitrogen appearance, nPNA, 1.03 vs. 0.83; p = 0.013) than normouricemic patients. DPPH● scavenging activity was higher in hyperuricemic subjects (1.139 vs. 1.049 mM Trolox equivalents; p = 0.007); likewise, hyperuricemic subjects had less oxidant damage measured by MDA (10.6 vs. 12.7 nmol/mL; p = 0.020). Subjects with normouricemia were at higher risk of having a reactance to height (Xc/H) ratio less than 35 (OR 2.79; 95% CI, 1.1–7.017, p = 0.028); nPNA < 1.0 (OR 3.78; 95% CI, 1.4–10.2, p = 0.007), diagnosis of cachexia (OR 2.95; 95% CI, 1156–7.518, p = 0.021), potassium levels <5 (OR 2.97; 95% CI, 1.136–7.772, p = 0.023) and PA < 5.5° (OR 3.38; 95% CI, 1.309–8.749, p = 0.012.) Conclusions: Patients with hyperuricemia had higher antioxidant capacity and better nutritional status. Purines and protein restrictions in HD patients with hyperuricemia need to be reviewed individually for each patient. More studies are needed to stablish a cut point of UA levels in renal population.

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Dietary total antioxidant capacity is inversely related to menopausal symptoms: a cross-sectional study among Iranian postmenopausal women

Cited by 27 publications

References 46 publications

Dietary total antioxidant capacity is inversely associated with depression, anxiety and some oxidative stress biomarkers in postmenopausal women: a cross-sectional study

Dietary total antioxidant capacity is inversely associated with depression, anxiety and some oxidative stress biomarkers in postmenopausal women: a cross-sectional study

Mediterranean Diet on Sleep: A Health Alliance

Association between Serum Uric Acid Levels, Nutritional and Antioxidant Status in Patients on Hemodialysis

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