Dietary vitamin D dose-response in healthy children 2 to 8 y of age: a 12-wk randomized controlled trial using fortified foods

Brett, Neil R.; Lavery, Paula; Agellon, Sherry; Vanstone, Catherine A.; Maguire, Jonathon L.; Rauch, Frank; Weiler, Hope A.

doi:10.3945/ajcn.115.115956

Cited by 34 publications

(61 citation statements)

References 32 publications

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“…Although we had adequate power to detect the described interaction between 25(OH)D and VDR, other genetic interactions of smaller magnitude might be missed here and would require even larger studies for detection. We were not able to examine the association between IA and vitamin D deficiency, as only 6% of the children in our nested case-control study were vitamin D deficient, as defined by average childhood 25 and children via vitamin D supplementation (51) or dietary modification (52) have been successful in attaining vitamin D sufficiency. Whether or not these efforts should target children who have specific variants in the VDR gene requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity

et al. 2017

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We examined the association between plasma 25-hydroxyvitamin D [25(OH)D] concentration and islet autoimmunity (IA) and whether vitamin D gene polymorphisms modify the effect of 25(OH)D on IA risk. We followed 8,676 children at increased genetic risk of type 1 diabetes at six sites in the U.S. and Europe. We defined IA as positivity for at least one autoantibody (GADA, IAA, or IA-2A) on two or more visits. We conducted a risk set sampled nested case-control study of 376 IA case subjects and up to 3 control subjects per case subject. 25(OH)D concentration was measured on all samples prior to, and including, the first IA positive visit. Nine polymorphisms in , and were analyzed as effect modifiers of 25(OH)D. Adjusting for HLA-DR-DQ and ancestry, higher childhood 25(OH)D was associated with lower IA risk (odds ratio = 0.93 for a 5 nmol/L difference; 95% CI 0.89, 0.97). Moreover, this association was modified by rs7975232 (interaction = 0.0072), where increased childhood 25(OH)D was associated with a decreasing IA risk based upon number of minor alleles: 0 (1.00; 0.93, 1.07), 1 (0.92; 0.89, 0.96), and 2 (0.86; 0.80, 0.92). Vitamin D and may have a combined role in IA development in children at increased genetic risk for type 1 diabetes.

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Section: Discussionmentioning

confidence: 99%

Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity

et al. 2017

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“…After 12 months of age, the IOM recommends an intake of 600 IU/day (RDA) for children, adolescents, and adults through supplementation or fortified foods, assuming minimal endogenous production from sunlight exposure. These intakes are likely sufficient to maintain 25(OH)D concentrations above 50 nmol/L in most healthy children, thereby essentially preventing rickets. IOM recommendations for women of childbearing age, including during pregnancy, are the same as the general recommendations for adults (600 IU/day).…”

Section: Consequences Of Vitamin D Deficiencymentioning

confidence: 99%

Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low‐ and middle‐income countries

Roth

Abrams

Aloia

et al. 2018

Annals of the New York Academy of Sciences

415

340

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Vitamin D is an essential nutrient for bone health and may influence the risks of respiratory illness, adverse pregnancy outcomes, and chronic diseases of adulthood. Because many countries have a relatively low supply of foods rich in vitamin D and inadequate exposure to natural ultraviolet B (UVB) radiation from sunlight, an important proportion of the global population is at risk of vitamin D deficiency. There is general agreement that the minimum serum/plasma 25-hydroxyvitamin D concentration (25(OH)D) that protects against vitamin D deficiency-related bone disease is approximately 30 nmol/L; therefore, this threshold is suitable to define vitamin D deficiency in population surveys. However, efforts to assess the vitamin D status of populations in low- and middle-income countries have been hampered by limited availability of population-representative 25(OH)D data, particularly among population subgroups most vulnerable to the skeletal and potential extraskeletal consequences of low vitamin D status, namely exclusively breastfed infants, children, adolescents, pregnant and lactating women, and the elderly. In the absence of 25(OH)D data, identification of communities that would benefit from public health interventions to improve vitamin D status may require proxy indicators of the population risk of vitamin D deficiency, such as the prevalence of rickets or metrics of usual UVB exposure. If a high prevalence of vitamin D deficiency is identified (>20% prevalence of 25(OH)D < 30 nmol/L) or the risk for vitamin D deficiency is determined to be high based on proxy indicators (e.g., prevalence of rickets >1%), food fortification and/or targeted vitamin D supplementation policies can be implemented to reduce the burden of vitamin D deficiency-related conditions in vulnerable populations.

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“…Likewise, as it is a fat-soluble vitamin, vitamin D deficit has also been related to obesity due to the fact that it is stored in fatty tissue, of which these patients have a large volume and more supply is needed to fill the deposits [ 29 ]. Its deficit, therefore, is associated to diabetes mellitus (types 1 and 2) due to beta cell dysfunction, with a reduction of secretion and an increase of insulin resistance [ 30 ].…”

Section: Main Textmentioning

confidence: 99%

Vitamin D levels in a pediatric population of a primary care centre: a public health problem?

et al. 2018

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ObjectiveVitamin D deficiency is a public health problem that occurs more frequently than expected. The aim of this study is to evaluate the vitamin D levels of children attending the paediatrics unit of the Bertamiráns primary care centre (A Coruña NW Spain). This is an observational study carried out during 1 year on a random sample of the pediatric population aged between 5 and 15 years. The levels of vitamin D (25(OH)D) were determined by immunoassay (ADVIA Centaur Vitamin D®). The results were classified as sufficient (> 20 ng/ml), insufficient (10–20 ng/ml) and deficient (< 10 ng/ml).Results153 analyses of vitamin D were carried out (58.2% in girls and 41.8% in boys), distributed in two age groups: 5–10 (62) and 10–15 (91). 66% of the total of the sample presented some degree of vitamin D deficit (60.1% insufficient (92) and 5.9% (11) deficient). In Galicia, there is a high prevalence of vitamin D deficiency/insufficiency in the healthy population, which increases if the patients present some kind of chronic pathology, thus leading to a public health problem. It is advisable to increase the consumption of fortified foods and/or to reconsider the administration of vitamin supplements.Electronic supplementary materialThe online version of this article (10.1186/s13104-018-3903-7) contains supplementary material, which is available to authorized users.

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Dietary vitamin D dose-response in healthy children 2 to 8 y of age: a 12-wk randomized controlled trial using fortified foods

Cited by 34 publications

References 32 publications

Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity

Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity

Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low‐ and middle‐income countries

Vitamin D levels in a pediatric population of a primary care centre: a public health problem?

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