Dietary vitamin E and C intake is inversely associated with the severity of nonalcoholic fatty liver disease

Ivancovsky‐Wajcman, Dana; Fliss-Isakov, Naomi; Salomone, Federico; Webb, Muriel; Shibolet, Oren; Kariv, Revital; Zelber‐Sagi, Shira

doi:10.1016/j.dld.2019.06.005

Cited by 65 publications

(54 citation statements)

References 41 publications

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“…The intake of orange juice, a source of flavonoids and vitamin C, for eight weeks, resulted in a reduction of total cholesterol, LDL-cholesterol, C reactive protein, and oxidative stress related markers, in a randomized study of 43 chronic hepatitis C patients [111]. Dietary vitamin C intake was shown to be inversely correlated with the presence of NAFLD, similarly to vitamin E, suggesting the favorable effect of both vitamins [112]. The positive effect of the intake of vitamin C on NAFLD prevention was shown to be dominant in middle-aged, non-obese males [113].…”

Section: Dietary Intervention For Oxidative Stressmentioning

confidence: 98%

Oxidative Stress Management in Chronic Liver Diseases and Hepatocellular Carcinoma

et al. 2020

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Chronic viral hepatitis B and C and non-alcoholic fatty liver disease (NAFLD) have been widely acknowledged to be the leading causes of liver cirrhosis and hepatocellular carcinoma. As anti-viral treatment progresses, the impact of NAFLD is increasing. NAFLD can coexist with chronic viral hepatitis and exacerbate its progression. Oxidative stress has been recognized as a chronic liver disease progression-related and cancer-initiating stress response. However, there are still many unresolved issues concerning oxidative stress, such as the correlation between the natural history of the disease and promising treatment protocols. Recent findings indicate that oxidative stress is also an anti-cancer response that is necessary to kill cancer cells. Oxidative stress might therefore be a cancer-initiating response that should be down regulated in the pre-cancerous stage in patients with risk factors for cancer, while it is an anti-cancer cell response that should not be down regulated in the post-cancerous stage, especially in patients using anti-cancer agents. Antioxidant nutrients should be administered carefully according to the patients’ disease status. In this review, we will highlight these paradoxical effects of oxidative stress in chronic liver diseases, pre- and post-carcinogenesis.

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Section: Dietary Intervention For Oxidative Stressmentioning

confidence: 98%

Oxidative Stress Management in Chronic Liver Diseases and Hepatocellular Carcinoma

et al. 2020

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“…One of the diet components that can affect these symptoms is the natural antioxidant. Interventional studies using antioxidant supplements (vitamins C and E) have shown that supplementation with antioxidants may include positive effects on these symptoms and diseases (10) . However, the assessment of an antioxidant compound alone cannot reflect total antioxidant potency of the diet and reflects the synergistic and potential effects of dietary antioxidant interactions.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, the term of dietary total antioxidant capacity (DTAC) has been developed as an appropriate tool to assess effects of dietary antioxidants. This includes a strong correlation with serum TAC (10) and is closely linked to the quality of diets to assess risks of chronic diseases (11) .…”

Section: Introductionmentioning

confidence: 99%

Associations between dietary total antioxidant capacity and odds of non-alcoholic fatty liver disease (NAFLD) in adults: a case–control study

et al. 2020

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The relationships between the total antioxidant capacity (TAC) of the diet and the risk of non-alcoholic fatty liver disease (NAFLD) have not previously been assessed. The aim of this study was to assess relationships between DTAC and odds of NAFLD in a case–control study. This case–control study was carried out in 158 patients with NAFLD and 357 healthy individuals aged 18–55 years. Dietary data were collected using validated 168-item quantitative food frequency questionnaires. Triacylglycerols (TAGs), total cholesterol (TC), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C) and fasting blood glucose (FBS) concentrations were assessed using enzymatic methods and commercial kits. The DTAC was calculated based on the oxygen radical absorbance capacity of each food reported by the U.S. Department of Agriculture. The mean ± sd (standard deviation) for age and body mass index (BMI) of the study participants were 43⋅9 years ±5⋅9 and had 30⋅5 kg/m2 ±2⋅6. The NAFLD patients included higher BMI and female proportion, compared with the control group. The NAFLD patients included higher smoking rates, biochemical parameters (TG, TC, LDL-C and FBS) and DTAC scores, compared with control groups (P-value < 0⋅05). However, patients with NAFLD had lower HDL levels and physical activities, compared with the control group. The highest tertile of DTAC showed lower odds of NAFLD, compared with the lowest tertile. This association was significant after adjustment for potential confounders (OR, 0⋅19; 95 % CI, 0⋅9–0⋅34; P for trend 0⋅001). Findings suggest that the promotion of naturally increased antioxidant capacities may help prevent odds of NAFLD.

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“…Ivanovski Wajcman D and co-workers divided 789 subjects into two groups according to NAFLD and NASH medical evaluation. After vitamin E and C administration, hepatic protective effects were observed [46].…”

Section: Resultsmentioning

confidence: 99%

Hypercaloric Diet and Vitamin E Intake

Radulescu¹,

Miricescu²,

Totan³

et al. 2019

Mat.Plast.

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PLGA (poly-lactic-co-glycolic acid) nanoparticles represent an important synthetic biocomponent that has the potential to be a promising carrier of drugs, proteins, nucleic acids, due to its biodegradability and minimal side effects. The aim of our study was to observe the antioxidant effect of vitamin E loaded in PLGA nanoparticles administered over a period of 3 weeks in Wistar rats treated with a hypercaloric diet. Glutathione (GSH) and malondiadehyde (MDA) biomarkers determined from liver lysate were analyzed to evaluate the oxidative stress (OS) induced by the hypercaloric diet. The results of our study revealed a statistically significant increase for GSH and vitamin E in group 2 of Wistar rats receiving hypercaloric diet and a daily dose of vitamin E versus group 1 (p[0.005). The antioxidant effect of vitamin E was also observed by the statistically significant decrease of MDA in group 2 of Wistar rats compared with group 1. The daily dose of vitamin E has improved the liver redox status of group 2 Wistar rats.

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Dietary vitamin E and C intake is inversely associated with the severity of nonalcoholic fatty liver disease

Cited by 65 publications

References 41 publications

Oxidative Stress Management in Chronic Liver Diseases and Hepatocellular Carcinoma

Oxidative Stress Management in Chronic Liver Diseases and Hepatocellular Carcinoma

Associations between dietary total antioxidant capacity and odds of non-alcoholic fatty liver disease (NAFLD) in adults: a case–control study

Hypercaloric Diet and Vitamin E Intake

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