Dietary Zinc, Copper, and Selenium Intake and High-Risk Human Papillomavirus Infection among American Women: Data from NHANES 2011–2016

Abstract

Studies have shown that the micronutrients, zinc (Zn), copper (Cu), and selenium (Se) are associated with the HPV-associated cervical cancer, yet between dietary Zn/Cu/Se intake and high-risk HPV (hrHPV) infection remain unclear. We obtained publicly available data in the present cross-sectional study from the National Health and Nutrition Examination Survey (NHANES) performed between 2011 and 2016. Dietary Zn, Cu, and Se intakes were assessed from two 24-h diet recalls. A total of 4628 female with the age of 18-59 years were included in this secondary analysis. Comparing the highest with the lowest quartiles of Zn intake, the adjusted odds ratio (aOR) for hrHPV infection was 0.72 (95% CI, 0.54-0.98). The aOR upon comparison of the quartile three with the lowest quartile of Cu intake was 0.67 (95% CI, 0.50-0.90). Whereas no significant association was found between intakes of Se and hrHPV infection in multivariate analysis. Moreover, compared with those below the Recommended Dietary Allowance (RDA), hrHPV infection risk was significantly decreased among women who met the RDA for Cu (aOR: 0.74; 95% CI = 0.60-0.92), but not for Zn and Se. In conclusion, high dietary Zn and moderate copper intakes were independently and negatively associated with hrHPV infection in addition to Se.

Changes of urinary proteome in rats after intragastric administration of zinc gluconate

“…Chronic zinc deficiency leads to a marked reduction in cell-mediated immunity, antibody response and antibody affinity, complement system and phagocytic activity [73] . High dietary zinc is negatively associated with high-risk HPV (hrHPV) infection [74] . In neuronal cells, zinc deficiency induces oxidative stress and alters the normal structure and dynamics of the cytoskeleton [75] .…”

“…The copyright holder for this preprint this version posted March 6, 2024. ; https://doi.org/10.1101/2024.03.04.583149 doi: bioRxiv preprint is negatively associated with high-risk HPV (hrHPV) infection [74] . In neuronal cells, zinc deficiency induces oxidative stress and alters the normal structure and dynamics of the cytoskeleton [75] .…”

The association between intakes of dietary trace minerals and gallstone disease: A cross-sectional study from National Health and Nutrition Examination Survey 2017 to 2018

“…Based on existing literature and clinical relevance, body mass index (BMI), smoking, hypertension, and diabetes information were included as related covariates of GSD. [ 16 ] Consistent with similar literature, [ 17 ] sex, age, race, marital status, education, and poverty were incorporated as demographic covariates. Dietary energy intake was introduced as a covariate to reduce the recall bias of dietary intake.…”

The Role of Micronutrients in Human Papillomavirus Infection, Cervical Dysplasia, and Neoplasm

“…The impact of daily dietary intake was investigated by Barchitta et al, with the study showing a lower OR for infection with HR-HPVs (OR = 0.46; 95% CI = 0.27-0.80; p = 0.006) [39]. Data from 4628 women were obtained from the National Health and Nutrition Examination Survey (NHANES) [40]. The highest quartile of zinc intake showed an adjusted odds ratio for HR-HPVs infection of 0.72 (95% CI, 0.54-0.98) compared to the lowest quartile [40].…”

“…Data from 4628 women were obtained from the National Health and Nutrition Examination Survey (NHANES) [40]. The highest quartile of zinc intake showed an adjusted odds ratio for HR-HPVs infection of 0.72 (95% CI, 0.54-0.98) compared to the lowest quartile [40]. Recently, Ayatollahi et al performed a randomized controlled clinical trial among 40 patients with an HPV-positive test, ASCUS, or LSIL, to evaluate the effect of 220 mg of zinc every 12 h on the clearance of HPV infection.…”