Dietary zinc intake is inversely associated to metabolic syndrome in male but not in female urban adolescents

Suárez‐Ortegón, Milton Fabian; Ordoñez-Betancourth, Jenny E.; Plata, Cecilia Aguilar-de

doi:10.1002/ajhb.22408

Cited by 21 publications

(17 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These data seem to suggest that a dietary zinc intake within or slightly above the DRI could have a protective role on the risk of T2DM, but not when intake is very high. Consistent with our findings, several observational studies have shown a protective effect of a moderately high dietary zinc intake on cardiometabolic conditions, such as metabolic syndrome [44,45] and gestational hyperglycemia [46], and mortality by cardiovascular disease [47] and all causes [48]. Conversely, other studies have found no significant [10,49], or even direct associations [50,51] between dietary zinc intake and some of these cardiometabolic events.…”

Section: Discussionsupporting

confidence: 90%

Zinc Intake and Status and Risk of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

et al. 2019

View full text Add to dashboard Cite

Zinc could have a protective role against type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis aimed to evaluate the association between dietary, supplementary, and total zinc intake, as well as serum/plasma and whole blood zinc concentration, and risk of T2DM. Observational studies, conducted on cases of incident diabetes or T2DM patients and healthy subjects that reported a measure of association between zinc exposure and T2DM, were selected. Random effects meta-analyses were applied to obtain combined results. Stratified meta-analyses and meta-regressions were executed to assess sources of heterogeneity, as well as the impact of covariates on the findings. From 12,136 publications, 16 studies were selected. The odds ratio (OR) for T2DM comparing the highest versus lowest zinc intake from diet was 0.87 (95% CI: 0.78–0.98). Nevertheless, no association between supplementary or total zinc intake from both diet and supplementation, and T2DM was observed. A direct relationship was found between serum/plasma zinc levels and T2DM (OR = 1.64, 95% CI: 1.25–2.14). A moderately high dietary zinc intake, in relation to the Dietary Reference Intake, could reduce by 13% the risk of T2DM, and up to 41% in rural areas. Conversely, elevated serum/plasma zinc concentration was associated with an increased risk of T2DM by 64%, suggesting disturbances in zinc homeostasis.

show abstract

Section: Discussionsupporting

confidence: 90%

Zinc Intake and Status and Risk of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

et al. 2019

View full text Add to dashboard Cite

show abstract

“…An in vitro study reported that copper and flavonoids can form a metal ion complex. These metal chelating properties of flavonoids may play a role in metal-overload diseases and in all oxidative stress conditions involving a transition metal ion due to their anti-tumor properties [ 11 , 12 , 26 , 27 ]. However, we do not know whether these chelates of Cu and flavonoids can influence the effect of flavonoids on MetS in the human body.…”

Section: Discussionmentioning

confidence: 99%

Dietary Flavonoids, Copper Intake, and Risk of Metabolic Syndrome in Chinese Adults

Jia

Liu

et al. 2018

Nutrients

View full text Add to dashboard Cite

The effects of flavonoids and copper (Cu) on metabolic syndrome (MetS) have been investigated separately, but no information exists about the joint associations between flavonoids and Cu on the risk of MetS in population studies. In this cross-sectional study, a total of 9108 people aged 20–75 years from the Harbin Cohort Study on Diet, Nutrition, and Chronic Non-Communicable Diseases (HDNNCDS) were included. Flavonoid intakes were calculated based on the flavonoid database created in our laboratory. Cu and other nutrient intakes were estimated using the Chinese Food Composition Table. Among all study subjects, a total of 2635 subjects (28.9%) met the diagnostic criteria for inclusion in the MetS group. Total flavonoids (fourth vs. first quartile, odds ratio (OR): 0.77, 95% confidence interval (CI) 0.66–0.90, Ptrend = 0.002) and Cu (OR 0.81, 90% CI: 0.70–0.94, Ptrend = 0.020) were inversely associated with the risk of MetS after adjusting for potential confounders. Higher flavonoid intake was more strongly associated with a lower risk of MetS with high levels of Cu intake (Pinteraction = 0.008). Dose–response effects showed an L-shaped curve between the total intake of five flavonoids and the risk of MetS. These results suggest that higher flavonoid intake is associated with a lower risk of MetS, especially under high levels of Cu intake.

show abstract

“…The results of this study indicate the associations between low intake of Cu as well as high TC level and cardiometabolic risk, which are the risk factors in women. These data remain controversial because the study by Suarez-Ortegón et al [7] did not show an association between the consumption of Cu as well as lipid levels and metabolic syndrome in adolescents.…”

Section: Discussionmentioning

confidence: 94%

“…Previous studies have suggested that the intake of antioxidant nutrients, such as Zinc (Zn), Copper (Cu), Selenium (Se), and vitamins A, C, and E, protect against oxidative damage and its associated complications [7][8][9][10]. A meta-analysis showed that an increase of one portion per day in the consumption of fruits and vegetables is associated with a lower risk for mortality from CVD.…”

Section: Introductionmentioning

confidence: 99%

Association between the consumption of antioxidant nutrients with lipid alterations and cardiometabolic risk in adolescents

et al. 2018

View full text Add to dashboard Cite

Article based on the master thesis of LM NASCIMENTO, entitled "Prevalência de fatores de risco cardiovascular e sua associação com nutrientes em adolescentes". Universidade Federal do Piauí; 2017. Como citar este artigo/How A B S T R A C T ObjectiveThis study aimed at validating the associations between the consumption of antioxidant nutrients as well as lipid alterations and cardiometabolic risks in adolescents. MethodsThis cross-sectional study included 327 adolescents aged 14-19 years. Sociodemographic and dietary information, anthropometric and blood pressure measurements, and biochemical data were obtained. Cardiometabolic risk was calculated by aggregating the risk factors, which were expressed as the sum of Z-scores. Poisson regression was performed to estimate the prevalence ratios. ResultsIn boys, low intake of zinc was associated with elevated total cholesterol and triglyceride levels, whereas it was associated with low high-density lipoprotein cholesterol levels and high low-density lipoprotein cholesterol and total cholesterol levels in girls, thus indicating a cardiometabolic risk. Furthermore, low intake of copper was associated with high triglyceride levels and cardiometabolic risk in girls. The high prevalence ratios of high low-density lipoprotein cholesterol and total cholesterol levels and cardiometabolic risk were higher in those with low intake of vitamin A. Among girls, associations were also observed between lower intake of vitamin A and high triglyceride levels. Low intake of vitamin C among boys was associated with elevated high low-density lipoprotein cholesterol and triglyceride levels. Among girls, the intake of this vitamin was associated with lower low high-density lipoprotein cholesterol levels. In girls, low intake of vitamin E was associated with low low high-density lipoprotein cholesterol levels and high total cholesterol levels. ConclusionThe associations between antioxidant micronutrients as well as lipid alterations and cardiometabolic risk emphasize the importance of encouraging the consumption of foods that are rich in these nutrients to modulate lipid alterations and cardiometabolic risk.

show abstract

Dietary zinc intake is inversely associated to metabolic syndrome in male but not in female urban adolescents

Cited by 21 publications

References 32 publications

Zinc Intake and Status and Risk of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Zinc Intake and Status and Risk of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Dietary Flavonoids, Copper Intake, and Risk of Metabolic Syndrome in Chinese Adults

Association between the consumption of antioxidant nutrients with lipid alterations and cardiometabolic risk in adolescents

Contact Info

Product

Resources

About