Dietary α-Linked Galacto-Oligosaccharide Suppresses Ovalbumin-Induced Allergic Peritonitis in BALB/c Mice

Pirapatdit, Sooksan; Kishino, Eriko; Fujita, Katsuhide; Hashimoto, Hiroyuki; Mori, Shigeharu; Saito, Sanshiro; Sato, Toshiro; Watanabe, Jun; Sonoyama, Kei

doi:10.1271/bbb.80155

Cited by 9 publications

(8 citation statements)

References 31 publications

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“…Thus, prebiotics act first to ensure selective stimulation of the activity of beneficial autochtonous bacterial strains [38], but they do not stimulate the same genera of intestinal microbiota in humans and rodents. Indeed, in humans, prebiotics specifically increase bifidobacterial populations in fecal samples [33,44,45], whereas lactobacilli populations are increased significantly in the fecal microbiota of rodents (rat, mouse) [46,47]. Last but not least, some prebiotics (GOS) can exert a direct antimicrobial effect, as they can adhere to the binding sites of bacteria on the enterocyte surface and thus, block the adhesion of pathogenic bacteria to intestinal epithelial cells [42,48].…”

Section: Prebioticsmentioning

confidence: 99%

“…Animal models All animal studies have been performed in mice, particularly using those with a Balb/c genetic background [47,131,132]. Various prebiotics were used: GOS [47], FOS [132,133], or the GOS/inulin combination, with or without pectin-derived acidic oligosaccharides [131]. All studies showed a preventive effect of prebiotics on allergy.…”

Section: Effect Of Prebiotics On Allergymentioning

confidence: 99%

“…with OVA. Pirapatdit et al [47] showed that Balb/c mice, sensitized with OVA and receiving GOS-enriched feed, have fewer chemoattractant cytokines for cells involved in the allergic reaction. All of these studies were performed on adult mice (aged 4 -6 weeks when receiving the prebiotic), but it would be interesting to test the prebiotic effect during the perinatal period in the same way as probiotic strategies.…”

Section: Effect Of Prebiotics On Allergymentioning

confidence: 99%

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Probiotics, prebiotics, and synbiotics: impact on the gut immune system and allergic reactions

Gourbeyre

Denery

Bodinier

2011

Journal of Leukocyte Biology

333

196

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Probiotics and prebiotics, alone or together (synbiotics), can influence the intestinal microbiota and modulate the immune response. They may therefore be tools that can prevent or alleviate certain pathologies involving the gut immune system, such as allergies for which no treatment is yet available. This review focuses first on the definitions of probiotics, prebiotics, and synbiotics and key cells in the gut immune system. It then discusses their effects on mucosal immune stimulation. Experimental findings suggest that different probiotic species have similar effects on innate immunity by improving the mechanisms of pathogen destruction. On the contrary, their impacts seem to be variable on the adaptive immune system. Prebiotics can also exert an influence on the gut immune system via the stimulation of the autochthonous bacteria metabolism. Finally, this review focuses on the effects of food supplements on allergy. Different studies performed in humans or rodents have supported a potential role for selected probiotics and prebiotics in reducing some allergic parameters. Probiotic effects on allergy treatment are unclear, especially in human studies. However, they are potentially effective at short-term for prevention when they are administered in perinatal conditions. A clinical study performed with an infant cohort revealed a beneficial effect of prebiotics in preventing allergic manifestations at long-term. Further studies are nonetheless essential to confirm these findings. Food supplements offer potential tools for the prevention or treatment of allergy, but insufficient evidence is available at present to recommend their use in clinical practice.

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Section: Prebioticsmentioning

confidence: 99%

Section: Effect Of Prebiotics On Allergymentioning

confidence: 99%

Section: Effect Of Prebiotics On Allergymentioning

confidence: 99%

See 1 more Smart Citation

Probiotics, prebiotics, and synbiotics: impact on the gut immune system and allergic reactions

Gourbeyre

Denery

Bodinier

2011

Journal of Leukocyte Biology

333

196

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“…Recent studies suggested that some oligosaccharides modulate immune reactions directly [9,10,11,12]. Considering the utilization of LNB as a food material, such direct effect should be examined.…”

mentioning

confidence: 99%

Effect of Lacto-<i>N</i>-biose I on the Antigen-specific Immune Responses of Splenocytes

Goto

Takano-Ishikawa

Nishimoto

et al. 2012

Bioscience of Microbiota, Food and Health

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We examined the effect of lacto-N-biose I (LNB) on Antigen (Ag)-specific responses of immune cells. LNB exposure in vitro suppressed Ag-specific Interleukin (IL)-4 secretion of mouse splenocytes significantly. However, IL-4 secretion from CD4+ T cells stimulated with anti-CD3ε did not changed significantly with LNB exposure. Additionally, Ag-specific Th1 cytokines did not change. Therefore LNB might suppress Ag-specific IL-4 through modification of Ag-presenting cells (APCs) in a manner independent of Th1-type immune development.

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“…Otro de los efectos bioactivos que se les atribuye a los oligosacáridos es la capacidad de modular directamente la respuesta inmune (Osanya et al, 2011;Pirapatdit et al, 2008;Sonoyama et al, 2005), así se han descrito efectos inmunomoduladores para OLH sialilados (Bode et al, 2004a;Bode et al, 2004b;Eiwegger et al, 2010;Eiwegger et al, 2004) y fucosilados (Atochina and Harn, 2005;Terrazas et al, 2001).…”

Section: Producción De Lnb Y Gnb Y Evaluación De Su Potencial Prebióunclassified

Metabolismo y síntesis de oligosacáridos de la leche humana mediante la utilización de enzimas glicosil hidrolasas de Lactobacillus casei

Costoya¹

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where I spent three months carrying out the immunomodulatory experiments described in the chapter 4. To Linette Willemsen, thanks for patiently explaining me, a thousand times, everything that I did not understood regarding immunology and immunomodulation. Thanks for showing me your particular philosophical approach to science, and for showing that we are fortunate to do what we love and to contribute from our position. To Gemma Dingjan, thank you for helping me with all the experiments, for working side by side with me even during weekends and specially for helping me make my stay in Utrecht and in the laboratory not only fruitful, but also funy, introducing me to the people and integrating me into the out work activities.

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Dietary α-Linked Galacto-Oligosaccharide Suppresses Ovalbumin-Induced Allergic Peritonitis in BALB/c Mice

Cited by 9 publications

References 31 publications

Probiotics, prebiotics, and synbiotics: impact on the gut immune system and allergic reactions

Probiotics, prebiotics, and synbiotics: impact on the gut immune system and allergic reactions

Effect of Lacto-<i>N</i>-biose I on the Antigen-specific Immune Responses of Splenocytes

Metabolismo y síntesis de oligosacáridos de la leche humana mediante la utilización de enzimas glicosil hidrolasas de Lactobacillus casei

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