Effect of Lacto-&lt;i&gt;N&lt;/i&gt;-biose I on the Antigen-specific Immune Responses of Splenocytes

Goto, Masao; Takano-Ishikawa, Yuko; Nishimoto, Mamoru; Kitaoka, Motomitsu

doi:10.12938/bmfh.31.47

Cited by 2 publications

(2 citation statements)

References 24 publications

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“…on the previous research, the LNB immunomodulatory behavior employing mice's naive immune cell expressing Receptor T-cells (TCR) especially chicken ovalbumin (OVA) demonstrated that the LNB exposure greatly decreased the Ag-specific production of IL-4 [33]. IL-4 is the leading development of the ag-specific Th2 cell in association with cytokine.…”

Section: Basedmentioning

confidence: 95%

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Potential of lacto-N-biose I as a prebiotic for infant health: A review

Kiyat

Astuti

Budijanto

et al. 2021

CST

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Prebiotic is one alternative in the prevention of disease in infants. Generally, it is available as oligosaccharide which may occur naturally, but can also be added as a dietary supplement for food, beverage or formula. Lacto-N-biose I (LNB), a kind of prebiotic has not been widely examined in regard to its activities as a bifidogenic factor. Naturally, it is available in a compound form in human milk oligosaccharide (HMO) as the main constituent of human milk rather than fat and protein. HMOs also have prebiotic activity in the body and play an important role in providing nutrition for the infant health. LNB is potential to be used in food ingredient, especially infant food formula regarding the prebiotic effect and it could be enzymatically synthesized using enzymes involved in the LNB biosynthesis pathway by microorganisms.

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Section: Basedmentioning

confidence: 95%

“…It changes the effect of Gal-3, which binds LNB to damage the function partially and only reduce the secretion of Ag-specific IL-4. In general, by the modification of APCs signal, LNB affects Ag-specific immune response [33].…”

Section: Basedmentioning

confidence: 99%

Potential of lacto-N-biose I as a prebiotic for infant health: A review

Kiyat

Astuti

Budijanto

et al. 2021

CST

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Large scale production of lacto-N-biose I, a building block of type I human milk oligosaccharides, using sugar phosphorylases

Nishimoto

2020

Bioscience, Biotechnology, and Biochemistry

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Human milk oligosaccharides (HMOs) have drawn attention for their contribution to the explosive bifidobacterial growth in the intestines of neonates. We found that bifidobacteria can efficiently metabolize lacto-N-biose I (LNB), the major building blocks of HMOs, and we have developed a method to synthesize LNB by applying this system. We produced LNB on a kilogram scale by the method. This proved that, among the enterobacteria, only bifidobacteria can assimilate LNB, and provided the data that supported the explosive growth of bifidobacteria in neonates. Furthermore, we were also able to reveal the structure of LNB crystal and the low stability for heating at neutral pH, which has not been clarified so far. In this paper, using bifidobacteria and LNB as examples, I describe the research on oligosaccharide synthesis that was conducted by utilizing a sugar metabolism. Abbreviations: LNB: lacto-N-biose I; GNB: galacto-N-biose; HMOs: human milk oligosaccharides; GLNBP: GNB/LNB phosphorylase; NahK: N-acetylhexosamine 1-kinase; GalT: UDP-glucose-hexose-1-phosphate uridylyltransferase; GalE: UDP-glucose 4-epimerase; SP: sucrose phosphorylase.

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Effect of Lacto-<i>N</i>-biose I on the Antigen-specific Immune Responses of Splenocytes

Cited by 2 publications

References 24 publications

Potential of lacto-N-biose I as a prebiotic for infant health: A review

Potential of lacto-N-biose I as a prebiotic for infant health: A review

Large scale production of lacto-N-biose I, a building block of type I human milk oligosaccharides, using sugar phosphorylases

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