Dietary α-linolenic acid, linoleic acid, and n–3 long-chain PUFA and risk of ischemic heart disease

Abstract

This study suggests that there is no association between ALA intake and risk of IHD, but a high intake of n-3 LC-PUFA had a significant cardioprotective effect in women.

Dietary Linoleic Acid and Risk of Coronary Heart Disease: A Systematic Review and Meta-Analysis of Prospective Cohort Studies

“…After screening the titles and abstracts, 566 full-text articles were evaluated which 6 original articles were identified as being appropriate for inclusion in this meta-analysis. 24–29 We also obtained permission from principal investigators of the cohort studies presented in the Pooling Project of Cohort Studies on Diet and Coronary Disease, 4 to examine the association between LA intake and CHD risk and included these results in the meta-analysis. The characteristics of these cohort studies in the pooling project were described elsewhere in detail.…”

“…In addition, we included the results of three other previously published studies. 24,25,29 In the NHS and HPFS, we updated the published analyses with longer follow-up: from 20 years in previous publications to 30 years in the NHS, and from 6 years to 24 years in the HPFS. In addition, we reanalyzed data in ATBC study to adjust for the confounding variables similar to other included cohort studies in this meta-analysis (Table 1).…”

Metabolism and functional effects of plant-derived omega-3 fatty acids in humans

“…In older epidemiological studies, Oomen et al and Simon et al found no association between ALA intake and CHD risk [216,217]. More recently, Vedtofte et al suggested that there is no association between ALA intake and risk of ischemic heart disease [218] and Lemtaire et al concluded that ALA is not associated with incident congestive heart failure (CHF) in older adults [219], which is in agreement with findings from another prospective study by Gode et al reporting no association between ALA intake and incident CHD [220].…”

Physicochemical characterization of chia (<i>Salvia hispanica</i>) seed oil from Yucatán, México

“…Besides, the additive effect of α-linolenic acid (ALA) and n-3 long-chain PUFA was observed to exhibit cardio-protective effects in women [11], which led to consequent human clinical studies of chia on disease risk factors. To date, four clinical trials have been carried out.…”