Dietary ω-3 fatty acid and ω-3: ω-6 fatty acid ratio predict improvement in glucose disturbances in Japanese Brazilians

Sartorelli, Daniela Saes; Damião, Renata; Chaim, Rita; Hirai, Amélia; Gimeno, Suely G A; Ferreira, Sandra Roberta Gouvêa

doi:10.1016/j.nut.2009.03.013

Cited by 12 publications

(5 citation statements)

References 36 publications

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“…Long chain n-3 PUFA intervention studies have shown benefits on several key metabolic risk factors, e.g. lowers the blood pressure and triglycerides [20], reduce inflammatory markers [21], and improve glucose metabolism [22] and insulin sensitivity [23]. …”

Section: Introductionmentioning

confidence: 99%

Effects of supplementation with n-3 polyunsaturated fatty acids on cognitive performance and cardiometabolic risk markers in healthy 51 to 72 years old subjects: a randomized controlled cross-over study

Nilsson

Radeborg

Salo

et al. 2012

Nutr J

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BackgroundHigher plasma n-3 polyunsaturated fatty acids (PUFA) have been associated with a lower risk of age related cognitive decline, and to beneficially affect cardiometabolic risk factors. A relation exists between metabolic disorders such as diabetes type 2 and cognitive decline. Results regarding the potential effects of n-3 PUFA on risk factors in healthy subjects are divergent, and studies regarding the possible relation between cardiometabolic parameters and cognitive performance are scarce. The objective was to evaluate the effects of five weeks intake of long chain n-3 PUFA on cognitive performance in healthy individuals, and to exploit the possible relation between outcomes in cognitive tests to cardiometabolic risk parameters.MethodsFish oil n-3 PUFA (3g daily) were consumed during 5weeks separated by a 5 week washout period in a cross-over placebo controlled study, including 40 healthy middle aged to elderly subjects. Cognitive performance was determined by tests measuring working memory (WM) and selective attention.ResultsSupplementation with n-3 PUFA resulted in better performance in the WM-test compared with placebo (p < 0.05). In contrast to placebo, n-3 PUFA lowered plasma triacylglycerides (P < 0.05) and systolic blood pressure (p < 0.0001). Systolic blood pressure (p < 0.05), f-glucose (p = 0.05), and s-TNF-α (p = 0.05), were inversely related to the performance in cognitive tests.ConclusionsIntake of n-3 PUFA improved cognitive performance in healthy subjects after five weeks compared with placebo. In addition, inverse relations were obtained between cardiometabolic risk factors and cognitive performance, indicating a potential of dietary prevention strategies to delay onset of metabolic disorders and associated cognitive decline.

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Section: Introductionmentioning

confidence: 99%

Effects of supplementation with n-3 polyunsaturated fatty acids on cognitive performance and cardiometabolic risk markers in healthy 51 to 72 years old subjects: a randomized controlled cross-over study

Nilsson

Radeborg

Salo

et al. 2012

Nutr J

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“…Thus adherence to MedD is probably associated with a reduced cardiometabolic risk and this protection is not specific to the French population [46,47] which is only partially exposed to the MedD pattern. One of numerous characteristics of the MedD pattern is a low n-6/n-3FAR.…”

Section: Discussionmentioning

confidence: 97%

From French to Mediterranean Diet: Importance of the Omega-6/Omega-3 Fatty Acids Ratio

Elisha¹,

Guebre-Egziabher²,

Vidal³

et al. 2011

World Review of Nutrition and Dietetics

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“…Mirmiran et al (2012) showed that the dietary intake of LA decreased the risk for the metabolic syndrome, while ALA intake was inversely associated with the metabolic syndrome in Tehranian adults. Also, a higher dietary intake of ω-3 PUFA improves the glucose metabolism in high-risk individuals (Sartorelli et al, 2010), but in the same time increases the symptoms of coronary disease (Subash-Babu and Alshatwi, 2018). These ω-6 and ω-3 PUFA are the precursors for the synthesis of long-chain PUFA eicosapentaenoic and docosahexaenoic acids, implicated in control of lipid accumulation and coronary heart disease (Subash-Babu and Alshatwi, 2018), while ω-6 can be converted into arachidonic acid (Park et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Nutritional Potential of Some Cold Pressed Vegetable Oils in Terms of Fatty Acids

Mihai¹,

Negoiţă²,

Horneț³

2020

CTNS

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The objective of this study was to evaluate the nutritional potential of some unrefined vegetable oils in terms of fatty acid composition which was determined by gas chromatography coupled with mass spectrometry. Eight types of vegetable oils, obtained by cold pressing of raw plant materials of sunflower, rapeseed, soybean, flaxseed, sesame, pumpkin, hempseed and walnut were used in the experiments. For all samples, the fatty acid composition was determined individually or as sum of saturated (SFA), monounsaturated (MUFA) and polyunsaturated (PUFA) fatty acids, and omega-6 (ω-6) and omega-3 (ω-3) were also evaluated. Compared with the other tested oils, walnut oil was characterized by the lowest concentrations in SFA (5.33%) and MUFA (15.97%) and the highest concentrations in PUFA (78.70%). Soybean oil had the highest content in SFA (18.70%), while the rapeseed oil was characterized by the highest content in MUFA (67.49%) and the lowest content in PUFA (24.74%). Nutritional claims regarding the MUFA content can be made for rapeseed oil, while for the other tested oils can be mentioned that are high in PUFA. The soybean, rapeseed, flaxseed, hempseed and walnut cold pressed oils can be considered to have nutritional potential due to the high amounts of ω-3 PUFA.

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Dietary ω-3 fatty acid and ω-3: ω-6 fatty acid ratio predict improvement in glucose disturbances in Japanese Brazilians

Abstract: Our findings support the evidence of an independent protective effect of omega-3 fatty acid and of a higher omega-3:omega-6 fatty acid ratio on the glucose metabolism of high-risk individuals.

Cited by 12 publications

References 36 publications

Effects of supplementation with n-3 polyunsaturated fatty acids on cognitive performance and cardiometabolic risk markers in healthy 51 to 72 years old subjects: a randomized controlled cross-over study

Effects of supplementation with n-3 polyunsaturated fatty acids on cognitive performance and cardiometabolic risk markers in healthy 51 to 72 years old subjects: a randomized controlled cross-over study

From French to Mediterranean Diet: Importance of the Omega-6/Omega-3 Fatty Acids Ratio

Nutritional Potential of Some Cold Pressed Vegetable Oils in Terms of Fatty Acids

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