2009
DOI: 10.1016/j.toxlet.2009.09.016
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Diethylnitrosamine (DEN) induces irreversible hepatocellular carcinogenesis through overexpression of G1/S-phase regulatory proteins in rat

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Cited by 88 publications
(59 citation statements)
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“…DEN is an extensively studied liver carcinogen as a promoting agent of preneoplastic changes (22). Our data confirm this concept because all the animals that received DEN presented preneoplastic foci, while in the control group, no hepatocyte damage was observed.…”
Section: Discussionsupporting
confidence: 86%
“…DEN is an extensively studied liver carcinogen as a promoting agent of preneoplastic changes (22). Our data confirm this concept because all the animals that received DEN presented preneoplastic foci, while in the control group, no hepatocyte damage was observed.…”
Section: Discussionsupporting
confidence: 86%
“…Using Statistical Package for the Social Sciences (SPSS) 16.0 (SPSS, USA), one-way ANOVA compared the absolute values of spectral variables among the three groups of samples. A probability (p) value of p<0.05 was considered statistically significant.…”
Section: Discussionmentioning
confidence: 99%
“…Diethylnitrosamine (DEN)-induced HCC rats are a good animal model for HCC investigation and have been used extensively in experimental studies [15,16]. DEN is a Nnitroso compound, mainly metabolized in the liver by cytochrome P450 enzymes to form reactive electrophiles such as reactive oxygen species.…”
Section: Introductionmentioning
confidence: 99%
“…The activity of GL63 was also evaluated in the present study using male Wistar rats, which is an animal model for studies of human hepatocarcinoma (49). For these in vivo studies, rats were divided into six different groups according to the requirements of the experimental design, and the animals were injected DEN into the peritoneum to induce hepatocarcinoma.…”
Section: E F C B Amentioning
confidence: 99%