Diethylstilbestrol (DES)-induced clear cell adenocarcinoma of the vagina metastasizing to the brain

Lin, Li; Sciubba, Daniel M.; Gallia, Gary L.; Sosnowski, Jeffrey; Weingart, Jon

doi:10.1016/j.ygyno.2007.01.014

Cited by 11 publications

(5 citation statements)

References 14 publications

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“…Then the miRNAs ( miR-15b-5p and miR-16-5p ) that the lncRNA AC018647.3 competed with KDR and CITED2 in primary of LUSC were identified. Finally, five drugs (17beta-estradiol (E2), Diethylstilbestrol, Etoposide, 5-Fluorouracil, Dexamethasone) that inhibited the upregulation of these two miRNAs were identified, and Diethylstilbestrol, Etoposide, 5-Fluorouracil and Dexamethasone among them were confirmed their potential association with lung cancer based on some studies ( 45 – 48 ). Therefore, we believe that 17beta-estradiol (E2) may also have some potential efficacy on primary LUSC.…”

Section: Resultsmentioning

confidence: 92%

Identification of Primary and Metastatic Lung Cancer-Related lncRNAs and Potential Targeted Drugs Based on ceRNA Network

Dong

Song

et al. 2021

Front. Oncol.

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Lung cancer metastasis is the leading cause of poor prognosis and death for patients. Long noncoding RNAs (lncRNAs) have been validated the close correlation with lung cancer metastasis, but few comprehensive analyses have reported the specific association between lncRNA and cancer metastasis, especially via both competing endogenous RNA (ceRNA) regulatory relationships and functional regulatory networks. Here, we constructed primary and metastatic ceRNA networks, identified 12 and 3 candidate lncRNAs for lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) respectively and excavated some drugs that might have potential therapeutic effects on lung cancer progression. In summary, this study systematically analyzed the competitive relationships and regulatory mechanism of the repeatedly dysregulated lncRNAs in lung cancer carcinogenesis and metastasis, and provided a new idea for screening potential therapeutic drugs for lung cancer.

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Section: Resultsmentioning

confidence: 92%

Identification of Primary and Metastatic Lung Cancer-Related lncRNAs and Potential Targeted Drugs Based on ceRNA Network

Dong

Song

et al. 2021

Front. Oncol.

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“…7 with rare occurrences in vagina (5-10%). 8 In vagina, their most common location is anterior vaginal wall, 9 but it can also occur elsewhere.…”

Section: Discussionmentioning

confidence: 99%

“…4 PVCC usually presents as abnormal vaginal bleeding or discharge 4 although 16 -25% are asymptomatic. 9 Zong et al documented that clinical presentation is often atypical in PVCC patients with a congenital malformation. Intermenstrual vaginal bleeding was the most common presenting symptom (54.8%) in their study.…”

Section: Discussionmentioning

confidence: 99%

“…Depending upon the stage and grade of disease, most patients are treated with combination of radical surgery and radiation therapy. 9 Chemotherapy is infrequently used because of associated poor outcomes. 5 year survival in stage I PVCC is only 56 %.…”

Section: Discussionmentioning

confidence: 99%

“…Recurrence has been observed as long as 20 years after primary therapy emphasizing the importance of prolonged follow-up. 9 CCAs are prone for widespread dissemination with the lungs, supraclavicular lymph nodes and pelvis being the most common sites of tumour metastasis. 9 Cerebral 9 and cardiac metastasis 15 has also been reported.…”

Section: Discussionmentioning

confidence: 99%

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Primary clear cell adenocarcinoma of the vagina in a young female with uterus didelphys

Singh¹,

Tewari²,

Satyam³

et al. 2020

ACHR

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Adenocarcinomas of clear cell type are uncommon tumors accounting for 5-10% of all vaginal tumours which in turn account for approximately 2% of all gynaecologic malignancies. Though Clear cell Adenocarcinomas arising in the setting of previous Di-Ethyl-Stilbesterol [DES] exposure have been reported quite often, only few cases of these not associated with DES have been documented. Amongst non-DES exposed patients, CCAs are said to be sporadic or in association with endometriosis in women of peri/postmenopausal age or in association with some congenital genitourinary anomalies mostly affecting young females. Case Report: A 16 year old female presented with heavy bleeding per vaginum since 2 months. On per vaginal examination a polypoidal mass was felt on posterior wall of vagina. Ultrasonography revealed the presence of a uterus didelphys in addition to this mass. Polypectomy was done. On microscopy, a diagnosis of clear cell adenocarcinoma was made which was confirmed on immunohistochemistry. There was no history of any DES exposure in the mother. Conclusion:We present here a case of an adolescent female with uterus didelphys and no DES exposure who was diagnosed as a case of Vaginal Clear cell Adenocarcinoma. The rarity of this tumour among DESexposed cases and its presence in non-exposed patients warrants a more thorough search for the underlying pathology.

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Risques de cancer après exposition au DES

Agostini

Blanc

Lazard

et al.

Le Distilbène® Trente Ans Après

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Diethylstilbestrol (DES)-induced clear cell adenocarcinoma of the vagina metastasizing to the brain

Cited by 11 publications

References 14 publications

Identification of Primary and Metastatic Lung Cancer-Related lncRNAs and Potential Targeted Drugs Based on ceRNA Network

Identification of Primary and Metastatic Lung Cancer-Related lncRNAs and Potential Targeted Drugs Based on ceRNA Network

Primary clear cell adenocarcinoma of the vagina in a young female with uterus didelphys

Risques de cancer après exposition au DES

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