Dif, a dorsal-related gene that mediates an immune response in Drosophila

Yt, Ip; Reach, Michael; Engström, Ylva; Kadalayil, Latha; Cai, Hao; González-Crespo, Sergio; Tatei, Kazuaki; Levine, Michael

doi:10.1016/0092-8674(93)90495-c

Cited by 422 publications

(297 citation statements)

References 64 publications

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“…5, the identity of the transactivator bound to the cactus protein, and presumably released upon immune challenge, is indicated as Re1 X. Three Re1 proteins are at present known from Drosophila: d~r s a l @~,~~) , Dif (for dorsalrelated immune factor) (78) and Relish (an analogue of mammalian pl05, the precursor of ~5 0 ) (~~) .…”

Section: The Expression Of the Genes Encoding Antimicrobial Peptidesmentioning

confidence: 99%

Antimicrobial peptide defense in Drosophila

1997

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Drosophila responds to a septic injury by the rapid synthesis of antimicrobial peptides. These molecules are predominantly produced by the fat body, a functional equivalent of mammalian liver, and are secreted into the hemolymph where their concentrations can reach up to 100 μM. Six distinct antibacterial peptides (plus isoforms) and one antifungal peptide have been characterized in Drosophila and their genes cloned. The induction of the gene encoding the antifungal peptide relies on the spätzle/Toll/cactus gene cassette, which is involved in the control of dorsoventral patterning in the embryo, and shows interesting structural and functional similarities with cytokine‐induced activation of NF‐ϰB in mammalian cells. An additional pathway, dependent on the as yet unidentified imd (for immune‐deficiency) gene, is required for the full induction of the antibacterial peptide genes. Mutants deficient for the Toll and imd pathways exhibit a severely reduced survival to fungal and bacterial infections, respectively. Recent data on the molecular mechanisms underlying recognition of non‐self are also discussed in this review.

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Section: The Expression Of the Genes Encoding Antimicrobial Peptidesmentioning

confidence: 99%

Antimicrobial peptide defense in Drosophila

1997

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“…More generally, the interaction between nuclear factors from distinct families plays a major role in the expression of many genes ofthe acute phase response, as is illustrated by the synergism between NF-1L6 and NF-icB in the transcription of IL6 and 1L8 genes (9). There are many provocative similarities between the insect host defense and the mammalian acute phase response and we and others have recently argued that these responses might be homologous, deriving from a common ancestral defense mechanism (1,2,10).…”

Section: Introductionmentioning

confidence: 99%

Drosophilaimmunity. A sequence homologous to mammalian interferon consensus response element enhances the activity of the diptericin promoter

et al. 1995

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“…The systemic response to bacterial and fungal infection in Drosophila is mediated by two major signaling pathways that lead to the production of anti-microbial factors: the Toll pathway, which primarily responds to Gram-positive and fungal pathogens and the Immune deficiency (IMD) pathway, which largely responds to Gram-negative bacteria [6,7,15]. Another pathway that has known signaling roles in innate immunity and in particular in anti-viral immunity is the JAK/Stat pathway [16][17][18].…”

Section: Anti-microbial Signaling Screensmentioning

confidence: 99%

Genomic RNAi screening in Drosophila S2 cells: what have we learned about host–pathogen interactions?

Cherry

2008

Current Opinion in Microbiology

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The détente between pathogen and host has been of keen interest to researchers in spite of being exceedingly difficult to probe. Recently, new RNA interference (RNAi) technologies, in particular in Drosophila tissue culture cells, have made it possible to interrogate the genetics of host organisms rapidly, with nearly complete genomic coverage and high fidelity. Therefore, it is not surprising that the applications of RNAi to the study of host-pathogen interactions were amongst the first to be published, and have already revealed many new insights into the hosts' role in infection. This review will highlight the application of RNAi screening to pathogen-host interactions in Drosophila cells and will reveal some of the lessons learned from this approach.

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Dif, a dorsal-related gene that mediates an immune response in Drosophila

Cited by 422 publications

References 64 publications

Antimicrobial peptide defense in Drosophila

Antimicrobial peptide defense in Drosophila

Drosophilaimmunity. A sequence homologous to mammalian interferon consensus response element enhances the activity of the diptericin promoter

Genomic RNAi screening in Drosophila S2 cells: what have we learned about host–pathogen interactions?

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