Difference between electrical remodelling after pulmonary veins and right atrium appendage pacing

Abstract

Our findings provide likely ionic mechanisms of shortened repolarization in induced atrial tachycardia with a decrease in I(Ca,L) and I(to) densities, which is the likely mechanism for a decrease in action potential duration rate adaptation in the canine rapid pacing model more pronounced in the PVs pacing group underlying the crucial role of PVs in initiating AF.

Atrial Structure and Function and its Implications for Current and Emerging Treatments for Atrial Fibrillation

“…These intrinsic anatomical and structural features promote rapid electrical and structural remodelling even in the settings of considerably modest AF burdens (such as 'lone' AF). [43][44][45] Myocardial fibres along the intervenous ridges may be associated with epicardial connections facilitating PV-LA connections across an apparent circumferential line of block. 46 In addition, the left lateral ridge [also known as the LA appendage (LAA/PV ridge)] which divides the anterior region of the left PVs and the LAA, has been well described as a highly arrhythmogenic region.…”