Difference in the binocular rivalry rate between depressive episodes and remission

Jia, Ting; Ye, Xing; Wei, Qiang; Xie, Wen; Cai, Chunlan; Mu, Jingjing; Dong, Yi; Hu, Panpan; Hu, Xinglong; Tian, Yanghua; Wang, Kai

doi:10.1016/j.physbeh.2015.08.007

Cited by 23 publications

(41 citation statements)

References 49 publications

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“…It has been shown that in a neurotypical population there is a link between glutamate and GABA levels and rivalry rate, [25] and that higher GABA concentration in the visual cortex leads to a lower rivalry rates. [26] These findings imply that a glutamate and/or a GABA dysregulation in the visual cortex would lead to an abnormal rivalry dynamics; this proposition is supported by research showing lower rivalry rate in neurological disorders associated with GABAergic transmission abnormalities such as bipolar disorder, [27,28] schizophrenia, [29] major depression, [30] attention deficit and hyperactivity disorder, [31] and autism spectrum disorder. [25,32] Glutamate excitotoxicity has been implicated in neurodegenerative diseases such as multiple sclerosis, [33] Alzheimer's disease, and Huntington's disease, [34] but binocular rivalry has not been studied in patients affected by these conditions.…”

Section: Discussionmentioning

confidence: 83%

Intra- and inter-hemispheric processing during binocular rivalry in mild glaucoma

et al. 2020

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Glaucoma is considered a progressive optic neuropathy because of the damage and death of the retinal ganglion cells. It is also a neurodegenerative disease because it affects neural structures in the visual system and beyond, including the corpus callosum-the largest white matter structure involved in inter-hemispheric transfer of information. In this study we probed the dysfunction of the inter-hemispheric processing in patients with mild glaucoma using the phenomenon of binocular rivalry. Patients with mild glaucoma and no measurable visual field defects and age-matched controls underwent a thorough visual assessment. Then they participated in a series of psychophysical tests designed to examine the binocular rivalry derived from intra-and inter-hemispheric processing. Static horizontal and vertical sinewave gratings were presented dichoptically using a double-mirror stereoscope in 3 locations: centrally, to probe inter-hemispheric processing, and peripherally to the left or to the right, to probe intra-hemispheric processing. Although the two groups were matched in functional measures, rivalry rate of the glaucoma group was significantly lower than that of the control group for the central location, but not for the peripheral location. These results were driven mainly by the patients with normal tension glaucoma whose average rivalry rate for the central location (from which information reaches the two hemispheres) was almost half (46% lower) that of the controls. These results indicate a dysfunction in inter-hemispheric transfer in mild glaucoma that can be detected behaviourally before any changes in standard functional measures.

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Section: Discussionmentioning

confidence: 83%

Intra- and inter-hemispheric processing during binocular rivalry in mild glaucoma

et al. 2020

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“…Binocular rivalry has been widely investigated in the fields of cognitive and visual science and is linked to the superior parietal lobe. In recent years, an increasing number of studies have begun to explore the phenomenon of binocular rivalry in the context of psychiatric diseases (Miller et al, 2003 ; Jia et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

“…Studies have shown that TMS application in the anterior parietal lobe causes binocular rivalry and bistable perception alternations to accelerate (Baker et al, 2015 ). However, the rate of bistable perception is reduced in patients with mental disorders, including BD and depression (Miller et al, 2003 ; Jia et al, 2015 ), compared to healthy controls. Study has demonstrated that binocular rivalry is slower in first-degree relatives of SZ (Wright et al, 2003 ).…”

Section: Introductionmentioning

confidence: 99%

Slow Binocular Rivalry as a Potential Endophenotype of Schizophrenia

Xiao

Chen

et al. 2018

Front. Neurosci.

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Objectives: Binocular rivalry is a typical example of bistable perception that arises when two monocular images are simultaneously presented to each eye. Binocular rivalry is a heritable perceptual cognitive function that is impaired in patients with schizophrenia (SZ). Despite its potential suitability as a visual endophenotype, binocular rivalry has hardly been studied in the unaffected siblings of schizophrenia (SIB). There is also little research about whether binocular rivalry is a potential visual endophenotype between SZ and SIB.Methods: In our cross-sectional study, we included 40 SZ and their unaffected SIBs, as well as 40 age- and sex-matched healthy controls (HC). All subjects underwent the binocular rivalry test, the Positive and Negative Syndrome Scale (PANSS) and a battery of cognitive neuropsychological assessments evaluating attention, memory and executive function domains.Results: Our results demonstrate that the switching rate in SZ was significantly slower than in HC (p < 0.001), and compared to the SIB, the mean alternation rates were significantly different (p < 0.01). Moreover, there was a significant difference in mean switching rate between the SIB and the HC (p < 0.001). There was no significant correlation between the alternation rate of binocular rivalry and these cognitive tasks and the PANSS scores.Conclusion: The present study shows that SZ and SIB both exhibit changes in binocular rivalry, with SIB exhibiting intermediate performance compared with that of SZ and the HC. This supports the claim that the switching rate for SZ differs from that of SIB and suggests that binocular rivalry may qualify as a visual endophenotype for SZ.

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“…Following Pettigrew and Miller's [68] original study on BD, other clinical psychiatric conditions have been examined including schizophrenia and major depression [39,53], autism spectrum conditions [4,26,42,[71][72][73], attention deficit hyperactivity disorder (e.g., [3,6]), and generalized social anxiety disorder [5]. Although some researchers (e.g., [82]) have attempted to use the same testing protocol as that of Pettigrew and Miller [68], so that data may be directly compared between clinical studies, other researchers have employed different test protocols (e.g., shorter viewing durations, different stimulus characteristics, different response options), making comparisons difficult.…”

Section: Introductionmentioning

confidence: 99%

The effect of stimulus strength on binocular rivalry rate in healthy individuals: Implications for genetic, clinical and individual differences studies

Law

Miller

Ngo

2017

Physiology & Behavior

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Binocular rivalry (BR) occurs when conflicting images concurrently presented to corresponding retinal locations of each eye stochastically alternate in perception. Anomalies of BR rate have been examined in a range of clinical psychiatric conditions. In particular, slow BR rate has been proposed as an endophenotype for bipolar disorder (BD) to improve power in large-scale genome-wide association studies. Examining the validity of BR rate as a BD endophenotype however requires large-scale datasets (n=1000s to 10,000s), a standardized testing protocol, and optimization of stimulus parameters to maximize separation between BD and healthy groups. Such requirements are indeed relevant to all clinical psychiatric BR studies. Here we address the issue of stimulus optimization by examining the effect of stimulus parameter variation on BR rate and mixed-percept duration (MPD) in healthy individuals. We aimed to identify the stimulus parameters that induced the fastest BR rates with the least MPD. Employing a repeated-measures within-subjects design, 40 healthy adults completed four BR tasks using orthogonally drifting grating stimuli that varied in drift speed and aperture size. Pairwise comparisons were performed to determine modulation of BR rate and MPD by these stimulus parameters, and individual variation of such modulation was also assessed. From amongst the stimulus parameters examined, we found that 8cycles/s drift speed in a 1.5° aperture induced the fastest BR rate without increasing MPD, but that BR rate with this stimulus configuration was not substantially different to BR rate with stimulus parameters we have used in previous studies (i.e., 4cycles/s drift speed in a 1.5° aperture). In addition to contributing to stimulus optimization issues, the findings have implications for Levelt's Proposition IV of binocular rivalry dynamics and individual differences in such dynamics.

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Difference in the binocular rivalry rate between depressive episodes and remission

Cited by 23 publications

References 49 publications

Intra- and inter-hemispheric processing during binocular rivalry in mild glaucoma

Intra- and inter-hemispheric processing during binocular rivalry in mild glaucoma

Slow Binocular Rivalry as a Potential Endophenotype of Schizophrenia

The effect of stimulus strength on binocular rivalry rate in healthy individuals: Implications for genetic, clinical and individual differences studies

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