Difference of the hippocampal and white matter microalterations in MCI patients according to the severity of subcortical vascular changes: Neuropsychological correlates of diffusion tensor imaging

Shim, Yong S.; Yoon, Bora; Shon, Young-Min; Ahn, Kook Jin; Yang, Dong-Won

doi:10.1016/j.clineuro.2008.02.021

Cited by 40 publications

(39 citation statements)

References 56 publications

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“…In men, the risk of decline in executive dysfunction was associated with a hypercholesterolemic pattern. This specific effect on frontal executive functions could be related to microalterations in white matter lesions and other subcortical vascular changes and could be amongst the earliest signs of vascular mild cognitive impairment which are more likely to evolve towards either vascular or mixed vascular and Alzheimer's dementia (Howieson et al, 2008;Iachini et al, 2009;Shim et al, 2008). This is partly compatible with our recent finding that in men specifically, low HDL-C levels was a risk factor for all-cause dementia including vascular dementia but not Alzheimer's disease .…”

Section: Discussionsupporting

confidence: 86%

Gender-specific associations between lipids and cognitive decline in the elderly

Ancelin

Ripoche

Dupuy

et al. 2014

European Neuropsychopharmacology

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The aim of this study was to examine the associations between serum lipid levels and cognitive function in a community-based sample of non-demented subjects aged 65 years and over.Participants were 2737 men and 4118 women from a population-based cohort recruited from three French cities. Visual memory, verbal fluency, psychomotor speed, and executive abilities were evaluated at baseline, and after 2, 4, and 7 years of follow-up. Lipid levels were evaluated at baseline. Multiadjusted Cox models stratified by gender were adjusted for sociodemographic and lifestyle characteristics, mental and physical health, and genetic vulnerability to dyslipidemia (apolipoprotein E and A, and cholesteryl ester transfer protein) and taking into account baseline vascular pathologies. In men, a hypercholesterolemic pattern in late-life (high total cholesterol (T-C), low HDL-C, high LDL-C levels) was associated with a 25 to 50% increased risk of decline over 7 years in psychomotor speed, executive abilities, and verbal fluency. Specific associations with low T-C and low LDL-C levels were also observed which may depend on genetic vulnerability to dyslipidemia (related to apolipoprotein A5 and cholesteryl exchange transfer protein). In contrast, in women, a 30% higher rate of decline was found in psychomotor speed with high HDL-C levels and in executive abilities with low levels of LDL-C and triglycerides, in interaction with hormonal treatment. For men and women, vascular pathologies only slightly outweighed the risk related to lipids. This suggests a complex gender-specific pattern of cognitive decline involving genetic vulnerability in men and hormonal status in women.

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Section: Discussionsupporting

confidence: 86%

Gender-specific associations between lipids and cognitive decline in the elderly

Ancelin

Ripoche

Dupuy

et al. 2014

European Neuropsychopharmacology

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“…Based on the Wallerian degeneration hypothesis and on the AD neuronal degeneration pattern [103,104], the posterior CC subregions should be involved in the earlier stages of the disease and the anterior CC subregions only in the later stages. Nevertheless, several studies [20,21,82,89] found that a reduction in the genu of the CC was already present in the early and preclinical stages of AD.…”

Section: Possible Underlying Mechanismsmentioning

confidence: 99%

“…One study on MCI "all subtypes" [89] found a significant change in MD and FA in the genu and the splenium of the CC in patients compared with HC. Moreover, studies on amnesic MCI [83,86,90] mainly found a decreased FA and/or increased MD value in the splenium of the CC.…”

Section: Diffusion-weighted Imaging and Diffusion Tensor Imaging Studiesmentioning

confidence: 99%

“…At present, the DTI study results on MCI patients can be divided into two groups: 1) DTI studies on both amnesic and MCI "all subtypes" [23,40,41,84,85,88] that found no differences in MD and/or in FA in the CC compared with HC; and 2) the most recent studies [83,86,[89][90][91], which reported differences. One study on MCI "all subtypes" [89] found a significant change in MD and FA in the genu and the splenium of the CC in patients compared with HC.…”

Section: Diffusion-weighted Imaging and Diffusion Tensor Imaging Studiesmentioning

confidence: 99%

“…Another aspect that can in part explain the variability in the results of DWI and DTI studies is how accurate the studies are in determining the location of changes. The latter can be inferred basically from ROI analyses [40,41,89], voxel-wise comparisons [32,82,84], or projecting diffusion values onto a tract-based template (TBSS) [85]. These approaches, however, all make assumptions about the correspondence of tract locations across subjects [121].…”

Section: Limitations Of the Techniquesmentioning

confidence: 99%

See 2 more Smart Citations

In Vivo Structural Neuroanatomy of Corpus Callosum in Alzheimer's Disease and Mild Cognitive Impairment Using Different MRI Techniques: A Review

Paola

Spalletta

Caltagirone

2010

JAD

129

103

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Abstract. The corpus callosum (CC), which connects the two cerebral hemispheres, is the largest white matter fiber bundle in the human brain. This structure presents a peculiar myelination pattern: it has small diameter fibers, located in the genu, which myelinate much later in normal development, and large diameter fibers of the splenium, which myelinate early in development. Although the pathology of AD mainly involves the cerebral gray matter structure, there is evidence that white matter may also be involved. To illustrate callosal white matter changes in AD pathology, in this review we summarize in vivo imaging studies in humans, focusing on region of interest, voxel-based morphometry, diffusion-weighted imaging, and diffusion tensor imaging techniques. Our aims were to identify where in the CC, when in the different stages of AD, and how callosal changes can be detected with different MRI techniques. Results showed that changes in the anterior (genu and anterior body) as well as in the posterior (isthmus and splenum) portions of the CC might already be present in the early stages of AD. These findings support the hypothesis that two mechanisms, Wallerian degeneration and myelin breakdown, might be responsible for the region-specific changes detected in AD patients. Wallerian degeneration affects the posterior CC subregion, which receives axons directly from those brain areas (temporo-parietal lobe regions) primarily affected by the AD pathology. Instead, the myelin breakdown process affects the later-myelinating CC subregion and explains the earlier involvement of the genu in CC atrophy.

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Chemotherapy‐induced structural changes in cerebral white matter and its correlation with impaired cognitive functioning in breast cancer patients

Deprez

Amant

Yigit

et al. 2011

Human Brain Mapping

247

183

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A subgroup of patients with breast cancer suffers from mild cognitive impairment after chemotherapy. To uncover the neural substrate of these mental complaints, we examined cerebral white matter (WM) integrity after chemotherapy using magnetic resonance diffusion tensor imaging (DTI) in combination with detailed cognitive assessment. Postchemotherapy breast cancer patients (n = 17) and matched healthy controls (n = 18) were recruited for DTI and neuropsychological testing, including the self-report cognitive failure questionnaire (CFQ). Differences in DTI WM integrity parameters [fractional anisotropy (FA) and mean diffusivity (MD)] between patients and healthy controls were assessed using a voxel-based two-sample-t-test. In comparison with healthy controls, the patient group demonstrated decreased FA in frontal and temporal WM tracts and increased MD in frontal WM. These differences were also confirmed when comparing this patient group with an additional control group of nonchemotherapy-treated breast cancer patients (n = 10). To address the heterogeneity observed in cognitive function after chemotherapy, we performed a voxel-based correlation analysis between FA values and individual neuropsychological test scores. Significant correlations of FA with neuropsychological tests covering the domain of attention and processing/psychomotor speed were found in temporal and parietal WM tracts. Furthermore, CFQ scores correlated negatively in frontal and parietal WM. These studies show that chemotherapy seems to affect WM integrity and that parameters derived from DTI have the required sensitivity to quantify neural changes related to chemotherapy-induced mild cognitive impairment.

show abstract

Difference of the hippocampal and white matter microalterations in MCI patients according to the severity of subcortical vascular changes: Neuropsychological correlates of diffusion tensor imaging

Cited by 40 publications

References 56 publications

Gender-specific associations between lipids and cognitive decline in the elderly

Gender-specific associations between lipids and cognitive decline in the elderly

In Vivo Structural Neuroanatomy of Corpus Callosum in Alzheimer's Disease and Mild Cognitive Impairment Using Different MRI Techniques: A Review

Chemotherapy‐induced structural changes in cerebral white matter and its correlation with impaired cognitive functioning in breast cancer patients

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