Differences between polydioxanone and poliglactin in intestinal anastomoses – a comparative study of intestinal anastomoses

Abstract

Introduction Intestinal anastomosis is a surgical practice constantly realized by surgeons worldwide. When the option is to perform manual anastomosis, which is still widely used for its low cost, the question arises as to the best material to be applied. Objective To compare polydioxanone and polyglactin threads for healing and tensile strength in intestinal anastomosis in rats. Method We used 25 rats Wistar; after anesthesia, in groups A and B (10 rats each), laparotomy was performed, transection of the ileum at 5 and 10 cm proximally to the ileocecal valve; in group A, anastomosis was performed with 4 separate extra mucosal sutures with polidioxanone; in group B, anastomosis was performed with polyglactin; in group C (5 rats), laparotomy and manipulation of the ileum were performed. After 21 days, the animals were anesthetized and submitted to euthanasia. The specimens were sent for histopathological study and tensile strength analysis. Statistical analysis was performed using the Turkey and Student's t tests, with a significance of p < 0.05. Results The results showed that in the tensile strength analysis, there were no significant differences between them. The histological analysis showed significant differences between the cicatrization pattern, where polydioxanone caused less fibrosis than polyglactin. Conclusion Polydioxanone caused less fibrosis than polyglactin in intestinal anastomoses of rats.

Outcomes Assessment between Hand Sewn and Stapled Intestinal Anastomosis

“…The comparison of hand sewn with stapled anastomosis seemed to be zero differences between each other. The hand suturing methods were obviously revealed to exhibit an extensive learning curve as compared to stapling methods [5]. The characteristic of intestinal suturing method which has continuously still controversial is the usage of either two layers or one suture layer for anastomosis.…”

Features of Microsurgical Anatomy of the Small Intestine in Experimental Widespread Purulent Peritonitis

“…Актуальность обусловлена большим количеством осложнений, развивающихся в раннем послеоперационном периоде и, прежде всего, несостоятельности кишечных швов, достигающей 42% [2,3,6,7,9,10]. Указанные обстоятельства побуждают хирургов к поиску методов улучшения результатов лечения больных с перитонитом, разработке методик, направленных на предотвращение несостоятельности кишечного шва [11,13,14].…”

Synthesis and Characterization of Hybridfiber from Gelatin Modified by PVACOS Using Coaxial Electrospinning Techniques as an Advanced Medical Textile Material

“…Research that has been carried out on materials that can be used to make medical textile fibers includes cow intestine [4], gelatin [5], alginate [6], sericin [7], cyclodextrin [8], triclocan [9], polydioxanone [10], nylon [11], polypropylene [12], and polyester polymer [13]. Among these materials, namely cow intestine, gelatin, and alginate, are sources of renewable materials.…”