Differences in adrenal steroid profile in chronic fatigue syndrome, in depression and in health

Scott, Lucinda V.; Salahuddin, Farah F.; Cooney, John; Švec, František; Dinan, Timothy G.

doi:10.1016/s0165-0327(98)00169-4

Cited by 74 publications

(36 citation statements)

References 43 publications

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“…These results do not support earlier findings that higher levels of DHEA(S) are positively associated with a positive affect (32), positive well-being, and better physical and mental health (33), and negatively associated with depression (34,35) and with chronic fatigue syndrome (35)(36)(37). Nor did Grossi et al (18) report any deviations in DHEAS in participants with a high burnout score.…”

Section: Discussioncontrasting

confidence: 60%

“…It has a long biological half-time (7-10 hours) and displays a weak circadian rhythm (31). Higher levels of DHEA(S) have been shown to be positively associated with positive affect (32), positive well-being, and better physical and mental health (33), whereas lower DHEAS levels have been found in depression (34,35) and in chronic fatigue syndrome (35)(36)(37). It can thus be expected that work engagement is positively associated with DHEAS levels and negatively associated with burnout.…”

mentioning

confidence: 99%

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Do burned-out and work-engaged employees differ in the functioning of the hypothalamic-pituitary-adrenal axis?

Langelaan¹,

Bakker²,

Wb³

et al. 2006

Scand J Work Environ Health

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Section: Discussioncontrasting

confidence: 60%

mentioning

confidence: 99%

Do burned-out and work-engaged employees differ in the functioning of the hypothalamic-pituitary-adrenal axis?

Langelaan¹,

Bakker²,

Wb³

et al. 2006

Scand J Work Environ Health

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“…94,95 Divergent results in HPA axis measures in mood disorders may be due to some variability of clinical characteristics such as subtypes of depression (endogenous vs psychoses vs atypical), 75,96,97 chronicity of illness, 98 the presence of anxiety symptoms, 68,99 recurrence of depressive episodes, 100 severity of symptoms, 96,101 age-dependent 102 and sampling factors (in-patients vs outpatients). 67,75,[103][104][105][106] HPA axis hyperactivity may play an important role in the pathogenesis of major depression. This hyperactivity is believed to be secondary to hypersecretion of CRH.…”

Section: Neuroendocrine Dysregulations In Patients With Mddmentioning

confidence: 99%

Brain-immune interactions and disease susceptibility

2005

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Many studies have established the routes by which the immune and central nervous (CNS) systems communicate. This network of connections permits the CNS to regulate the immune system through both neuroendocrine and neuronal pathways. In turn, the immune system signals the CNS through neuronal and humoral routes, via immune mediators and cytokines. This regulatory system between the immune system and CNS plays an important role in susceptibility and resistance to autoimmune, inflammatory, infectious and allergic diseases. This review focuses on the regulation of the immune system via the neuroendocrine system, and underlines the link between neuroendocrine dysregulation and development of major depressive disorders, autoimmune diseases and osteoporosis.

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“…Epidemiological studies found plasma concentrations of dehydroepiandrosterone (DHEA) and its sulfated form (DHEA-S) to be negatively associated with depressive symptoms [2]. In contrast, most -albeit not all [3,4] -clinical studies have reported increased plasma and urine concentrations of DHEA and DHEA-S in depressed patients [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Antidepressant Treatment and Dehydroepiandrosterone Sulfate: Different Effects of Amitriptyline and Paroxetine

Deuschle

Luppa²,

Gilles

et al. 2004

Neuropsychobiology

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Background: There is evidence for activation of the hypothalamus-pituitary-adrenal system in depressed patients to be associated with increased secretion of adrenal androgens. However, there is only limited information about the effect of different classes of antidepressants on the course of adrenal androgens. Methods: Dehydroepiandrosterone sulfate (DHEA-S) serum concentrations were measured in 80 patients being treated with amitriptyline (AMI) or paroxetine (PAROX) for a period of 35 days. Results: Using analysis of variance with repeated measures, we found a significant effect of treatment upon DHEA-S serum concentrations that declined more in AMI-treated (before vs. after: 1.89 ± 1.16 vs. 1.46 ± 0.96 mg/l), compared to PAROX-treated patients (1.56 ± 1.09 vs. 1.50 ± 1.04 mg/l). Conclusions: Our results show changes in DHEA-S serum concentrations during antidepressant treatment to depend on medication.

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Differences in adrenal steroid profile in chronic fatigue syndrome, in depression and in health

Cited by 74 publications

References 43 publications

Do burned-out and work-engaged employees differ in the functioning of the hypothalamic-pituitary-adrenal axis?

Do burned-out and work-engaged employees differ in the functioning of the hypothalamic-pituitary-adrenal axis?

Brain-immune interactions and disease susceptibility

Antidepressant Treatment and Dehydroepiandrosterone Sulfate: Different Effects of Amitriptyline and Paroxetine

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