Differences in antimicrobial consumption, prescribing and isolation rate of multidrug resistant Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii on surgical and medical wards

Živanovic, V.; Gojkovic-Bukarica, Ljiljana; Šćepanović, Radisav; Vitorović, Teodora; Novaković, R; Milanov, Nenad; Bukumirić, Zoran; Carević, Biljana; Trajkovic, Jasmina; Rajković, Jovana; Djokic, Vladimir

doi:10.1371/journal.pone.0175689

Cited by 8 publications

(8 citation statements)

References 16 publications

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“…Most treatments were empirical for both healthcare- and community-acquired infections. This finding is consistent with recent data from Africa [ 42 ] and other developing countries [ 43 , 44 ]. Empirical treatment for community-acquired infections had a higher proportion compared to empirical treatment for healthcare-acquired infections.…”

Section: Discussionsupporting

confidence: 93%

Point Prevalence Survey of Antimicrobial Utilization in Ghana’s Premier Hospital: Implications for Antimicrobial Stewardship

et al. 2021

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The first comprehensive point prevalence survey at the Korle Bu Teaching Hospital (KBTH) was performed as part of the 2019 Global Point Prevalence Survey (Global-PPS) on antimicrobials. The aim was to establish a PPS baseline for the whole hospital and to identify required stewardship interventions. The PPS was conducted over three days in June 2019 using the GLOBAL-PPS standardized method for surveillance of antimicrobial utilization in hospitals to evaluate antimicrobial prescribing. In all, 988 patients were admitted to 69 wards. Overall antimicrobial prevalence was 53.3%. More community-acquired infections (CAI) were treated empirically compared to health-care associated infections (94.0% vs. 86.1% respectively, p = 0.002). Main indications for prescribing antimicrobials were pneumonia (18.4%), skin and soft tissue infections (11.4%) and sepsis (11.1%). Among antimicrobials, systemic antibiotics accounted for 83.5%, of which amoxicillin with beta-lactam inhibitor (17.5%), metronidazole (11.8%) and ceftriaxone (11.5%) dominated. Guideline compliance was 89.0%. Stop/review dates were completed in 33.4% and documented reason was recorded in 53.0% of all prescriptions. If the findings in this PPS can be addressed antimicrobial stewardship at the KBTH stands to improve significantly.

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Section: Discussionsupporting

confidence: 93%

Point Prevalence Survey of Antimicrobial Utilization in Ghana’s Premier Hospital: Implications for Antimicrobial Stewardship

et al. 2021

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“…According to a WHO report in 2013, among EU-countries the highest prevalence of K. pneumoniae resistant to the third generation cephalosporines (88.5%) and a very high prevalence of K. pneumoniae, P. aeruginosa and A. baumannii resistant to carbapenems (31.4%, 44.6% and 92.1%, respectively) was already described. In addition, the percentages of multi drug resistant (MDR) pathogens relative to the total number of isolates were higher on the surgical wards where the urinary tract, gastrointestinal tract and skin and soft tissue infections were the most frequently diagnosed [23,24]. By contrast, in the hospital in the study, MDR pathogens have been particularly encountered in the intensive care unit, where the main etiologic agent of respiratory infections was A. baumannii [25].…”

Section: Discussionmentioning

confidence: 99%

Antibiotic Consumption and Microbiological Epidemiology in Surgery Departments: Results from a Single Study Center

et al. 2020

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The spectrum and antibiotic sensitivity of isolated strains vary between departments, hospitals, countries; the discrepancies are related to the use and dosage of these antibiotics. The purpose of our research was to compare the type of pathogens and the susceptibility of the isolated strains, as well as the use of antibiotics in the surgical departments of the Emergency Clinical County Hospital, Oradea, Romania; for one year, all the patients admitted to the mentioned sections were monitored. Antibiotic sensitivity of isolated strains was expressed using cumulative antibiogram. The total consumption of antibiotics was 479.18 DDD/1000 patient-days in the surgical sections. The most commonly used drugs were cephalosporins third and first generation, and clindamycin. Infections of wounds, urinary tract and fluids were most commonly diagnosed, and the most isolated was Escherichia coli, followed by Staphylococcus aureus and Enterococcus faecalis. The most commonly prescribed antimicrobial was ceftriaxone, but its sensitivity was low. This study revealed that the intake of antimicrobials in the surgical sections is increased and the comparison of antimicrobial prescriptions, sensitivity rates, and the spectrum of isolated pathogens showed differences between antimicrobials.

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“…Infection control measures or scheduled surveillance can reduce the incidence of nosocomial infections [12,13].…”

Section: Discussionmentioning

confidence: 99%

“…Epidemiological studies showing data regarding the burden and existing resistance mechanisms, more than 2 million people or 5% to 10% of hospitalized patients are affected by nosocomial infections with an estimated 90,000 deaths with overall 29% mortality rate every year [13]. The mortality rate of our trauma/ surgical intensive care unit patients (27.3%) was higher than Thailand (20%) [130].…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of ESBL producing MDR E. coli and Klebsiellae pneumonae from clinical isolates of nosocomial hospital acquired infections

Taara

Aqsa

lashari

et al. 2020

GSC Biol. and Pharm. Sci.

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The impact of nosocomial infections (NIs) is an important public health concern due to emergence of new MDR strains of pathogens and approximately 5 to 10% of hospitalized patients are affected by NIs. 90,000 deaths per year in United States only warrant investigation. This study was a hospital based cross sectional study to determine the ESBL producing MDR nosocomial infection and their control from Jun 1st2016 to Dec31st 2017. 500 patients were investigated all demographic data was collected from patients with a history of hospital admission for ≥ 2 days. In this study out of total 500 patients, (62%) patients were female and (38%) were males, 19% isolates were E.coli and 18% were K.pneumonae all were MDR along with other pathogens .most of strains were showing 55%-85% resistance for more than one antibiotics. PCR studies show that SHV (32%) and TEM (18%) genes were found in ESBLs producing organisms. Due to importance of ESBL producing organisms and difficult treatment of infections caused by these bacteria rapid identification of ESBL producing strains should be adopted in enterobacteraciae, infection control strategies are recommended to adopt and warrant investigation.

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Differences in antimicrobial consumption, prescribing and isolation rate of multidrug resistant Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii on surgical and medical wards

Cited by 8 publications

References 16 publications

Point Prevalence Survey of Antimicrobial Utilization in Ghana’s Premier Hospital: Implications for Antimicrobial Stewardship

Point Prevalence Survey of Antimicrobial Utilization in Ghana’s Premier Hospital: Implications for Antimicrobial Stewardship

Antibiotic Consumption and Microbiological Epidemiology in Surgery Departments: Results from a Single Study Center

Prevalence of ESBL producing MDR E. coli and Klebsiellae pneumonae from clinical isolates of nosocomial hospital acquired infections

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