Differences in Body Composition and Resting Energy Expenditure in Childhood in Preterm Children Born with Very Low Birth Weight

Sepúlveda, Carolina; Urquidi, Cinthya; Pittaluga, E; Íñiguez, Germán; Ávila, Alejandra; Carrasco, Fernando; Mericq, Verónica

doi:10.1159/000351466

Cited by 22 publications

(29 citation statements)

References 20 publications

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“…In line with previous studies [23,24,25], the present study showed that, in preterm infants, higher weight gain during the first 6 months after term age resulted in higher FM and higher leptin at 6 months' CA. In contrast with Hernandez et al [26], weight gain during the first 6 months after term age was positively associated with FM and leptin in both SGA and AGA preterm infants.…”

Section: Discussionsupporting

confidence: 93%

Relationship between Fat Mass Measured by Dual-Energy X-Ray Absorptiometry and Leptin in Preterm Infants between Term Age and 6 Months' Corrected Age

Poelje

Lagemaat²,

Lafeber³

et al. 2014

Horm Res Paediatr

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Background/Aims: In term subjects, fat mass (FM) is positively associated with leptin, whereas studies in preterm infants show conflicting results. However, none of these studies measured FM by dual-energy X-ray absorptiometry (DEXA). This study aims to relate FM measured by DEXA in relation to leptin and growth in preterm infants. Methods: In 139 preterm infants, weight (kg) and length (cm) were measured at birth, term age, and 6 months' corrected age (CA). FM (kg), measured by whole-body DEXA, and leptin (µg/l) were measured at term age and 6 months' CA. Results: At term age and 6 months' CA, FM was associated with leptin (β = 1.94, 95% CI: 1.51-2.36, and β = 0.37, 95% CI: 0.26-0.48, respectively; p < 0.001). Gain in weight standard deviation score (SDS) between term age and 6 months' CA was associated with FM and leptin at 6 months' CA (β = 0.24, 95% CI: 0.18-0.30, and β = 0.25, 95% CI: 0.16-0.33, respectively; p < 0.001). Conclusion: In preterm infants, FM measured by DEXA is associated with leptin, which indicates that leptin is a marker of body FM during the first 6 months after term age. Gain in weight SDS between term age and 6 months' CA results in higher FM and higher leptin at 6 months' CA.

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Section: Discussionsupporting

confidence: 93%

Relationship between Fat Mass Measured by Dual-Energy X-Ray Absorptiometry and Leptin in Preterm Infants between Term Age and 6 Months' Corrected Age

Poelje

Lagemaat²,

Lafeber³

et al. 2014

Horm Res Paediatr

View full text Add to dashboard Cite

show abstract

“…Consistent with these findings, Sepulveda et al (25) found a positive association between weight gain in the first 3 months of life and total fat in 67 preterm children born with very low birthweights and assessed at 6 years of age using dual-energy X-ray absorptiometry. On the contrary, we did not find any correlation between delta weight gain at an equivalent term age of 6 months and body composition parameters.…”

Section: Discussionmentioning

confidence: 64%

Boys who are born preterm show a relative lack of fat-free mass at 5 years of age compared to their peers

et al. 2014

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“…Rapid weight gain in early infancy increases future cardiometabolic risk [1,2,3,4] and predicts obesity in later childhood [5,6], adolescence and adulthood [7,8]. There is also evidence that the metabolic consequences of obesity can begin in childhood, as it is associated with increased inflammatory markers [9], immune dysregulation [10] and hypertension [11,12] from an early age.…”

Section: Introductionmentioning

confidence: 99%

Body Composition within the First 3 Months: Optimized Correction for Length and Correlation with BMI at 2 Years

Hawkes¹,

Zemel²,

Kiely³

et al. 2016

Horm Res Paediatr

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Background/Aims: Although early infant growth has implications for future health, body composition reference data in infancy are limited. The aim of this study was to describe reference data for fat mass (FM) and fat-free mass (FFM) corrected for length (L) within the first 3 months and to evaluate if these measures predict the body mass index (BMI) at 2 years. Methods: Term infants had air displacement plethysmography performed at birth (n = 1,063) and approximately 2 months later (n = 922, between 49 and 86 days). Age- and sex-specific reference data were generated for FM, FFM, FM/L³ and FFM/L² and compared with BMI at 2 years. Results: FM/L³ and FFM/L² were the optimal indices independent of length. In the first 3 months, mean FM/L³ increased (males, from 2.7 to 5.9 kg/m³; females, from 3.2 to 6.1 kg/m³), whereas FFM/L² remained relatively stable (males, from 11.8 to 12.7 kg/m²; females, from 12.8 to 12.1 kg/m²). The odds of a BMI Z-score ≥2 at 2 years increased with increasing FM (OR 2.7, 95% CI 1.97-3.7) and weight (OR 2.27, 95% CI 1.64-3.13) Z-scores at 2 months. Conclusions: FM/L³ and FFM/L² provide length-independent measures of FM and FFM in infancy. During the first 3 months, there is an increase in FM/L³, but not in FFM/L². The weight Z-score at 2 months is as good at predicting BMI at 2 years as body composition parameters.

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Differences in Body Composition and Resting Energy Expenditure in Childhood in Preterm Children Born with Very Low Birth Weight

Cited by 22 publications

References 20 publications

Relationship between Fat Mass Measured by Dual-Energy X-Ray Absorptiometry and Leptin in Preterm Infants between Term Age and 6 Months' Corrected Age

Relationship between Fat Mass Measured by Dual-Energy X-Ray Absorptiometry and Leptin in Preterm Infants between Term Age and 6 Months' Corrected Age

Boys who are born preterm show a relative lack of fat-free mass at 5 years of age compared to their peers

Body Composition within the First 3 Months: Optimized Correction for Length and Correlation with BMI at 2 Years

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