Differences in cardiorespiratory and neuromuscular responses between voluntary and stimulated contractions of the quadriceps femoris muscle

Theurel, Jean; Lepers, Romuald; Pardon, Laurent; Maffiuletti, Nicola A.

doi:10.1016/j.resp.2006.12.002

Cited by 83 publications

(88 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the last few years, NMES has been used in rehabilitation, geriatric and sport medicine (for review, (9, 10)), with the general objectives to a) minimize the effects of prolonged immobilization or disuse on skeletal muscle structure and function and b) improve neuromuscular function parameters in healthy individuals. More recently, the acute effects of NMES on neuromuscular, metabolic and hormonal responses have also received attention (11)(12)(13). We have demonstrated that a single bout of NMES exercise is able to show GH responsiveness in healthy subjects (13).…”

Section: Introductionmentioning

confidence: 94%

GH responses to two consecutive bouts of neuromuscular electrical stimulation in healthy adults

Sartório

Jubeau

Agosti

et al. 2008

European Journal of Endocrinology

View full text Add to dashboard Cite

Background: It is well established that repeated GHRH administration or repeated voluntary exercise bouts are associated with a complete blunting of GH responsiveness when the administration of the second stimulus follows the first one after a 2-h interval. Aim: To evaluate GH responses to neuromuscular electrical stimulation (NMES) in healthy adults. Methods: Six volunteers (mean ageGS.D. 31.7G5.5 years) were studied before and after two consecutive bouts of NMES exercise (a series of 20 contractions at the maximum of individual tolerance, frequency: 75 Hz, pulse duration: 400 ms, on-off ratio: 6.25-20 s) administered at a 2-h interval. Results: Baseline GH levels (mean: 0.3G0.2 ng/ml) significantly increased after the first NMES (peak: 4.2G3.7 ng/ml), with a complete normalization after 120 min (0.3G0.3 ng/ml). The administration of the second bout of NMES of comparable characteristics also resulted in a significant GH increase (peak: 5.2G3.2 ng/ml), which was comparable with that observed after the previous one. GH net incremental area under the curve after the first and second bouts of NMES were not significantly different (155.1G148.5 and 176.9G123.3 ng/ml per h, PZ0.785). Conclusions: Unlike repeated pharmacological stimuli and voluntary exercise bouts, subsequent sessions of NMES administered at a 2-h interval appear to circumvent feedback mechanisms and to re-induce the GH responses, thus indicating a possible different underlying mechanism elicited by different GH-releasing stimuli.

show abstract

Section: Introductionmentioning

confidence: 94%

GH responses to two consecutive bouts of neuromuscular electrical stimulation in healthy adults

Sartório

Jubeau

Agosti

et al. 2008

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…In healthy humans, Theurel et al 2007 reported a doubling in cardiovascular demand with high-frequency (70 Hz) NMES applied to the quadriceps. High-frequency NMES has also been used, with some success, as an alternative to cardiovascular exercise in hypoactive patients with severe chronic obstructive pulmonary disease (COPD) (Bourjeily-Habr et al 2002;Neder et al 2002;Sillen et al 2008Sillen et al , 2009Zanotti et al 2003) and critical illness polyneuromyopathy (Gerovasili et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Comparative effect of a 1 h session of electrical muscle stimulation and walking activity on energy expenditure and substrate oxidation in obese subjects

Grosset

Crowe

Vito

et al. 2013

Appl. Physiol. Nutr. Metab.

View full text Add to dashboard Cite

It has previously been shown that low-frequency neuromuscular electrical stimulation (NMES) techniques can induce increases in energy expenditure similar to those associated with exercise. This study investigated the metabolic and cardiovascular effects of a 1 h session of lower limb NMES and compared cardiovascular response with that observed during walking in nine obese subjects (three males) (age = 43.8 ± 3.0 years; body mass index (BMI) = 41.5 ± 1.8 kg/m 2 ). The NMES protocol consisted of delivering a complex pulse pattern to the thigh muscles for 1 h. The walking test consisted of five 4-min bouts starting at 2 km/h with 1 km/h increments up to 6 km/h. In both tests, an open-circuit gas analyser was used to assess O 2 consumption (V O 2 ), CO 2 production (V CO 2 ), respiratory exchange ratio (RER), and heart rate (HR). Rates of fat oxidation (RFO) and carbohydrate oxidation (CHO) were estimated by indirect calorimetry. One hour of NMES significantly increased V O 2 , HR, RER, and mean energy expenditure compared with resting values, reaching 8.7 ± 1.3 mL·min −2 ·kg −1 (47% of V O 2peak ), 114.8 ± 7.5 bpm, 0.95, and 318.5 ± 64.3 kcal/h, respectively. CHO, but not RFO, increased during 1 h of NMES. With NMES, CHO was greater and RFO was less than at all walking speeds except 6 km/h. Lactate also increased more with NMES, to 3.5 ± 0.7 mmol versus a maximum of 1.5 ± 0.3 mmol with the walking protocol. These results suggest that NMES can be used in an obese population to induce an effective cardiovascular exercise response. In fact, the observed increase in energy expenditure induced by 1 h of NMES is clinically important and comparable with that recommended in weight management programs.Key words: obesity, neuromuscular electrical stimulation, oxygen consumption, energy expenditure, substrate oxidation. Mots-clés : obésité, stimulation électrique neuromusculaire, consommation d'oxygène, dépense énergétique, oxydation des substrats.

show abstract

“…On the other hand, Nuhr et al (35) reported an improved work capacity and O 2 uptake (V O 2 ) at the anaerobic threshold following NMES. Compared with voluntary contractions of the same intensity, it has been reported that contractions obtained by NMES are associated with a greater (30, 32) or similar (33) metabolic demand, and with an increased blood flow during recovery (32,45).In the light of these controversial results, Gondin et al (12) performed a comprehensive in vitro evaluation of the skeletal muscle phenotypic adaptations following a training program by NMES. These authors observed the following (12): increases in maximum voluntary force and neural activation; muscle fibers hypertrophy; a fast-to-slow transition of muscle fiber types, as determined on the basis of myosin heavy chain (MHC) isoforms; a fast-to-slow phenotype shift in the expression of myofibrillar proteins; a glycolytic-to-oxidative shift in metabolic profile; and an enhancement of intracellular defenses against reactive oxygen species.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

Lack of functional effects of neuromuscular electrical stimulation on skeletal muscle oxidative metabolism in healthy humans

Porcelli

Marzorati

Pugliese

et al. 2012

Journal of Applied Physiology

View full text Add to dashboard Cite

-A recent study has demonstrated that neuromuscular electrical stimulation (NMES) determines, in vitro, a fast-to-slow shift in the metabolic profile of muscle fibers. The aim of the present study was to evaluate if, in the same subjects, these changes would translate, in vivo, into an enhanced skeletal muscle oxidative metabolism. Seven young men were tested (cycle ergometer) during incremental exercises up to voluntary exhaustion and moderate and heavy constant-load exercises (CLE). Measurements were carried out before and after an 8-wk training program by isometric bilateral NMES (quadriceps muscles), which induced an ϳ25% increase in maximal isometric force. Breathby-breath pulmonary O2 uptake (V O2) and vastus lateralis oxygenation indexes (by near-infrared spectroscopy) were determined. Skeletal muscle fractional O2 extraction was estimated by near-infrared spectroscopy on the basis of changes in concentration of deoxygenated hemoglobin ϩ myoglobin. Values obtained at exhaustion were considered "peak" values. The following functional evaluation variables were unaffected by NMES: peak V O2; gas exchange threshold; the V O2 vs. work rate relationship (O2 cost of cycling); changes in concentration of deoxygenated hemoglobin ϩ myoglobin vs. work rate relationship (related to the matching between O2 delivery and V O2); peak fractional O2 extraction; V O2 kinetics (during moderate and heavy CLE) and the amplitude of its slow component (during heavy CLE). Thus NMES did not affect several variables of functional evaluation of skeletal muscle oxidative metabolism. Muscle hypertrophy induced by NMES could impair peripheral O2 diffusion, possibly counterbalancing, in vivo, the fast-to-slow phenotypic changes that were observed in vitro, in a previous work, in the same subjects of the present study. strength training; muscle hypertrophy; near-infrared spectroscopy; gas exchange kinetics NEUROMUSCULAR ELECTRICAL STIMULATION (NMES) (26, 28) is widely utilized as a complement to voluntary exercise in athletes (27) and in patients, such as those with heart failure (46), chronic obstructive pulmonary disease (34), or cancer (6). NMES represents an obligatory choice for training in patients who cannot perform voluntary contractions, such as those with spinal cord lesions (10), or in patients immobilized for fractures or following ligament reconstruction surgery (42). It is well established that NMES leads to significant increases in muscle mass and maximal voluntary strength (13,26,39).The effects of NMES on oxidative metabolism appear rather controversial. At molecular level, Perez et al. (36) reported a higher succinic dehydrogenase activity after NMES training, whereas both citrate synthase and phosphofructokinase activities were unchanged. Kim et al. (21) reported, after a NMES training program, no changes in citrate synthase activity and number of capillaries. Nuhr et al. (35) showed an increase in the activity of citrate synthase associated with a decrease in the activity of glyceraldehyde phosphate dehydrogenase. Int...

show abstract

Differences in cardiorespiratory and neuromuscular responses between voluntary and stimulated contractions of the quadriceps femoris muscle

Cited by 83 publications

References 27 publications

GH responses to two consecutive bouts of neuromuscular electrical stimulation in healthy adults

GH responses to two consecutive bouts of neuromuscular electrical stimulation in healthy adults

Comparative effect of a 1 h session of electrical muscle stimulation and walking activity on energy expenditure and substrate oxidation in obese subjects

Lack of functional effects of neuromuscular electrical stimulation on skeletal muscle oxidative metabolism in healthy humans

Contact Info

Product

Resources

About