Differences in hepatitis E virus (HEV) presence in naturally infected seropositive domestic pigs and wild boars - an indication of wild boars having an important role in HEV epidemiology

Jemeršić, Lorena; Keros, Tomislav; Maltar, Ljupka; Barbić, Ljubo; Čavlek, Tatjana Vilibić; Jeličić, Pavle; Rode, Oktavija Đaković; Prpić, Jelena

doi:10.24099/vet.arhiv.170208

Cited by 20 publications

(23 citation statements)

References 27 publications

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“…A lower seroprevalence of 32.94% was detected in swine in Croatia [11] and 40% in Bulgaria [12] but very similar seroprevalence (58.1%), as in our investigation, was demonstrated in Switzerland [25]. On the other hand, higher seroprevalence of 80% was established in fattening pigs in northern Greece [26].…”

Section: Discussionsupporting

confidence: 84%

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Seroprevalence of hepatitis E in pigs and wild boars in the region of the city Belgrade

Kureljušić¹,

Savić²,

Jezdimirović³

et al. 2020

J Infect Dev Ctries

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Introduction: Hepatitis E is considered an emerging human viral disease with many evidences of zoonotic nature of disease, and swine are the main reservoir of HEV. The aim of this study was to determine HEV seroprevalence in commercial pig farms, backyard pigs, slaughtered pigs and wild boars in the region of the city Belgrade. Methodology: A total of 405 sera samples: 150 samples from 3 commercial pig farms, 70 samples from backyard pigs, 119 samples from slaughtered pigs and 66 samples from wild boars of the region of the city Belgrade, Serbia were analysed by commercial ELISA test. Results: The overall HEV seroprevalence in 3 commercial pig farms was 55.33% (83/150). All tested farms (farm A, B and C) were positive on the presence of anti-HEV antibodies, respectively 58% (29/50), 54% (27/50) and 54% (27/50). From 70 tested backyard pigs, 75.71% (53/70) were tested seropositive. In total, 26 backyard pig holidngs were confirmed as positive to anti-HEV antibodies (81.25%). At slaughterhouse, 25% (8/32) weaned piglets and 20.69% (18/87) fattening pigs were tested positive on anti-HEV antibodies. Overall HEV seroprevalence in tested wild boar population was 52.25% (36/66). Conclusions: Detected very high seroprevalence of anti-HEV antibodies indicated an active circulation of HEV, being enzootic in the swine population, and wild boars, as well, in the region of the city Belgrade.

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Section: Discussionsupporting

confidence: 84%

“…HEV infection is highly prevalent among the domestic pigs in Europe. Jemeršić et al [11] reported that the overall seroprevalence in Croatia was 32.94%. In Bulgaria, the total seroprevalence of HEV in pigs 1 to 6 months of age was 40%, being in piglets 50% and in fattening pigs 29.2% [12].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of hepatitis E in pigs and wild boars in the region of the city Belgrade

Kureljušić¹,

Savić²,

Jezdimirović³

et al. 2020

J Infect Dev Ctries

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“…Zele et al reported HEV seroprevalence 30.21% (87/288) of wild boar serum samples from Slovenia [18]. Jemersic et al found 31.10% (311/1000; 95% CI: 28.31-34.04) HEV-positive wild boars in 6 of the 16 counties of Croatia [19]. Moderate and high HEV seropositivity among domestic pigs was observed in Southeastern Europe [20].…”

Section: Discussionmentioning

confidence: 99%

High Seroprevalence of Hepatitis E Virus Infection Among East Balkan Swine (Sus scrofa) in Bulgaria: Preliminary Results

et al. 2020

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The East Balkan swine (Sus scrofa) is the only aboriginal pig breed in Bulgaria, and it is indigenous to the eastern part of the country. The aim of the present study was to investigate East Balkan swine (EBS) in Bulgaria for serological evidence of hepatitis E virus (HEV). Sera from 171 swine from two parts of the country (northeastern and southeastern) were tested for anti-HEV IgG antibodies. The overall HEV seroprevalence was 82.5% (141/171), and for weaners it was 77.2% (44/57), for fattening pigs 79.0% (45/57), and for adults 91.2% (52/57). HEV positivity was higher in fattening pigs and adults compared to weaners: OR = 1.108 (95% CI: 0.456–2.692) and OR = 3.073 (95% CI: 1.016–9.294), respectively. This study provides the first evidence of exposure to HEV in EBS from Bulgaria.

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“…In 2016, the overall HEV seroprevalence was shown to be 32.94% (range 8.33%-60.00%) in domestic pigs from 11 counties and 31.10% (range 7.70%-50.60%) in wild boars from six Croatian counties. While no positive HEV RNA samples were detected in domestic pigs, 11.33% seropositive wild boars were found to be HEV RNA positive indicating that wild boars may have a key role in HEV epidemiology[41].…”

Section: Croatiamentioning

confidence: 99%

Epidemiology of hepatitis E in South-East Europe in the "One Health" concept

Mrzljak¹,

Dinjar-Kujundzic²,

Jemeršić³

et al. 2019

WJG

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The significance of hepatitis E virus (HEV) as an important public health problem is rising. Until a decade ago, cases of HEV infection in Eur-ope were mainly confined to returning travelers, but nowadays, hepatitis E represents an emerging zoonotic infection in many European countries. The aim of this manuscript is to perform a systematic review of the published literature on hepatitis E distribution in humans, animals and environmental samples ("One Health" concept) in the South-Eastern European countries. Comparison of the available data showed that the anti-HEV seroprevalence in the South-Eastern Europe varies greatly, depending on the population studied, geographical area and methods used. The IgG seroprevalence rates in different population groups were found to be 1.1%-24.5% in Croatia, up to 20.9% in Bulgaria, 5.9-%17.1% in Romania, 15% in Serbia, up to 9.7% in Greece and 2%-9.7% in Albania. Among possible risk factors, older age was the most significant predictor for HEV seropositivity in most studies. Higher seroprevalence rates were found in animals. HEV IgG antibodies in domestic pigs were detected in 20%-54.5%, 29.2%-50%, 38.94%-50% and 31.1%-91.7% in Serbia, Bulgaria, Romania and Croatia, respectively. In wild boars seroprevalence rates were up to 10.3%, 30.3% and 31.1% in Romania, Slovenia and Croatia, respectively. A high HEV RNA prevalence in wild boars in some countries (Croatia and Romania) indicated that wild boars may have a key role in the HEV epidemiology. There are very few data on HEV prevalence in environmental samples. HEV RNA was detected in 3.3% and 16.7% surface waters in Slovenia and Serbia, respectively. There is no evidence of HEV RNA in sewage systems in this region. The available data on genetic characterization show that human, animal and environmental HEV strains mainly belong to the genotype 3.

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Differences in hepatitis E virus (HEV) presence in naturally infected seropositive domestic pigs and wild boars - an indication of wild boars having an important role in HEV epidemiology

Cited by 20 publications

References 27 publications

Seroprevalence of hepatitis E in pigs and wild boars in the region of the city Belgrade

Seroprevalence of hepatitis E in pigs and wild boars in the region of the city Belgrade

High Seroprevalence of Hepatitis E Virus Infection Among East Balkan Swine (Sus scrofa) in Bulgaria: Preliminary Results

Epidemiology of hepatitis E in South-East Europe in the "One Health" concept

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