Differences in Keratoconus as a Function of Gender

Fink, Barbara A.; Wagner, Heidi; Steger-May, Karen; Rosenstiel, Carol E.; Roediger, Teresa A.; McMahon, Timothy T.; Gordon, Mae O.; Zadnik, Karla

doi:10.1016/j.ajo.2005.03.078

Cited by 77 publications

(75 citation statements)

References 33 publications

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“…In the stratified analysis and univariate logistic regression for gender, females were twice as likely to report a positive family history. This observation was previously published by the CLEK Study Group 23. Although it is possible that females have a greater predisposition to disease, this may simply be a reporting bias.…”

Section: Discussionsupporting

confidence: 59%

“…Although it is possible that females have a greater predisposition to disease, this may simply be a reporting bias. Gender was also considered a confounder because previous reports describe differences in KC disease severity between males and females, when measured by visual acuity and certain slit-lamp signs 23. In the stratified and univariate logistic regression for race, Caucasians were 72% more likely to have a self-reported family history as compared with African–Americans.…”

Section: Discussionmentioning

confidence: 99%

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Disease severity and family history in keratoconus

Szczotka-Flynn

Slaughter

McMahon

et al. 2008

British Journal of Ophthalmology

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Disease severity and family history in keratoconus

Szczotka-Flynn

Slaughter

McMahon

et al. 2008

British Journal of Ophthalmology

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“…Women were more likely than men to report ocular symptoms of dryness and complaints based upon a composite score of ocular symptoms. Gender differences may exist in patient history, vision, and ocular symptoms in keratoconus patients [25]. …”

Section: Discussionmentioning

confidence: 99%

Vision Related Quality of Life in Patients with Keratoconus

Kurna

Altun

Gencaga

et al. 2014

Journal of Ophthalmology

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Purpose. The purpose of this study is to evaluate the vision related quality of life in patients with keratoconus by using the National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25). Methods. Thirty patients presented with keratoconus (keratoconus group) and 30 healthy patients (control group) were included in this study. Twenty patients were using rigid gas permeable and 10 patients were not using contact lenses in keratoconus group. High and low contrast visual acuity and mean K values of the patients were recorded. Each subject completed the 25-item NEI-VFQ-25. Results. All subscales of NEI-VFQ-25 were lower in the keratoconus patients. The difference was more evident in the subscales of general vision, ocular pain, near vision, vision-specific mental health, vision-specific role difficulties, and peripheral vision (P < 0.05). Overall composite score was 75.2 ± 17.2 in the keratoconus group and 93.2 ± 5.6 in the control group (P = 0.00). Contact lens wearers had higher best corrected visual acuity in comparison with noncontact lens wearers (P = 0.028). Patients with low visual acuity (logMAR > 0.4) in the better eye had lower distance vision, social functioning, mental health, and role difficulties. Meanwhile, patients with low visual acuity (logMAR > 0.4) in the worse eye had lower general health scores (P < 0.05). Conclusions. Vision related quality of life was worse in keratoconus patients. Success in the contact lens usage and maintaining higher visual acuity may improve vision related quality of life.

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“…In the CLEK study, it was found that women had made more visits to their eye care practitioner in the previous 12 months. 15 This difference could increase the chance of female representation in that study although more men were nevertheless enrolled. If the same tendency for women to make more visits to their eye care practitioner was a factor in the findings from other studies, then the same bias toward understating male representation among KC patients could also apply to them.…”

Section: Gender Biasmentioning

confidence: 98%

Quo Vadis Older Keratoconus Patients? Do They Die at Younger Ages?

McMonnies

2013

Cornea

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An absence or loss of older KC patients has been found in some specialist contact lens fitting practices. Notwithstanding the possible influence of numerous other issues, the absence or loss of KC patients may be because of reduced life expectancy, a topic that seems to warrant further examination. There may be implications for improving the understanding of the pathogenesis of KC if reduced life expectancy can be confirmed and the associated reasons elucidated.

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Differences in Keratoconus as a Function of Gender

Cited by 77 publications

References 33 publications

Disease severity and family history in keratoconus

Disease severity and family history in keratoconus

Vision Related Quality of Life in Patients with Keratoconus

Quo Vadis Older Keratoconus Patients? Do They Die at Younger Ages?

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