Differences in learning rates for item and associative memories between amnestic mild cognitive impairment and healthy controls

Wang, Pengyun; Li, Juan; Li, Huijie; Zhang, Shouzi

doi:10.1186/1744-9081-9-29

Cited by 22 publications

(20 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although this may restrict our conclusions to results on CVLT‐II, we will argue that it may also represent a strength: the scores were expected to tap the same cognitive domain and to have the same sensitivity and level of difficulty, which may be difficult to obtain when using tests from different test‐batteries and traditions. Although we showed that CVLT‐II was sensitive to age‐related cognitive changes, information about other aspects of memory function (see Wang, Li, Li & Zhang, ), attention and executive function (Reinvang, Deary, Fjell, Steen, Espeseth & Parasuraman, , Reinvang et al . ) are of importance before concluding about cognitive change in an individual.…”

Section: Discussionmentioning

confidence: 86%

Age and sex related changes in episodic memory function in middle aged and older adults

Lundervold

Wollschläger

Wehling

2014

Scandinavian J Psychology

View full text Add to dashboard Cite

Age-related change in episodic memory function is commonly reported in older adults. When detected on neuropsychological tests, it may still be difficult to distinguish normal from pathological changes. The present study investigates age-and sex-related changes in a group of healthy middle-aged and older adults, participating in a three-wave study on cognitive aging. The California Verbal Learning test (CVLT-II) was used to assess their episodic memory function. A cross-sectional analysis of results from the first wave showed higher performance in females than males, with a steeper age-related decline in males. This was confirmed in a longitudinal analysis using a mixed effects regression model, but with a lower age-related change and smaller difference between the sexes. Information about learning strategies and errors in the third wave turned out to contribute significantly to explain change in episodic memory function across the three waves. We argue that the results from the longitudinal analyses are generalizable to the population of healthy middle-aged and older individuals, and that they could be useful in guiding clinicians when evaluating individuals with respect to cognitive change.

show abstract

Section: Discussionmentioning

confidence: 86%

Age and sex related changes in episodic memory function in middle aged and older adults

Lundervold

Wollschläger

Wehling

2014

Scandinavian J Psychology

View full text Add to dashboard Cite

show abstract

“…We measured participants’ associative memory using the paired-associative learning test (PALT). The PALT is a standardized neuropsychological assessment specifically designed to evaluate associative memory in Chinese (Xu and Wu, 1986; Huo et al, 2014), and has been widely used in previous studies due to its high validity and reliability (Wang et al, 2013; Zheng et al, 2015). The test is designed as a study-test paradigm in which the participants study six novel and six semantically related word pairs and are asked to perform a cued recall test.…”

Section: Introductionmentioning

confidence: 99%

Sex Matters: Hippocampal Volume Predicts Individual Differences in Associative Memory in Cognitively Normal Older Women but Not Men

Zheng

Li²,

Xiao

et al. 2017

Front. Hum. Neurosci.

Self Cite

View full text Add to dashboard Cite

The hippocampus plays a prominent role in associative memory by supporting relational binding and recollection processes. Structural atrophy in the hippocampus is likely to induce associative memory deficits in older adults. Previous studies have primarily focused on average age-related differences in hippocampal structure and memory performance. To date, however, it remains unclear whether individual differences in hippocampal morphometry underlie differential associative memory performance, and whether there are sex differences in the structural correlates of associative memory in healthy older adults. Here, we used voxel-based morphometry (VBM) to examine the extent to which gray matter volume (GMV) of the hippocampus predicts associative memory performance in cognitively normal older adults. Seventy-one participants completed a cued recall paired-associative learning test (PALT), which consists of novel associations and semantically related associations, and underwent magnetic resonance imaging (MRI). We observed worse associative memory performance and larger variability for novel associations than for semantically related associations. The VBM results revealed that higher scores on associative memory for novel associations were related to greater hippocampal GMV across all older adults. When considering men and women separately, the correlation between hippocampal GMV and associative memory performance for novel associations reached significance only in older women. These findings suggest that hippocampal structural volumes may predict individual differences in novel associative memory in older women but not men.

show abstract

“…Recent evidence points to rate of learning as a key feature of aMCI and early onset dementia (Hanseeuw et al, 2011;Walsh et al, 2014); whilst Wang, Li, Li and Zhang (2013) have identified a key variable under conditions using massed trials in aMCI: the impairment in encoding into memory of successive items. Alternatively, it may be acknowledged that memory precision gets worse with age.…”

Section: Time Manages Interference 23mentioning

confidence: 99%

Time manages interference in visual short-term memory

Smith

McKeown

Bunce

2017

Memory

View full text Add to dashboard Cite

Emerging evidence suggests that age-related declines in memory may reflect a failure in pattern separation, a process that is believed to reduce the encoding overlap between similar stimulus representations during memory encoding. Indeed, behavioural pattern separation may be indexed by a visual continuous recognition task in which items are presented in sequence and observers report for each whether it is novel, previously viewed (old), or whether it shares features with a previously viewed item (similar). In comparison to young adults, older adults show a decreased pattern separation when the number of items between 'old' and 'similar' items is increased. Yet the mechanisms of forgetting underpinning this type of recognition task are yet to be explored in a cognitively homogenous group, with careful control over the parameters of the task, including elapsing time (a critical variable in models of forgetting). By extending the inter-item intervals, number of intervening items, and overall decay interval, we observed in a young adult sample (N=35, Mage=19.56years) that the critical factor governing performance was inter-item interval. We argue that tasks using behavioural continuous recognition to index pattern separation in immediate memory will benefit from generous inter-item spacing, offering protection from inter-item interference.

show abstract

Differences in learning rates for item and associative memories between amnestic mild cognitive impairment and healthy controls

Cited by 22 publications

References 39 publications

Age and sex related changes in episodic memory function in middle aged and older adults

Age and sex related changes in episodic memory function in middle aged and older adults

Sex Matters: Hippocampal Volume Predicts Individual Differences in Associative Memory in Cognitively Normal Older Women but Not Men

Time manages interference in visual short-term memory

Contact Info

Product

Resources

About