Differences in levels of albumin, ALT, AST, γ-GT and creatinine in frail, moderately healthy and healthy elderly individuals

Edvardsson, Maria; Sund‐Levander, Märtha; Milberg, Anna; Wressle, Ewa; Marcusson, Jan; Grodzinsky, Ewa

doi:10.1515/cclm-2017-0311

Cited by 15 publications

(15 citation statements)

References 22 publications

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“…Hypoalbuminemia is known to be more prevalent in elderly individuals who are frail compared with those who are healthy. In healthy elderly males, high CRP level and hypoalbuminemia increased the risk of early death (42). A higher GPS value was associated with elderly age in our study; however, elderly age and higher GPS values were independent predicting factors for mortality in patients with TB pleurisy.…”

Section: Discussioncontrasting

confidence: 50%

Clinical significance of Glasgow Prognostic Score in patients with tuberculous pleurisy

et al. 2018

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Background: The Glasgow Prognostic Score (GPS) reflects the host systemic inflammatory response and is a validated, independent prognostic factor for various malignancies. We investigated the clinical significance of the GPS in patients with tuberculosis (TB) pleurisy, focusing on treatment outcomes including paradoxical response (PR). Methods: This was a retrospective study performed between January 2010 and December 2015 in two referral and university hospitals in South Korea, with intermediate incidences of TB. In all, 462 patients with TB pleurisy were registered in the study. The patients were classified into three groups based on GPS score, as follows: (I) GPS of 2, elevated CRP level (>1.0 mg/dL) and hypoalbuminemia (<3.5 g/dL); (II) GPS of 1, elevated CRP level or hypoalbuminemia; and (III) GPS of 0, neither elevated CRP level nor hypoalbuminemia. Results: A total of 367 patients with TB pleurisy were finally included. PR occurred in 102 (27.8%) patients after a mean of 75 days following initiation of anti-TB treatment. The proportion of PR occurrence was significantly lower in the GPS 2 group (P=0.007). Successful treatment outcomes including cure and completion were also significantly lower in the GPS 2 group (P=0.001), while all-cause mortality and TB-specific mortality were higher in the GPS 2 group (P=0.001 and <0.001, respectively). Old age over than 65 years old was an independent predicting factor for high mortality and lower PR occurrence. However, the TB relapse rate was not different among the three GPS groups. Conclusions: Higher GPS value and elderly age were identified as prognostic factors for poor outcomes in TB pleurisy and as predicting factors for lower PR occurrence. More prospective studies are needed to clarify the utility of GPS in patients with TB pleurisy.

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Section: Discussioncontrasting

confidence: 50%

Clinical significance of Glasgow Prognostic Score in patients with tuberculous pleurisy

et al. 2018

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“…ALT, ALB, TB, and γ -GT as liver markers were associated with a high risk of mortality [ 31 ] and metabolic syndrome-related diseases, such as cardiovascular diseases [ 32 ]. Edvardsson et al [ 33 ] measured the hepatic function indices of 596 healthy and frail older adult over 80 years of age; compared with healthy older individuals, frail older individuals had lower ALT but higher γ -GT. Xu [ 34 ] measured the serum ALT of 8 437 older residents aged 60 and above in Shanghai; the results showed that ALT decreased with age.…”

Section: Discussionmentioning

confidence: 99%

[Retracted] Revealing the Longevity Code of Humans with up to Extreme Longevity in Guangxi Based on Physical Examination Indicators and Personalized Biomarkers of Aging

Ren

et al. 2022

BioMed Research International

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Background. The pursuit of health and longevity is the eternal theme of humanity. Guangxi has a remarkable phenomenon of longevity in long-lived regions and ranks with the highest number of longevity villages in China, thus providing a natural advantage for health longevity research. Methods. In this study, we selected 117 natives of a longevity area in Guangxi, covering a large age range (38-118 years old) as subjects to measure peripheral leukocyte telomere length (LTL). Nineteen physical examination indicators and two inflammatory factor levels were measured. Results. Pearson’s analysis revealed a significant negative correlation between age and LTL ( r = − 0.3694 , p = 0.003 ), as well as alanine aminotransferase, albumin, total bilirubin, direct bilirubin, γ-glutamyltransferase, triglycerides, Interleukin-10, and tumor necrosis factor type-α. Systolic blood pressure and blood urea nitrogen were positively correlated with age. In addition, LTL decreased in people aged 38–89 years, and an upward trend was observed in people aged older than 90 years. Conclusions. Longevity individuals have characteristics, such as longer LTL, good hepatic function, and lower triglycerides and inflammation levels.

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“…This condition identifies a subset of older people at high risk of progressing to frailty(75). Studies characterizing frailty conditions in this person's ability to perform ADLs, and cognitive function (tested using the Mini Mental State Examination (MMSE))(78). Some researchers emphasize the importance of history taking and clinical examination in identifying frailty(79) and…”

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confidence: 99%

Circulating levels and assessment of clinical laboratory analytes, in >80-year-old, apparently healthy, moderately healthy, and frail individuals

Edvardsson

2019

Linköping University Medical Dissertations

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Differences in levels of albumin, ALT, AST, γ-GT and creatinine in frail, moderately healthy and healthy elderly individuals

Abstract: Because a group of people are at the same age, they should not be assessed the same way. To interpret results of laboratory tests in elderly is a complex task, where reference intervals are one part, but far from the only one, to take into consideration.

Cited by 15 publications

References 22 publications

Clinical significance of Glasgow Prognostic Score in patients with tuberculous pleurisy

Clinical significance of Glasgow Prognostic Score in patients with tuberculous pleurisy

[Retracted] Revealing the Longevity Code of Humans with up to Extreme Longevity in Guangxi Based on Physical Examination Indicators and Personalized Biomarkers of Aging

Circulating levels and assessment of clinical laboratory analytes, in >80-year-old, apparently healthy, moderately healthy, and frail individuals

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Differences in levels of albumin, ALT, AST, γ-GT and creatinine in frail, moderately healthy and healthy elderly individuals

Abstract: Because a group of people are at the same age, they should not be assessed the same way. To interpret results of laboratory tests in elderly is a complex task, where reference intervals are one part, but far from the only one, to take into consideration.

Cited by 15 publications

References 22 publications

Clinical significance of Glasgow Prognostic Score in patients with tuberculous pleurisy

Clinical significance of Glasgow Prognostic Score in patients with tuberculous pleurisy

[Retracted] Revealing the Longevity Code of Humans with up to Extreme Longevity in Guangxi Based on Physical Examination Indicators and Personalized Biomarkers of Aging

Circulating levels and assessment of clinical laboratory analytes, in &gt;80-year-old, apparently healthy, moderately healthy, and frail individuals

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Circulating levels and assessment of clinical laboratory analytes, in >80-year-old, apparently healthy, moderately healthy, and frail individuals