Differences in Neointima Formation between Impervious and Porous Polytetrafluoroethylene Vascular Patch Material

Wong, Peter M.T.; Hopkins, Steven P.; Vincente, David; Williams, Katrina; Macri, Nicholas P.; Berguer, Ramón

doi:10.1007/s10016-001-0163-z

Cited by 11 publications

(12 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…45 Wong et al reported that porous and impervious ePTFE vascular patches of 10 Â 15 mm 2 in size implanted in dogs for 30 and 60 days did not reveal any significant difference in terms of neointima formation and the cellular composition of the neointima. 46 These findings however used short segments of graft, in which pannus ingrowth might have played a major role. In the work of Shi et al, 18 which used a similar experimental protocol as we did, they reported that fallout-based endothelialization occurred on the lumen of impervious prostheses.…”

Section: Discussionmentioning

confidence: 99%

“…Contreras et al implanted 2‐cm long and 2‐mm ID ePTFE grafts in the rabbit common carotid artery for 8 weeks and found no effect of permeability on either patency rate or neointima formation 45. Wong et al reported that porous and impervious ePTFE vascular patches of 10 × 15 mm 2 in size implanted in dogs for 30 and 60 days did not reveal any significant difference in terms of neointima formation and the cellular composition of the neointima 46. These findings however used short segments of graft, in which pannus ingrowth might have played a major role.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Transmural communication at a subcellular level may play a critical role in the fallout based‐endothelialization of dacron vascular prostheses in canine

Zhang

Briana

Douville

et al. 2007

J Biomedical Materials Res

View full text Add to dashboard Cite

A microporous and permeable wall is important for the healing of vascular prostheses, however, the significance of its permeability to soluble substances at subcellular level has not been demonstrated. Polyester arterial prostheses were prepared in such a way that each of them contained three segments, of which at least one segment was impervious and another segment was permeable to water but impermeable to cells. Twenty graft segments were implanted in 7 dogs as a thoraco-abdominal bypass for 2 months. The prostheses were then harvested, photographed, and treated for histological and morphological studies. The low porosity graft capped by two thrombogenic segments was fully endothelialized, proving the fallout mechanism. The striking contrast with its impermeable counterpart demonstrated that a wall permeable to small substances of subcellular level was critical for the endothelial healing. A wide range of water permeabilities did not reveal advantages of high water permeable segments over low water permeable ones. Endothelial ingrowth from anastomoses was also jeopardized in the absence of wall permeability. In conclusion, transmural communication at a subcellular level may have played a critical role in the fallout based-endothelialization of arterial prostheses in canine. This highlights the potential function of perigraft cytokines and growth factors in endothelial healing.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Transmural communication at a subcellular level may play a critical role in the fallout based‐endothelialization of dacron vascular prostheses in canine

Zhang

Briana

Douville

et al. 2007

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

“…Atherosclerotic vascular disease is one of the most common causes of death and disability worldwide [1]. Vascular grafts, which are commercially available, are special tubes that serve as artificial replacements for damaged and diseased blood vessels; these grafts are mainly produced from polyesterknitted or woven fabrics [2,3] or expanded polytetrafluoroethylene (ePTFE) [4][5][6][7]. Polyethylene terephthalate (PET) is well recognised in biomedical applications because of its biocompatibility, resilience, flexibility, durability, and resistance to biodegradation and sterilisation.…”

Section: Introductionmentioning

confidence: 99%

Promising Poly(ε-caprolactone) Composite Reinforced with Weft-Knitted Polyester for Small-Diameter Vascular Graft Application

Wang

Abedalwafa

et al. 2014

Advances in Materials Science and Engineering

View full text Add to dashboard Cite

The present study was designed to improve the mechanical performance of a small-diameter vascular prosthesis made from a flexible membrane of poly(ε-caprolactone) (PCL). PCL reinforcement was achieved by embedding a tubular fabric knitted from polyethylene terephthalate (PET) yarns within the freeze-dried composite structure. The knitting density of PET fabric influenced the mechanical properties of the new vascular graft. Results showed that the composite prototype has good mechanical properties, water permeability, elastic recovery, and suture retention strength. Increases in loop density increased compressive strength and suture retention strength and decreased elastic recovery. The new composite prototype vascular graft has promising potential applications in clinics because of its excellent mechanical properties.

show abstract

“…Actually, biologic patch materials used are limited to prosthetic materials, autologous pericardium, and allogenic or xenogenic (glutaraldehyde‐fixed) pericardium 3–9. However, these patches have well‐known limitations, including infection, thrombogenicity, calcification, foreign body reaction, and the lack of growth potential 3–9. The creation of a reabsorbable and remodelable patch will be therefore very interesting in this kind of surgery.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic acid biodegradable material for reconstruction of vascular wall: A preliminary study in rats

et al. 2011

View full text Add to dashboard Cite

The objective of this preliminary study was to develop a reabsorbable vascular patch that did not require in vitro cell or biochemical preconditioning for vascular wall repair. Patches were composed only of hyaluronic acid (HA). Twenty male Wistar rats weighing 250-350 g were used. The abdominal aorta was exposed and isolated. A rectangular breach (1 mm × 5 mm) was made on vessel wall and arterial defect was repaired with HA made patch. Performance was assessed at 1, 2, 4, 8, and 16 weeks after surgery by histology and immunohistochemistry. Extracellular matrix components were evaluated by molecular biological methods. After 16 weeks, the biomaterial was almost completely degraded and replaced by a neoartery wall composed of endothelial cells, smooth muscle cells, collagen, and elastin fibers organized in layers. In conclusion, HA patches provide a provisional three-dimensional support to interact with cells for the control of their function, guiding the spatially and temporally multicellular processes of artery regeneration.

show abstract

Differences in Neointima Formation between Impervious and Porous Polytetrafluoroethylene Vascular Patch Material

Cited by 11 publications

References 3 publications

Transmural communication at a subcellular level may play a critical role in the fallout based‐endothelialization of dacron vascular prostheses in canine

Transmural communication at a subcellular level may play a critical role in the fallout based‐endothelialization of dacron vascular prostheses in canine

Promising Poly(ε-caprolactone) Composite Reinforced with Weft-Knitted Polyester for Small-Diameter Vascular Graft Application

Hyaluronic acid biodegradable material for reconstruction of vascular wall: A preliminary study in rats

Contact Info

Product

Resources

About