Differences in Photic Entrainment of Circadian Locomotor Activity Between Lean and Obese Volcano Mice (Neotomodon alstoni)

Miranda‐Anaya, Manuel; Luna-Moreno, Dalia; Carmona-Castro, Agustín; Dı́az-Muñoz, Mauricio

doi:10.5334/jcr.145

Cited by 13 publications

(3 citation statements)

References 61 publications

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“…Circadian rhythm disruption has been found to be associated with cancers and their aggressiveness. As examples, peripheral blood mononuclear cells (PBMCs) from healthy individuals had circadian oscillations while chronic myeloid leukemia did not [ 52 ], low tumor grade MCF7 cells had circadian rhythms while high tumor grade MDA-MB-231 cells were arrhythmic [ 32 ], and in models of disease progression, circadian discrepancies were observed in both breast [ 37 ] and colon carcinoma cells [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Nobiletin affects circadian rhythms and oncogenic characteristics in a cell-dependent manner

et al. 2020

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The natural product nobiletin is a small molecule, widely studied with regard to its therapeutic effects, including in cancer cell lines and tumors. Recently, nobiletin has also been shown to affect circadian rhythms via their enhancement, resulting in protection against metabolic syndrome. We hypothesized that nobiletin's anti-oncogenic effects, such as prevention of cell migration and formation of anchorage independent colonies, are correspondingly accompanied by modulation of circadian rhythms. Concurrently, we wished to determine whether the circadian and anti-oncogenic effects of nobiletin differed across cancer cell lines. In this study, we assessed nobiletin's circadian and therapeutic characteristics to ascertain whether these effects depend on cell line, which here also varied in terms of baseline circadian rhythmicity. Three cell culture models where nobiletin's effects on cell proliferation and migration have been studied previously were evaluated: U2OS (bone osteosarcoma), which possesses robust circadian rhythms; MCF7 (breast adenocarcinoma), which has weak circadian rhythms; and MDA-MB-231 (breast adenocarcinoma), which is arrhythmic. We found that circadian, migration, and proliferative effects following nobiletin treatment were subtle in the U2OS and MCF7 cells. On the other hand, changes were clear in MDA-MB-231s, where nobiletin rescued rhythmicity and substantially reduced oncogenic features, specifically two-dimensional cell motility and anchorage-independent growth. Based on these results and those previously described, we posit that the effects of nobiletin are indeed cell-type dependent, and that a positive correlation may exist between nobiletin's circadian and therapeutic effects.

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Section: Discussionmentioning

confidence: 99%

Nobiletin affects circadian rhythms and oncogenic characteristics in a cell-dependent manner

et al. 2020

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“…Adult male mice Neotomodon alstoni were born and raised in the vivarium of Science Faculty at the National Autonomous University of Mexico (UNAM), as indicated elsewhere ( 29 ). Maintenance conditions included regulated photoperiod (Light: Dark cycles 12:12, 350–500 lx, lights on at 06:00 h), and controlled room temperature (23 ± 1°C).…”

Section: Methodsmentioning

confidence: 99%

Obesity in male volcano mice Neotomodon alstoni affects the daily rhythm of metabolism and thermoregulation

Herrera-García

Pérez-Mendoza²,

Arellanes-Licea³

et al. 2022

Front. Nutr.

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The mouse N. alstoni spontaneously develops the condition of obesity in captivity when fed regular chow. We aim to study the differences in metabolic performance and thermoregulation between adult lean and obese male mice. The experimental approach included indirect calorimetry using metabolic cages for VO2 intake and VCO2 production. In contrast, the body temperature was measured and analyzed using intraperitoneal data loggers. It was correlated with the relative presence of UCP1 protein and its gene expression from interscapular adipose tissue (iBAT). We also explored in this tissue the relative presence of Tyrosine Hydroxylase (TH) protein, the rate-limiting enzyme for catecholamine biosynthesis present in iBAT. Results indicate that obese mice show a daily rhythm persists in estimated parameters but with differences in amplitude and profile. Obese mice presented lower body temperature, and a low caloric expenditure, together with lower VO2 intake and VCO2 than lean mice. Also, obese mice present a reduced thermoregulatory response after a cold pulse. Results are correlated with a low relative presence of TH and UCP1 protein. However, qPCR analysis of Ucp1 presents an increase in gene expression in iBAT. Histology showed a reduced amount of brown adipocytes in BAT. The aforementioned indicates that the daily rhythm in aerobic metabolism, thermoregulation, and body temperature control have reduced amplitude in obese mice Neotomodon alstoni.

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“…Each mouse was housed in an individual recording container (28cm×16.5cm×13cm) with a passive infrared sensor (Biotex, Kyoto, Japan) placed 17.5 cm above the floor of the container, as previously reported [14]. All detectors were connected to the computer to record mouse movement during the test.…”

Section: Methodsmentioning

confidence: 99%

Pinelliae Rhizoma Praeparatum Cum AlumineExtract: Sedative and Hypnotic Effects in Mice and Component Compounds

Lin

Nie

Song

et al. 2019

BioMed Research International

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Pinelliae Rhizoma Praeparatum Cum Alumine (PRPCA) is useful for eliminating dampness and phlegm in clinical settings, targeting the main mechanisms of insomnia as defined in traditional Chinese medicine. However, little is known regarding the sedative and hypnotic effects of PRPCA. In the present study, we examined the sedative effects of PRPCA via a locomotor activity test and aimed to determine the most appropriate concentration of PRPCA for achieving these effects. The strongest sedative effects were observed at a PRPCA concentration of 0.45 g/ml. In addition, we investigated the hypnotic effects of PRPCA and its role in promoting sleep via sleep monitoring and vigilance state analysis. PRPCA increased rapid eye movement (REM) sleep and non-REM (NREM) sleep while decreasing wakefulness. In addition, PRPCA decreased the number of bouts of wakefulness (16–32 s and 32–64 s) and increased the number of bouts of NREM sleep (128–256 s). Furthermore, we identified a total of 32 component compounds via chromatography and mass spectrometry. Hence, the current work provides valuable information regarding the sedative and hypnotic effects of PRPCA and its regulatory mechanisms in promoting sleep.

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Differences in Photic Entrainment of Circadian Locomotor Activity Between Lean and Obese Volcano Mice (Neotomodon alstoni)

Cited by 13 publications

References 61 publications

Nobiletin affects circadian rhythms and oncogenic characteristics in a cell-dependent manner

Nobiletin affects circadian rhythms and oncogenic characteristics in a cell-dependent manner

Obesity in male volcano mice Neotomodon alstoni affects the daily rhythm of metabolism and thermoregulation

Pinelliae Rhizoma Praeparatum Cum AlumineExtract: Sedative and Hypnotic Effects in Mice and Component Compounds

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