Differences in Proteins and in the Water Balance of the Lens in Nuclear and Cortical Types of Senile Cataract

Maraini, G; Mangili, Roberto

doi:10.1002/9780470720028.ch5

Cited by 15 publications

(10 citation statements)

References 21 publications

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“…In the present study water percentages were no higher in the group of immature cataractous lenses with ac-sco than in immature cataractous lenses without ac-sco, but CNaL+ and the sums of cNaL+ + CKL+ were higher in lenses with ac-sco. High cNaL+ not accompanied by high water percentages were also reported by van Heyningen (1972) and by Maraini & Mangili (1973). Duncan (1973) suggested that negatively charged macromolecules within the lens might be responsible for the fact that cNaL+ often exceeds the cNa;,+ when the sodium pump on the lens membranes fails to extrude Na+ from the lens.…”

Section: Discussionsupporting

confidence: 57%

“…Duncan (1973) suggested that negatively charged macromolecules within the lens might be responsible for the fact that cNaL+ often exceeds the cNa;,+ when the sodium pump on the lens membranes fails to extrude Na+ from the lens. The wet weights of totally opaque lenses are lower than those of clear lenses (Maraini & Mangili 1973). Therefore, the high water and low dry weight percentages of the totally opaque lenses may be due to a leak of proteins of low molecular weight from the lenses to the aqueous humour as suggested by Mach (1963), Charlton & van Heyningen (1968) and van Heyningen (1972), rather than to a gain in water.…”

Section: Discussionmentioning

confidence: 92%

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Relative Contents of Sodium, Potassium, Water and Dry Matter in Human Senile Cataractous Lenses in Relation to Anterior Capsular/Subcapsular Opacity

Klauber

Laursen

1977

Acta Ophthalmologica

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In 49 human senile cataractous lenses the sodium and potassium concentrations of the lens water as well as the water and dry weight percentages were examined. It was found justifiable to classify the lenses into three categories on the basis of correlated biomicroscopic and biochemical findings: 1. Immature cataractous lenses without anterior capsular/subcapsular opacity (ac-sco) were characterized by low CNaL+, high CKL+ and low sums of CNaL++CKL+. 2. Immature cataractous lenses with ac-sco were characterized by intermediate value of CNaL+ and CKL+, as well as high sums of CNAL++CKL+. 3. Totally opaque lenses (these lenses had 80-100% of ac-sco) were characterized by high CNaL+, low CKL+, high sums of CNaL++CKL+, high water, and low dry weight percentages. It was found that in immature cataractous lenses increasing extension of ac-sco was correlated to increasing CNAL+ and increasing ratios of CNAL+/CNAA+ as well as to decreasing CKL+ and decreasing ratios of CKL+/CKA+. The sums of CNaL++CKA+ increased. There was a correlation of the extent of ac=sco to the water and dry weight percentages of the immature senile cataractous lenses with ac-sco, viz. a negative correlation for water and a positive one for the dry weight. However, these latter two correlations may be due to chance significances, the level of significance being only greater than P greater than 0.02 in both instances. Lenses which were estimated to have larger than or equal to 30% of ac-sco were found to be more opaque than lenses with less than or equal to 25% of ac-sco.

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 92%

Relative Contents of Sodium, Potassium, Water and Dry Matter in Human Senile Cataractous Lenses in Relation to Anterior Capsular/Subcapsular Opacity

Klauber

Laursen

1977

Acta Ophthalmologica

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“…More recently, this has been confirmed through investigations into lens wet weights (Maraini & Mangili 1973) and by in vivo ultrasonic lens thickness mensurations (Babel et al 1969;Delmarcelle & Luyckx-Bacus 1971). The latter authors further included optical pachymetry of the depth of the anterior chamber and roughly examined its possible relations to biomicroscopical types of cataract.…”

mentioning

confidence: 85%

Variations of Lens Thickness in Relation to Biomicroscopic Types of Human Senile Cataract

Laursen

Fledelius

1979

Acta Ophthalmologica

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The results are reported of 38 ultrasonographic in vivo mensurations of intraindividual differences in axial thickness between a cataractous lens in one eye and a biomicroscopically clear or slightly cataractous lens (incipient deep cortical opacity) in the other. Obviously intumescent cataractous lenses were excluded. In general, the cataractous lens was thinner than the contralateral clear or slightly cataractous lens. Large decreases in lens thickness appeared in lenses with the capsule-near opacities of posterior subcapsular cataract (PSC) + anterior capsular/subcapsular opacity (ACSCO). PSC was more closely correlated to lens thinning than was ACSCO. Nuclear cataract very often occurred in thin lenses, but did not appear to cause lens thinning per se. Deep cortical opacity was not associated with lens thinning. The present results contributed to our argumentation that the decrease in lens thickness is due to a leak of lens material through the "lens membrane" beside a possible cessation of growth of the lens fibres.

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“…18 In another study, similar observations were made on the mean thickness of the lens in patients with cortical cataract or PSC, where it was found to be significantly less than that in agematched controls. 15 Mariani and Mangili 19 and Mariani and Pescatori 20 found that lenses with cortical cataracts had a lower weight than normal lenses. 20 Goldman and Favre found decreased lens thickness with cortical cataract compared with clear lenses.…”

Section: Discussionmentioning

confidence: 99%

Lens thickness of Indian eyes: impact of isolated lens opacity, age, axial length, and influence on anterior chamber depth

Praveen

Vasavada

Shah

et al. 2008

Eye

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Purpose To report relationship of age group and axial length (AL) category to lens thickness values in eyes with a clear lens or different types of isolated cataract (nuclear, cortical, and posterior subcapsular (PSC)). Further, we evaluated lens thickness values on anterior chamber depth (ACD) in these eyes. Design Observational clinic-based study. Methods An observational study of 1442 eyes of 1442 individuals (816 eyes with isolated cataract and 626 eyes with clear lens) of those above 25 years of age was evaluated. AL and lens thickness were performed with an A-scan ultrasound after dilatation of the pupil, and manual optical pachymetry was used to measure ACD after dilatation of the pupil. Main outcome measures: Lens thickness. Results Multiple regression analysis revealed that with each decade of advancement in age, the lens thickness increased by 0.155 mm (Po0.001). The difference in lens thickness after adjusting for age group and AL category was less in cortical cataract by À0.25 mm (Po0.001) and PSC by À0.29 mm (Po0.001); With advancement in AL category, lens thickness decreased by 0.004 mm (Po0.001). After adjusting for all the parameters/variables, regression analysis revealed that as lens thickness increased, there was a significant decrease in ACD (mean À0.44 mm; Po0.001). Conclusions Lens thickness was significantly greater in clear lenses when compared with isolated cataractsFgreatest with nuclear cataract and least with PSC. Age group and AL category had a significant impact on the lens thickness of both cataract and clear lens. A significant decrease in ACD was found with the increase in lens thickness.

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Differences in Proteins and in the Water Balance of the Lens in Nuclear and Cortical Types of Senile Cataract

Cited by 15 publications

References 21 publications

Relative Contents of Sodium, Potassium, Water and Dry Matter in Human Senile Cataractous Lenses in Relation to Anterior Capsular/Subcapsular Opacity

Relative Contents of Sodium, Potassium, Water and Dry Matter in Human Senile Cataractous Lenses in Relation to Anterior Capsular/Subcapsular Opacity

Variations of Lens Thickness in Relation to Biomicroscopic Types of Human Senile Cataract

Lens thickness of Indian eyes: impact of isolated lens opacity, age, axial length, and influence on anterior chamber depth

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