Differences in reactivity of paracoccidioidomycosis sera with gp43 isoforms

Souza, Monique; Gesztesi, J.-L.; Souza, Alessandra R.; Moraes, Jane Zveiter de; Lopes, José Daniel; Camargo, Zoilo Pires de

doi:10.1080/02681219780000811

Cited by 28 publications

(20 citation statements)

References 10 publications

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“…Dentre as diversas glicoproteínas de 16 à 220 kDa produzidas pelo fungo, somente a glicoproteína gp43 é reconhecida por 100% dos pacientes PCM, sendo considerada o antígeno específico do P. brasiliensis (SOUZA et al, 1997 Conti-Diaz e Rilla (1989) acreditam que o fungo pode ser encontrado em áreas de reservas florestais, bosques, próximos a rios, tendo como reservatórios naturais anfíbios, peixes e artrópodes.…”

Section: Nounclassified

Paracoccidiodomicose em animais silvestres e domésticos

et al. 2006

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A paracoccidioidomicose é a micose sistêmica mais prevalente na América Latina, principalmente no Brasil. Apesar de existirem vários estudos sobre o diagnóstico e patologia dessa micose, pouco se conhece sobre a ecologia do agente etiológico Paracoccidioides brasiliensis. Seu habitat ainda não foi determinado, mas provavelmente o fungo vive saprofiticamente no solo. Há também pouca informação quanto a participação de outras espécies de animais na eco-epidemiologia do fungo e os isolamentos obtidos de animais como morcego e pingüim não foram reprodutíveis. Até o presente, o fungo tem sido isolado com maior freqüência do tatu, Dasypus novencinctus. Estudos soroepidemiológicos demonstraram que a infecção é freqüente em cães, principalmente da área rural e recentemente foi relatado o primeiro caso de paracoccidiodomicose natural em cão. O papel de outras espécies de animais na eco-epidemiologia do fungo ainda não está esclarecido Palavras-chave: Paracoccidioides brasiliensis. Paracoccidiodomicose. Epidemiologia. Animais silvestres. Animais domésticos. AbstractParacoccidiodomycosis is the most prevalent systemic mycosis in Latin América, mainly in Brazil. Although many studies have been done about the pathology and diagnosis of this mycosis little is known about the eco-epidemiology of the etiological agent Paracoccidioides brasiliensis. The fungus habitat also is unknown although is thought that the fungus lives as a saprobe in soil. The participation of other animal species in P. brasiliensis ecology is poorly understood and fungus isolation from animals as bat and penguin were not reproducible. The armadillos Dasypus novencinctus probably play a role in the fungus eco-epidemiology taking into account that several isolates were obtained from these animals. Seroepidemiologic studies have shown that dogs are infected by P. brasiliensis mainly in rural areas and recently was reported the first case o natural paracoccidioidomycosis in dogs. The role of other animal species in the eco-epidemiology of P. brasiliensis remains doubtful.

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Section: Nounclassified

Paracoccidiodomicose em animais silvestres e domésticos

et al. 2006

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“…It has previously suggested that not all antigenic epitopes expressed by gp43 are equally present in all P. brasiliensis strains (14). This was checked and ruled out by immunohistochemistry studies of the patient's lesion biopsies.…”

Section: Case Reportmentioning

confidence: 99%

“…Four isoforms of gp43 have been described (9). Probing of different isolates with polyclonal animal sera has revealed strain variability regarding the isoforms, which may show differing patterns of seroreactivity (14).…”

Section: Case Reportmentioning

confidence: 99%

Atypical Serological Response Marked by a Lack of Detectable Anti-gp43 Antibodies in a Patient with Disseminated Paracoccidioidomycosis

Vidal¹,

Benard²,

Brito

et al. 2005

J Clin Microbiol

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“…Souza et al [64] tested purified gp43 isoforms from three isolates using a capture ELISA test and a number of sera from adult and juvenile PCM patients. They found that the reactivity was similar (100%) among isoforms when the capture monoclonal antibody was MAb8a, but there was a decrease in the number of positive sera from juvenile (56%) and adult (71%) cases reacting with the basic isoform when the capture antibody was MAb17c.…”

Section: Impact Of Pbgp43 Polymorphism At the Protein Levelmentioning

confidence: 99%