Differences in the dietary requirement for vitamin D among Caucasian and East African women at Northern latitude

Cashman, Kevin D.; Ritz, Christian; Adebayo, Folasade Abiola; Dowling, Kirsten G.; Itkonen, Suvi T.; Öhman, Taina; Skaffari, Essi; Saarnio, Elisa; Kiely, Máiréad; Lamberg‐Allardt, Christel

doi:10.1007/s00394-018-1775-1

Cited by 19 publications

(19 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One of our core commitments in the ODIN project was to address under-represented groups among the healthy population for whom data to base estimates for vitamin D recommendations were scarce or absent [ 5 , 6 , 7 , 8 , 9 , 10 ]; namely young children, adolescents, pregnant women and persons of ethnic minority. Thus, four 25(OH)D-vitamin D 3 dose-response RCTs were designed and implemented to estimate the dietary requirements for vitamin D to meet 25(OH)D targets of 25/30 to 50 nmol/L in most (97.5%) individuals in these subgroups, under conditions of absent or scarce UVB exposure, providing evidence on which to base dietary allowances for them [ 22 , 23 , 24 , 25 , 26 ].…”

Section: Resultsmentioning

confidence: 99%

“…In a third ODIN dose-response RCT with a similar design to those in children and adolescents, vitamin D requirements of 69 women of Finnish descent were compared with 47 East African women in Helsinki (60° N), during wintertime [ 24 , 25 ]. By way of context for this RCT, Finland has a mandatory fortification programme of fluid milk products and spreads and there is a high level of awareness of vitamin D nutrition and health among Finnish residents of all nationalities [ 24 ].…”

Section: Resultsmentioning

confidence: 99%

“…Following a dose-response intervention of 0, 10 or 20 μg/day of vitamin D 3, models adjusted for baseline differences found that dietary requirements for vitamin D to maintain wintertime 25(OH)D above 30 nmol/L were significantly higher in women of East African descent than in women of Finnish descent. For white women, 8 µg/day vitamin D 3 prevented 25(OH)D falling <30 nmol/L in winter, but 18 µg/day was needed for women of East African descent to meet this minimum threshold [ 25 ]. …”

Section: Resultsmentioning

confidence: 99%

“…For white women, 8 µg/day vitamin D 3 prevented 25(OH)D falling <30 nmol/L in winter, but 18 µg/day was needed for women of East African descent to meet this minimum threshold [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Summary Outcomes of the ODIN Project on Food Fortification for Vitamin D Deficiency Prevention

Kiely

Cashman

2018

IJERPH

Self Cite

View full text Add to dashboard Cite

Food-based solutions for optimal vitamin D nutrition and health through the life cycle (ODIN) was a cross-disciplinary, collaborative project, including 30 partners from 19 countries, which aimed to develop evidence-based solutions to prevent low vitamin D status (25-hydroxyvitamin D (25(OH)D) < 30 nmol/L) using a food-first approach. This paper provides a summary overview of some of the important ODIN outcomes and outlines some outstanding data requirements. In a study of almost 56,000 individuals, the first internationally standardised dataset of vitamin D status showed that 13% of EU residents overall, across a latitude gradient of 35° N to 69° N, had serum 25(OH)D < 30 nmol/L and 40% were < 50 nmol/L. The risk of low vitamin D status was several-fold higher among persons of ethnic minority. However, additional data from quality bio-banked sera would be required to improve these estimates. To address the question of dietary requirements for vitamin D among under-researched life-stage and population groups, four dose-response RCTs conducted in Northern Europe showed that vitamin D3 intakes of 8 and 13 μg/day prevented 25(OH)D decreasing below 30 nmol/L in white children and adolescents and 20 and 30 μg/day, respectively, achieved ≥50 nmol/L. Among white women during pregnancy, 30 μg/day is required to prevent umbilical cord 25(OH)D, representing new-born vitamin D status, below 25 nmol/L. While 8 μg/day protected white women in Finland at the 30 nmol/L cut-off, 18 μg/day was needed by women of East African descent to prevent 25(OH)D decreasing below 30 nmol/L during wintertime. Replicate RCTs are needed in young children <5 years and in school-age children, teens and pregnant women of ethnic minority. Using a series of food production studies, food-based RCTs and dietary modelling experiments, ODIN research shows that diverse fortification strategies could safely increase population intakes and prevent low vitamin D status. Building on this solid technological platform, implementation research is now warranted to scale up interventions in real-world settings to eradicate vitamin D deficiency.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…For white women, 8 µg/day vitamin D 3 prevented 25(OH)D falling <30 nmol/L in winter, but 18 µg/day was needed for women of East African descent to meet this minimum threshold [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Summary Outcomes of the ODIN Project on Food Fortification for Vitamin D Deficiency Prevention

Kiely

Cashman

2018

IJERPH

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, the amount of time that people spend in the sun in modern society is not enough to meet their vitamin D needs [7,8], especially since excessive ultraviolet radiation causes skin problems. In addition, ethnicity, latitude and body mass index also in uence vitamin D status [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

The correlation between vitamin D at birth and growth at 6 months of age in twins: from a prospective longitudinal birth cohort

Wen

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Vitamin D deficiency is a global public health issue in women and children, is associated with adverse impacts on child growth, such as rickets. However, prior studies have mainly focused on measuring vitamin D levels in singleton pregnant women and their offspring, very limited studies have revealed the prevalence of vitamin D deficiency in twin pregnant women and their offspring. The aim of this study was to investigate vitamin D levels in twin pregnant women and their neonates. We also explored the correlation of maternal vitamin D levels with neonatal outcomes and infant growth. Methods: A prospective subcohort investigation was carried out among 72 dichorionic twin pregnant mothers and their twin offspring from the Longitudinal Twin Study. Peripheral blood was collected from the mothers in the third trimester and cord blood was collected form neonates at birth to identify 25[OH]D levels. Data on the characteristics of the mothers and neonates were collected. Infant growth data and food sensitivities were also collected. Results: The average maternal 25[OH]D level was 31.78 ng/mL, with 19.4% being deficiency and 20.8% insufficiency, while the average neonatal 25[OH]D level was 15.37 ng/mL, with 99.3% being deficiency or insufficiency. A positive correlation was found between maternal and neonatal 25[OH]D levels (beta-value: 0.43, 95% CI: 0.37, 0.49). Interestingly, the higher the maternal 25[OH]D level was, the smaller the co-twins birthweight discordance (beta-value: -2.67, 95% CI: -5.11, -0.23). In addition, the infants of mothers with vitamin D deficiency were more likely to be allergic to foods at six months than those of mothers with vitamin D sufficiency. Conclusions: Twin neonates were at extremely high risk of vitamin D deficiency although their mothers’ vitamin D deficiency partially improved. Higher maternal vitamin D level was associated with smaller discordance of co-twins birthweight.Trial registration: ChiCTR-OOC-16008203

show abstract

Adaptation and co‐adaptation of skin pigmentation and vitamin D genes in native Americans

Missaggia

Reales

Cybis

et al. 2020

American J of Med Genetics Pt C

View full text Add to dashboard Cite

We carried out an exhaustive review regarding human skin color variation and how much it may be related to vitamin D metabolism and other photosensitive molecules. We discuss evolutionary contexts that modulate this variability and hypotheses postulated to explain them; for example, a small amount of melanin in the skin facilitates vitamin D production, making it advantageous to have fair skin in an environment with little radiation incidence. In contrast, more melanin protects folate from degradation in an environment with a high incidence of radiation. Some Native American populations have a skin color at odds with what would be expected for the amount of radiation in the environment in which they live, a finding challenging the so‐called “vitamin D–folate hypothesis.” Since food is also a source of vitamin D, dietary habits should also be considered. Here we argue that a gene network approach provides tools to explain this phenomenon since it indicates potential alleles co‐evolving in a compensatory way. We identified alleles of the vitamin D metabolism and pigmentation pathways segregated together, but in different proportions, in agriculturalists and hunter‐gatherers. Finally, we highlight how an evolutionary approach can be useful to understand current topics of medical interest.

show abstract

Differences in the dietary requirement for vitamin D among Caucasian and East African women at Northern latitude

Abstract: The present study adds further evidence that ethnic differences in the dietary requirement for vitamin D do exist and that dose-response vitamin D intervention studies are required in at-risk target populations specified by ethnicity.

Cited by 19 publications

References 42 publications

Summary Outcomes of the ODIN Project on Food Fortification for Vitamin D Deficiency Prevention

Summary Outcomes of the ODIN Project on Food Fortification for Vitamin D Deficiency Prevention

The correlation between vitamin D at birth and growth at 6 months of age in twins: from a prospective longitudinal birth cohort

Adaptation and co‐adaptation of skin pigmentation and vitamin D genes in native Americans

Contact Info

Product

Resources

About