Differences in the distributional pattern of CRF-, oxytocin-, and vasopressin-immunoreactive nerve fibers in the median eminence of the rat

Kawata, Mitsuhiro; Hashimoto, Kozo; Takahara, Jiro; Sano, Yutaka

doi:10.1007/bf00213803

Cited by 12 publications

(1 citation statement)

References 38 publications

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“…It is probable that the unstained gomitoli are involved in the transport of the vari¬ ous other hypothalamic regulatory factors. Indeed, there is some evidence to suggest that factors show specific distributions in the rat median eminence (Kawata et al 1983b) and the human pituitary stalk (Okon & Koch 1976). This is particularly interest¬ ing in conjunction with the organisation of the various types of hormone producing cells in the anterior lobe of the pituitary gland (Petrusz & Ordronneau 1983).…”

Section: Discussionmentioning

confidence: 97%

The distribution of immunoreactive corticotrophin-releasing factor in the human pituitary stalk

Coates¹

1985

Acta Endocrinologica

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An immunohistochemical investigation into the distribution, of immunoreactive corticotrophin-releasing factor (IR-CRF) in the adult human pituitary stalk was carried out. Histological sections of six pituitary stalks were stained by an indirect immunoperoxidase technique, using a specific primary antiserum raised against synthetic ovine CRF. It was shown that IR-CRF is present surrounding the coiled capillaries of certain gomitoli bodies. These structures form the primary capillary beds of the portal system of blood flow supplying the anterior lobe of the pituitary gland. An investigation was made into the characteristics of the cellular elements of gomitoli bodies, as little is known of these structures. Immunocytochemical methods for epithelial cells (ant i \ x=req-\ cytokeratin and anti-epithelial membrane antigen), endothelial cells (factor VIII related antigen), glial cells (glial fibrillary acid protein and S100 protein) and neuroendocrine cells (neuron specific enolase) were employed, but none were positive.The concept of hypothalamic neurosecretory regu¬ lation of anterior pituitary hormones proposed by Harris (1955) has been accepted for many years. However, it is only in the past 15 years that any of the factors involved have been identified. Cortico¬ trophin-releasing factor (CRF) is one of these neurosecretions, which stimulates the release of ACTH from the anterior lobe of the pituitary gland.

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Section: Discussionmentioning

confidence: 97%

The distribution of immunoreactive corticotrophin-releasing factor in the human pituitary stalk

Coates¹

1985

Acta Endocrinologica

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Immunohistochemical identification of neurons containing corticotropin-releasing factor in the rat hypothalamus

et al. 1983

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New concepts in the regulation of hypothalamic gonadotropin releasing hormone (GnRH) secretion

Rasmussen

1986

J Endocrinol Invest

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Differences in the distributional pattern of CRF-, oxytocin-, and vasopressin-immunoreactive nerve fibers in the median eminence of the rat

Cited by 12 publications

References 38 publications

The distribution of immunoreactive corticotrophin-releasing factor in the human pituitary stalk

The distribution of immunoreactive corticotrophin-releasing factor in the human pituitary stalk

Immunohistochemical identification of neurons containing corticotropin-releasing factor in the rat hypothalamus

New concepts in the regulation of hypothalamic gonadotropin releasing hormone (GnRH) secretion

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