Differences in the Effects of EGCG on Chromosomal Stability and Cell Growth between Normal and Colon Cancer Cells

Ni, Juan; Guo, Xihan; Wang, Han; Zhou, Tao

doi:10.3390/molecules23040788

Cited by 33 publications

(24 citation statements)

References 31 publications

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“…It is reported to present anti-cancer effects in variety of cancer cells, including lung, colorectal, prostate, stomach, liver, cervical, breast, leukemia, gastric, bladder cancers [85][86][87][88][89][90]. Among its anti-cancer activities, EGCG exhibits multiple pharmacological actions, including the suppression of cell growth, proliferation, metastasis and angiogenesis, induction of apoptosis, and enhancement of anti-cancer immunity [85,86,[91][92][93][94].…”

Section: Epigallocatechin Gallate (Egcg)mentioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer activities, including antiproliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects, as well as regulate autophagy, reverse multidrug resistance, balance immunity, and enhance chemotherapy in vitro and in vivo. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2011) on the key compounds with anti-cancer effects derived from Chinese herbal medicine (curcumin, epigallocatechin gallate, berberine, artemisinin, ginsenoside Rg3, ursolic acid, silibinin, emodin, triptolide, cucurbitacin B, tanshinone I, oridonin, shikonin, gambogic acid, artesunate, wogonin, β-elemene, and cepharanthine) in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we focused on their recently discovered and/or investigated pharmacological effects, novel mechanism of action, relevant clinical studies, and their innovative applications in combined therapy and immunomodulation. In addition, the present review has extended to describe other promising compounds including dihydroartemisinin, ginsenoside Rh2, compound K, cucurbitacins D, E, I, tanshinone IIA and cryptotanshinone in view of their potentials in cancer therapy. Up to now, the evidence about the immunomodulatory effects and clinical trials of natural anti-cancer compounds from Chinese herbal medicine is very limited, and further research is needed to monitor their immunoregulatory effects and explore their mechanisms of action as modulators of immune checkpoints.

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Section: Epigallocatechin Gallate (Egcg)mentioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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“…GTPs exhibit anticancer effects via the regulation of different cancer-related processes and factors, including DNA methylation, histone modification, micro-RNA, and proteins [ 5 , 14 , 15 , 16 , 17 ]. They also play an important role via the regulation of apoptosis, growth, invasion, and angiogenesis in various types of malignancies [ 13 , 15 , 18 , 19 ]. A recent study showed that GTPs can influence the pathological roles of not only cancer cells, but also cancer stem cells [ 17 ].…”

Section: Anticancer Effects Of Green Tea Polyphenolsmentioning

confidence: 99%

“…Various cancer-related molecules have been reported to be modulated by GTPs. In fact, many studies have reported that GTPs inhibited cell growth and induced apoptosis in various types of malignancies [ 19 , 27 , 28 ]. In addition, these polyphenols modulate the functions of various cancer-related signaling molecules.…”

Section: Anticancer Effects Of Green Tea Polyphenolsmentioning

confidence: 99%

“…GTPs were found to have no toxic effects on normal cells in the gallbladder [ 28 ]. Furthermore, 24-h treatment with 20 μg/mL and 40 μg/mL of EGCG increased the frequency of apoptotic cells in colon cancer cell lines (COLO205), while no significant changes were observed in normal colon epithelial cells (NCM460) [ 19 ]. Although green tea and its extracts have a relatively high level of safety for normal cells, it should be noted that “natural” does not always imply safety.…”

Section: Bladder Cancer and Green Teamentioning

confidence: 99%

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Anticancer Effects of Green Tea and the Underlying Molecular Mechanisms in Bladder Cancer

et al. 2018

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Green tea and green tea polyphenols (GTPs) are reported to inhibit carcinogenesis and malignant behavior in several diseases. Various in vivo and in vitro studies have shown that GTPs suppress the incidence and development of bladder cancer. However, at present, opinions concerning the anticancer effects and preventive role of green tea are conflicting. In addition, the detailed molecular mechanisms underlying the anticancer effects of green tea in bladder cancer remain unclear, as these effects are regulated by several cancer-related factors. A detailed understanding of the pathological roles and regulatory mechanisms at the molecular level is necessary for advancing treatment strategies based on green tea consumption for patients with bladder cancer. In this review, we discuss the anticancer effects of GTPs on the basis of data presented in in vitro studies in bladder cancer cell lines and in vivo studies using animal models, as well as new treatment strategies for patients with bladder cancer, based on green tea consumption. Finally, on the basis of the accumulated data and the main findings, we discuss the potential usefulness of green tea as an antibladder cancer agent and the future direction of green tea-based treatment strategies for these patients.

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“…pancreatic and colon cancer (Baek et al, 2004;Lim et al, 2006;Kürbitz et al, 2011;Cordero-Herrera et al, 2013) (Sukhthankar et al, 2010;Kuerbitz et al, 2011;Wang et al, 2011b;Lee et al, 2012;Luo et al, 2014;Fu et al, 2019) attenuating angiogenesis MPI, ACTA1, PECAM1 lung cancer (Deng et al, 2019) inhibiting metastasis CDH1/2, CSRC, ERBB2, ESR2, MAPK8, MIR138, NFKB, PTK2, SLC22A5, SNAIL1/2, TJP1, VIM, lung, colon, breast, bladder, and prostate cancer (Shimizu et al, 2005a;Punathil et al, 2008;Sen et al, 2010;Sen and Chatterjee, 2011;Deng and Lin, 2011;Ko et al, 2013;Mukherjee et al, 2014;Li et al, 2015;Huang et al, 2016b;Luo et al, 2017) promoting apoptosis and autophagy AKT1, AP1, APAF1, ATM, BAD, BAX, BCL2/L1, BIRC5, CASP2/3/8/9, CCNB1, CDC2, CDKN1A, CYC, DIABLO, EGFR, ERBB2/3, FAS, FASLG, GDF15, JNK1/2, KRAS, MAPK1/14, MLH1, MSH2, MTCO2, MYC, NFKB, PARP1, PEG2, PGE2, PIK3CA, PRKAA2, PTEN, PTK2, SP1, TP53 pancreatic, lung, colon, head and neck, breast, and bladder cancer (Shimizu et al, 2005b;Park et al, 2009;Deng and Lin, 2011;Kang et al, 2013;Cerezo-Guisado et al, 2015;Li et al, 2016;Luo et al, 2017;Huang et al, 2017;Ni et al, 2018;Gu et al, 2018;Wei et al, 2018;Lu et al, 2019) sensitizing chemotherapy ABCG2/B1, ATP7A/B, BAX, BBC3, CASP3/7/9, CDKN...…”

Section: Discussionmentioning

confidence: 99%

Mapping Pharmacological Network of Multi-Targeting Litchi Ingredients in Cancer Therapeutics

Cao

Han

et al. 2020

Front. Pharmacol.

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Considerable pharmacological studies have demonstrated that the extracts and ingredients from different parts (seeds, peels, pulps, and flowers) of Litchi exhibited anticancer effects by affecting the proliferation, apoptosis, autophagy, metastasis, chemotherapy and radiotherapy sensitivity, stemness, metabolism, angiogenesis, and immunity via multiple targeting. However, there is no systematical analysis on the interaction network of "multiple ingredients-multiple targets-multiple pathways" anticancer effects of Litchi. In this study, we summarized the confirmed anticancer ingredients and molecular targets of Litchi based on published articles and applied network pharmacology approach to explore the complex mechanisms underlying these effects from a perspective of system biology. The top ingredients, top targets, and top pathways of each anticancer function were identified using network pharmacology approach. Further intersecting analyses showed that Epigallocatechin gallate (EGCG), Gallic acid, Kaempferol, Luteolin, and Betulinic acid were the top ingredients which might be the key ingredients exerting anticancer function of Litchi, while BAX, BCL2, CASP3, and AKT1 were the top targets which might be the main targets underling the anticancer mechanisms of these top ingredients. These results provided references for further understanding and exploration of Litchi as therapeutics in cancer as well as the application of "Component Formula" based on Litchi's effective ingredients.

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Differences in the Effects of EGCG on Chromosomal Stability and Cell Growth between Normal and Colon Cancer Cells

Cited by 33 publications

References 31 publications

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Anticancer Effects of Green Tea and the Underlying Molecular Mechanisms in Bladder Cancer

Mapping Pharmacological Network of Multi-Targeting Litchi Ingredients in Cancer Therapeutics

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