Differences in the force–interval relationship of isolated human myocardium with chronic coronary artery disease with and without type 2 diabetes mellitus and the role of sarcoplasmic reticulum Ca2+-ATPase

Afanasiev, S. A.; Кондратьева, Д. С.; Kanev, Aleksandr; Kozlov, B. N.; Попов, С. В.

doi:10.1134/s0362119716060025

Cited by 2 publications

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“…In previously published articles, we have also demonstrated that in inducing the onset of DM in rats in 2 weeks after myocardial infarction stimulation, the contractile function of isolated papillary muscle remains the same like in intact animals and the level of calcium-transporting proteins of sarcoplasmic reticulum of cardiomyocytes is also comparable with the one in healthy myocardium [ 11 ]. Moreover, we revealed that isolated trabeculae of the heart of ischemic heart disease (IHD) patients with short duration of DM maintained positive rhythm inotropic response of myocardium that correlated with a higher level of Са 2+ -ATPase of sarcoplasmic reticulum (SR) in comparison with the same parameters of myocardium in IHD patients without DM [ 12 ]. Since Са 2+ -ATPase of SR is energy-dependent enzyme, the efficiency of its work depends on not only the amount of enzyme but also on the availability of energy substrate.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Type 2 Diabetes Mellitus on Long-Term Prognosis in Patients of Different Ages with Myocardial Infarction

Afanasiev¹,

Гарганеева²,

Кужелева³

et al. 2018

Journal of Diabetes Research

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The objective of the study was to assess the impact of DM2 at baseline on long-term mortality after acute myocardial infarction (MI) among different age groups. The data were taken from: “Register of Acute Myocardial Infarction.” A total of 862 patients were followed for five years after acute myocardial infarction. The primary endpoint was death from any cause. The patients were categorized into 2 groups based on their ages: group 1—comprised patients older than working age (n = 358) and group 2—comprised employable patients (n = 504). A total of 208 patients were diagnosed with both cardiovascular disease and DM2. Elderly patients with DM2 had worse prognosis and increased five-year mortality compared with patients of the same age group without DM2. Statistically significant differences in long-term outcomes were found in adult patients (p = 0.004) only in group with longer duration of diabetes, unlike the group with DM2 onset. In conclusion, Type 2 DM increased 5-year mortality rate of elderly patients with myocardial infarction. However, younger patients with both myocardial infarction and DM2 had more complications in the early post-MI period compared with patients of the same age group without DM2 but did not show any statistically significant differences in the long-term outcome.

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Section: Discussionmentioning

confidence: 99%

The Impact of Type 2 Diabetes Mellitus on Long-Term Prognosis in Patients of Different Ages with Myocardial Infarction

Afanasiev¹,

Гарганеева²,

Кужелева³

et al. 2018

Journal of Diabetes Research

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“…Для ХСН характерно рассогласование процессов электромеханического сопряжения кардиомиоцитов, обусловленное нарушением функции саркоплазматического ретикулума (СПР) и внутриклеточного обмена ионов Ca(2+). Эффективность Ca(2+)-транспортирующей системы СПР напрямую зависит от функционирования Са(2+)-АТФазы (SERCA2a), осуществляющей обратный захват ионов из миоплазмы, и рианодиновых рецепторов, освобождающих Са(2+) из СПР [3,4].…”

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Polymorphic variants of genes encoding Ca(2+)-transporting sarcoplasmic reticulum proteins in the progression of chronic heart failure

et al. 2019

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Aim. To study the association between polymorphic rs1860561 variants of Ca(2+)-ATPase SERCA2a (ATP2A2) gene and rs3766871 of ryanodine receptor (RYR2) gene and the severity of chronic heart failure (CHF).Material and methods. We determined rs1860561 and rs3766871 variants of the ATP2A2 and RYR2 genes, respectively, in 168 patients with coronary artery disease (CAD) and CHF using real-time polymerase chain reaction.Results. A statistically significant (p=0,046) decrease in the left ventricular ejection fraction in AA homozygotes of the ATP2A2 gene compared to carriers of the G allele was shown. But among GG homozygotes, patients with FC II CHF prevailed and participants with FC I CHF were less common than among patients with genotype GA (p=0,041).Conclusion. The association of the AA genotype carriage for the rs1860561 variant of the ATP2A2 gene encoding Ca(2+)-ATPase SERCA2a, with a decrease in the left ventricle ejection fraction in patients with CHF and CAD was revealed. At the same time, among the GG homozygotes, FC I CHF was the least prevalent. There was no association of the rY3766871 variant of the RYR2 gene with CHF severity.

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Differences in the force–interval relationship of isolated human myocardium with chronic coronary artery disease with and without type 2 diabetes mellitus and the role of sarcoplasmic reticulum Ca2+-ATPase

Cited by 2 publications

References 27 publications

The Impact of Type 2 Diabetes Mellitus on Long-Term Prognosis in Patients of Different Ages with Myocardial Infarction

The Impact of Type 2 Diabetes Mellitus on Long-Term Prognosis in Patients of Different Ages with Myocardial Infarction

Polymorphic variants of genes encoding Ca(2+)-transporting sarcoplasmic reticulum proteins in the progression of chronic heart failure

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