Differences in the number of arginine-vasopressin-immunoreactive neurons exist in the suprachiasmatic nuclei of house mice selected for differences in nest-building behavior

Bult, Abel; Zee, Eddy A. van der; Compaan, J.C.; Lynch, Carol Becker

doi:10.1016/0006-8993(92)90266-c

Cited by 52 publications

(26 citation statements)

References 10 publications

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“…Consistent with the inverse relationship between vasopressin levels and nest building in both Mus musculus 27 and Peromyscus (this study), intracerebroventricular administration of vasopressin into parents of the high nest-building P. polionotus inhibited nest building (Fig. 5c).…”

Section: Introductionsupporting

confidence: 86%

The genetic basis of parental care evolution in monogamous mice

Bendesky

Kwon

Lassance

et al. 2017

Nature

234

202

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Summary Parental care is essential for the survival of mammals, yet the mechanisms underlying its evolution remain largely unknown. Here we show that two sister species of mice, Peromyscus polionotus and P. maniculatus, have large and heritable differences in parental behaviour. Using quantitative genetics, we identify 12 genomic regions that affect parental care, eight of which have sex-specific effects, suggesting that parental care can evolve independently in males and females. Furthermore, some regions affect parental care broadly, whereas others affect specific behaviours, such as nest building. Of the genes linked to differences in nest-building behaviour, vasopressin is differentially expressed in the hypothalamus of the two species, with increased levels associated with less nest building. Using pharmacology in Peromyscus and chemogenetics in Mus, we show that vasopressin inhibits nest building but not other parental behaviours. Together, our results indicate that variation in an ancient neuropeptide contributes to interspecific differences in parental care.

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Section: Introductionsupporting

confidence: 86%

The genetic basis of parental care evolution in monogamous mice

Bendesky

Kwon

Lassance

et al. 2017

Nature

234

202

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“…Previously, we found a 1.5-fold larger number of SCN-AVP neurons in adult S-mice compared to B-mice [7]. Table 1.…”

Section: Discussionmentioning

confidence: 77%

“…AVP-ir in the SCN was quantified by counting the number of AVP-ir cells [7,17,44,46] and/or by optical densitometry of AVP-ir with a Quantimet 600 image analysis system [46]. Both quantitative analyses were performed ''blind'' to mouse line, condition, and circadian time point.…”

Section: Quantitative Analyses Of Avp Immunoreactivitymentioning

confidence: 99%

“…The goal of this study was to examine whether previously reported mouse strain-specific differences in the number of SCN-AVP neurons of S-and B-mice [7] are also present at different time points and whether the cause of such differences could be at the level of AVP translation or AVP release. To this end, we first quantified SCN-AVP content in vivo at four time points.…”

Section: Introductionmentioning

confidence: 99%

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Circadian dynamics of vasopressin in mouse selection lines: Translation and release in the SCN

et al. 2005

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“…The choice of mice and rabbits was based on the differences in entrainment to the LD-cycle and the number of AVP-ir neurons in the SCN between the two species. Whereas mice are exclusively nocturnal, rabbits are only predominantly nocturnal under undisturbed conditions [12][13][14][15], and AVP-ir cells in the mouse SCN seem to outnumber those in the rabbit SCN [4,37].…”

Section: Introductionmentioning

confidence: 99%

Distribution of AVP and Ca2+-dependent PKC-isozymes in the suprachiasmatic nucleus of the mouse and rabbit

Zee

Bult

1995

Brain Research

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Citation for published version (APA): Zee, E. A. V. D., & Bult, A. (1995). Distribution of AVP and Ca2+-dependent PKC-isozymes in the suprachiasmatic nucleus of the mouse and rabbit. Brain Research, 701(1), 99-107. https://doi.org/10.1016/0006-8993(95)00968-1 Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. AbstractThe suprachiasmatic nucleus (SCN) is the circadian pacemaker in mammals and contains a network of argimne-vasopressin-immunoreactive (AVP-ir) neurons. AVP-recipient cells contain the Vla class of receptors linked to phosphoinositol turnover and protein kinase C (PKC). The present study describes the localization of AVP and the four Ca2+-dependent PKC-isoforms in the mouse and rabbit SCN. An estimate of the numerical density of AVP-ir neurons at the rostral, medial, and caudal level of the SCN revealed that the mouse SCN contains more than twice the number of AVP-ir neurons than the rabbit SCN. Neurons immunostained for AVP or PKC dominated in the dorsomedial and ventrolateral aspects of the mouse SCN, while the central area of the SCN revealed only weakly stained neurons. The rabbit SCN was characterized by a more homogeneous distribution of AVP-ir and PKC-ir neurons. PKCa was the most abundantly expressed isozyme in both species, whereas the presence of the other isoforms differed (mouse: PKC a > PKC/31 > > PKC/3 II > PKCT: rabbit: PKC~ > PKC/3II > PKC7 > PKC/3I). Clear PKCy-positive neurons were only observed in the rabbit SCN, while the mouse SCN predominantly contained immunolabeled fiber tracts for this PKC isozyme. Astrocytes immunoreactive for each PKC isoform were frequently encot, ntered in the rabbit SCN, but were absent in mice. Immunofluorescence double labeling showed that numerous AVP-recipient cells in the mouse SCN were immunopositive for PKCo~, and that nearly all AVP-ir neurons express PKCo~ abundantly. These results substantiate the putative role for PKC a in vasopressinergic signal transduction in the SCN. The differential expression in degree and cell lype of the CaZ+-dependent PKC-isoforms in the mouse and rabbit SCN may be related to the differences observed in circadian timekeeping between the two species.

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Differences in the number of arginine-vasopressin-immunoreactive neurons exist in the suprachiasmatic nuclei of house mice selected for differences in nest-building behavior

Cited by 52 publications

References 10 publications

The genetic basis of parental care evolution in monogamous mice

The genetic basis of parental care evolution in monogamous mice

Circadian dynamics of vasopressin in mouse selection lines: Translation and release in the SCN

Distribution of AVP and Ca2+-dependent PKC-isozymes in the suprachiasmatic nucleus of the mouse and rabbit

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