Differences in the Quantitative Distribution of Lysine-Rich Histones in Neoplastic and Normal Tissues

Kinkade, Jr Jm

doi:10.3181/00379727-137-35741

Cited by 11 publications

(2 citation statements)

References 4 publications

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“…There is support for the concept that the lysine-rich histones in the eukaryo tic cell are important in the maintenance of the structural integrity of the nuclear DNA [12,17].…”

Section: Discussionmentioning

confidence: 99%

A Multicentered Study of Lysine Therapy in Herpes simplex Infection

Griffith

Norins

Kagan³

1978

Dermatology

101

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Lysine appears to suppress the clinical manifestations of herpesvirus infection. 45 patients with frequently recurring herpes infection were given 312–1,200 mg of lysine daily in single or multiple doses. The clinical results demonstrated a beneficial effect from supplementary lysine in accelerating recovery from herpes simplex infection and suppressing recurrence. Tissue culture studies have demonstrated an enhancing effect on viral replication when the amino acid ratio of arginine to lysine favors arginine. The opposite, preponderance of lysine to arginine, suppresses viral replication and inhibits cyto-pathogenicity of herpes simplex virus. The codons characterizing herpes simplex DNA apparently specify production of viral capsids at the expense of host cell histones.

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“…There is support for the concept that the lysine-rich histones in the eukaryo tic cell are important in the maintenance of the structural integrity of the nuclear DNA [12,17].…”

Section: Discussionmentioning

confidence: 99%

A Multicentered Study of Lysine Therapy in Herpes simplex Infection

Griffith

Norins

Kagan³

1978

Dermatology

101

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“…Second, six bands which were clearly distinguishable in tumor samples were not detectable or greatly reduced in lactating mammarY tissues (Fig. 2, opened arrows); the two that were found among low molecular weight components could be related to the tumor-specific H1 histone subfractions previously reported in hepatoma cells (31,32). Nuclear histone proteins represent nearly 60% of total chromosomal proteins (10).…”

Section: Discnssionmentioning

confidence: 98%

Comparison of nuclear proteins from DMBA-induced mammary tumors and lactating mammary glands by polyacrylamide gel electrophoresis

Dinh

Bourget

1985

Breast Cancer Res Tr

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Nuclear proteins were extracted from purified nuclei of 7,12-dimethylbenz(a)anthracene(DMBA)-induced tumors and normal mammary glands of the rat by enzymatic treatment. Of the 34 bands indicated by one-dimensional polyacrylamide gel electrophoresis of nuclear proteins, 6 appeared in high concentration in tumors but were found as traces or undetectable in normal glands; 6 others were clearly shown in the latter but were not detectable or greatly reduced in the former. Two-dimensional electrophoresis identified about 130 and 92 non-histone proteins in normal mammary and tumor cell nuclei respectively. Marked differences in spot density were noted especially in spots (M.W. X 10(-3)/pI) 100/5.7 and 200/5.5 of tumors and 28/7.1, 32/5.4, 36/5.4, 38/6.9, and 68/6.0 of normal tissue. The relationship between these nuclear proteins and the development of mammary tumors is also discussed.

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The H1 Class of Histone and Diversity in Chromosomal Structure

Hohmann

1978

Subcellular Biochemistry

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Differences in the Quantitative Distribution of Lysine-Rich Histones in Neoplastic and Normal Tissues

Cited by 11 publications

References 4 publications

A Multicentered Study of Lysine Therapy in Herpes simplex Infection

A Multicentered Study of Lysine Therapy in Herpes simplex Infection

Comparison of nuclear proteins from DMBA-induced mammary tumors and lactating mammary glands by polyacrylamide gel electrophoresis

The H1 Class of Histone and Diversity in Chromosomal Structure

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