Different Association of Manganese Superoxide Dismutase Gene Polymorphisms with Risk of Prostate, Esophageal, and Lung Cancers: Evidence from a Meta-analysis of 20,025 Subjects

Abstract

Altered expression or function of manganese superoxide dismutase (MnSOD) has been shown to be associated with cancer risk but assessment of gene polymorphisms has resulted in inconclusive data. Here a search of published data was made and 22 studies were recruited, covering 20,025 case and control subjects, for metaanalyses of the association of MnSOD polymorphisms with the risk of prostate, esophageal, and lung cancers. The data on 12 studies of prostate cancer (including 4,182 cases and 6,885 controls) showed a statistically significant association with the risk of development in co-dominant models and dominant models, but not in the recessive model. Subgroup analysis showed there was no statistically significant association of MnSOD polymorphisms with aggressive or nonaggressive prostate cancer in different genetic models. In addition, the data on four studies of esophageal cancer containing 620 cases and 909 controls showed a statistically significant association between MnSOD polymorphisms and risk in all comparison models. In contrast, the data on six studies of lung cancer with 3,375 cases and 4,050 controls showed that MnSOD polymorphisms were significantly associated with the decreased risk of lung cancer in the homozygote and dominant models, but not the heterozygote model. A subgroup analysis of the combination of MnSOD polymorphisms with tobacco smokers did not show any significant association with lung cancer risk, histological type, or clinical stage of lung cancer. The data from the current study indicated that the Ala allele MnSOD polymorphism is associated with increased risk of prostate and esophageal cancers, but with decreased risk of lung cancer. The underlying molecular mechanisms warrant further investigation.

Selenium- or Vitamin E–Related Gene Variants, Interaction with Supplementation, and Risk of High-Grade Prostate Cancer in SELECT

“…(46) Of these, SOD2 has been investigated the most with regards to prostate cancer, and several,(47-49) but not all(50) meta-analyses have reported significant associations between genetic variants in SOD2 and risk of prostate cancer, particularly for more aggressive disease. We and others have previously reported on potential interaction effects between SNPS in SOD1 , SOD2, selenoprotein or selenobinding proteins, and selenium status, and risk of aggressive prostate cancer.…”

Association between Manganese Superoxide Dismutase (MnSOD) Polymorphism and Prostate Cancer Susceptibility: A Meta-Analysis

“…However, the results have remained inconsistent or even contradictory. In addition, lack of research using different stratified analyses has prevented a comprehensive understanding of the relationship between MnSOD Val16Ala polymorphism and the risk of PCa in some recent meta-analyses (31)(32)(33)(34). Therefore, to clarify the nature of the association, a meta-analysis was conducted including all eligible articles to gather the statistical evidence.…”

Cumulative evidence for association between genetic polymorphisms and esophageal cancer susceptibility: A review with evidence from meta‐analysis and genome‐wide association studies

“…For 51 SNPs identified by meta‐analysis, 38 SNPs had statistically significant association with EC or ESCC susceptibility . Meta‐analysis results showed that there were 27 SNPs associated with increased EC or ESCC risk, whereas 11 SNPs decreased the risk of EC or ESCC risk.…”