Different Composition of the Erythropoietic Tissue in Bone Marrow, Spleen and Liver in Myelofibrosis

Sjögren, U.

doi:10.1159/000207766

Cited by 7 publications

(2 citation statements)

References 6 publications

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“…Of note, it is unlikely that these erythroid progenitor-like cells are present in the blood contaminating the analysis of CTC as erythropoiesis usually occurs in the BM, however the possibility should not be ruled out, e.g. extrameduallary erythropoiesis can occur in myelofibrosis [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Characterization of single disseminated prostate cancer cells reveals tumor cell heterogeneity and identifies dormancy associated pathways

et al. 2014

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Cancer dormancy refers to the prolonged clinical disease-free time between removal of the primary tumor and recurrence, which is common in prostate cancer (PCa), breast cancer, esophageal cancer, and other cancers. PCa disseminated tumor cells (DTC) are detected in both patients with no evidence of disease (NED) and advanced disease (ADV). However, the molecular and cellular nature of DTC is unknown. We performed a first-in-field study of single DTC transcriptomic analyses in cancer patients to identify a molecular signature associated with cancer dormancy. We profiled eighty-five individual EpCAM+/CD45− cells from the bone marrow of PCa patients with NED or ADV. We analyzed 44 DTC with high prostate-epithelial signatures, and eliminated 41 cells with high erythroid signatures and low prostate epithelial signatures. DTC were clustered into 3 groups: NED, ADV_1, and ADV_2, in which the ADV_1 group presented a distinct gene expression pattern associated with the p38 stress activated kinase pathway. Additionally, DTC from the NED group were enriched for a tumor dormancy signature associated with head and neck squamous carcinoma and breast cancer. This study provides the first clinical evidence of the p38 pathway as a potential biomarker for early recurrence and an attractive target for therapeutic intervention.

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Section: Discussionmentioning

confidence: 99%

Characterization of single disseminated prostate cancer cells reveals tumor cell heterogeneity and identifies dormancy associated pathways

et al. 2014

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“…thalassaemia; 17 where the bone marrow space has been destroyed, e.g. tumour metastases, 18 myelofibrosis 19 or in cases of bone marrow dysfunction such as myeloproliferative disorders, myelodysplastic syndromes, chronic myeloid leukaemia, 20 aplastic anaemia and in the early phase of reconstitution after bone marrow transplantation 21 . More recently there have been accounts of haematopoiesis in human adult allograft livers 22 and even in normal human adult liver 23 …”

Section: Discussionmentioning

confidence: 99%