Different Contributions of Dopamine D1 and D2 Receptor Activity to Alcohol Potentiation of Brain Stimulation Reward in C57BL/6J and DBA/2J Mice

Fish, Eric W.; DiBerto, Jeffrey F.; Krouse, Michael C.; Robinson, J. Elliott; Malanga, C. J.

doi:10.1124/jpet.114.216135

Cited by 10 publications

(9 citation statements)

References 58 publications

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“…Given that genetic background strongly influences mouse LORR (Boyce-Rustay et al, 2008; Crabbe, 2012; Crabbe, Metten, Cameron, & Wahlsten, 2005) and the mice tested by Tanchuck-Nipper and colleagues were on a C57BL/6J × 129/SvJ background (as opposed to the pure C57BL/6J background used here), a plausible explanation for this discrepancy is that sex differences in the LORR are background-dependent. This would be another interesting question to explore in follow-up work, perhaps similar to what other studies have shown reporting the influence of genetic background on response to ethanol in mice (Fish, DiBerto, Krouse, Robinson, & Malanga, 2014). Aside from this question, we found that LORR durations were significantly shortened by CIE in both males and females – consistent with the development of tolerance to this measure of intoxication (as previously reported in rats and male C57BL/6J mice [Daut et al, 2015; Walls, Macklin, & Devaud, 2012]).…”

Section: Discussionmentioning

confidence: 62%

Sex differences in the behavioral sequelae of chronic ethanol exposure

Jury

DiBerto

Kash

et al. 2017

Alcohol

Self Cite

107

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Rates of alcohol use disorders (AUDs) differ between men and women, and there is also marked variation between sexes in the effects of acute and chronic alcohol. In parallel to observations in humans, prior studies in rodents have described male/female differences across a range of ethanol-related behaviors, including ethanol drinking. Nonetheless, there remain gaps in our knowledge of the role of sex in moderating the effects of ethanol, particularly in models of chronic ethanol exposure. The goal of the current study was to assess various behavioral sequelae of exposing female C57BL/6J mice to chronic intermittent ethanol (CIE) via ethanol vapors. Following four weeks of CIE exposure, adult male and female mice were compared for ethanol drinking in a two-bottle paradigm, for sensitivity to acute ethanol intoxication (via loss of righting reflex [LORR]) and for anxiety-like behaviors in the novelty-suppressed feeding and marble burying assays. Next, adult and adolescent females were tested on two different two-bottle drinking preparations (fixed or escalating ethanol concentration) after CIE. Results showed that males and females exhibited significantly blunted ethanol-induced LORR following CIE, whereas only males showed increased anxiety-like behavior after CIE. Increased ethanol drinking after CIE was also specific to males, but high baseline drinking in females may have occluded detection of a CIE-induced effect. The failure to observe elevated drinking in females in response to CIE was also seen in females exposed to CIE during adolescence, regardless of whether a fixed or escalating ethanol-concentration two-bottle procedure was employed. Collectively, these data add to the literature on sex differences in ethanol-related behaviors and provide a foundation for future studies examining how the neural consequences of CIE might differ between males and females.

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Section: Discussionmentioning

confidence: 62%

Sex differences in the behavioral sequelae of chronic ethanol exposure

Jury

DiBerto

Kash

et al. 2017

Alcohol

Self Cite

107

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“…An additional plausible explanation is suggested by the current study and involves the lower D1 receptor levels in Drd2 +/− and Drd2 −/− C mice. D1 receptor antagonism prevents the reward potentiating effects of alcohol in the intracranial self-stimulation paradigm (Fish et al, 2014 ) and decreases ETOH seeking as well as ETOH conditioned place preference (Liu and Weiss, 2002 ; Hamlin et al, 2007 ; Chaudhri et al, 2009 ; Bahi and Dreyer, 2012 ; Pina and Cunningham, 2014 ; Sciascia et al, 2014 ; Young et al, 2014 ), while D1 agonism increases ETOH self-administration (D−souza et al, 2003 ) and ethanol-induced motor sensitization (Abrahao et al, 2011 ). Since the rewarding properties of ETOH are decreased by D1 receptor antagonism, we conclude that the lower D1 striatal receptor levels in Drd2 +/− and Drd2 −/− C mice contribute to their lower ETOH intake/preference, compared with Drd2 +/+ mice.…”

Section: Discussionmentioning

confidence: 99%

Regulation of ethanol intake under chronic mild stress: roles of dopamine receptors and transporters

Delis

Rombola

Bellezza

et al. 2015

Front. Behav. Neurosci.

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Studies have shown that exposure to chronic mild stress decreases ethanol intake and preference in dopamine D2 receptor wild-type mice (Drd2+/+), while it increases intake in heterozygous (Drd2+/−) and knockout (Drd2−/−) mice. Dopaminergic neurotransmission in the basal forebrain plays a major role in the reinforcing actions of ethanol as well as in brain responses to stress. In order to identify neurochemical changes associated with the regulation of ethanol intake, we used in vitro receptor autoradiography to measure the levels and distribution of dopamine D1 and D2 receptors and dopamine transporters (DAT). Receptor levels were measured in the basal forebrain of Drd2+/+, Drd2+/−, and Drd2−/− mice belonging to one of four groups: control (C), ethanol intake (E), chronic mild stress exposure (S), and ethanol intake under chronic mild stress (ES). D2 receptor levels were higher in the lateral and medial striatum of Drd2+/+ ES mice, compared with Drd2+/+ E mice. Ethanol intake in Drd2+/+ mice was negatively correlated with striatal D2 receptor levels. D2 receptor levels in Drd2+/− mice were the same among the four treatment groups. DAT levels were lower in Drd2+/− C and Drd2−/− C mice, compared with Drd2+/+ C mice. Among Drd2+/− mice, S and ES groups had higher DAT levels compared with C and E groups in most regions examined. In Drd2−/− mice, ethanol intake was positively correlated with DAT levels in all regions studied. D1 receptor levels were lower in Drd2+/− and Drd2−/− mice, compared with Drd2+/+, in all regions examined and remained unaffected by all treatments. The results suggest that in normal mice, ethanol intake is associated with D2 receptor-mediated neurotransmission, which exerts a protective effect against ethanol overconsumption under stress. In mice with low Drd2 expression, where DRD2 levels are not further modulated, ethanol intake is associated with DAT function which is upregulated under stress leading to ethanol overconsumption.

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“…LY341495 (0.1–0.3mg/kg) was used at a dose that improved depression-like behavior in the chronic corticosterone-treated mice ( Ago et al, 2013b ). SCH39166 (0.1–0.2mg/kg) and raclopride (0.03–0.1mg/kg) were used at doses that affected reward-related behaviors in mice ( Fish et al, 2014 ; Price and Middaugh, 2004 ).…”

Section: Methodsmentioning

confidence: 99%

The Female Encounter Test: A Novel Method for Evaluating Reward-Seeking Behavior or Motivation in Mice

Ago

Hasebe

Nishiyama

et al. 2015

IJNPPY

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Background:Reduced motivation is an important marker of psychiatric disorders, including depression. We describe the female encounter test, a novel method of evaluating reward-seeking behavior in mice.Methods:The test apparatus consists of three open chambers, formed with partitions that allow the animal to move freely from one chamber to another. A test male mouse is habituated in the apparatus, and subsequently a female and male mouse are introduced into a wire-mesh box in the left and right chamber, respectively. The time the test male mouse spends in the female or male area is measured for 10min.Results:All six strains of mice tested showed a significant preference for female encounters. The preference was observed in 7–30-week-old mice. The preference was blocked by castration of the resident male test mouse, and was not affected by the phase of the menstrual cycle of the female intruder. The preference was impaired in mouse models of depression, including social isolation-reared, corticosterone-treated, and lipopolysaccharide-treated mice. The impairment was alleviated by fluvoxamine in isolation-reared and lipopolysaccharide-treated mice, and it was improved by the metabotropic glutamate 2/3 receptor antagonist LY341495 in corticosterone-treated mice. Encounter with a female, but not male, mouse increased c-Fos expression in the nucleus accumbens shell of test male mice. Furthermore, both the preference and encounter-induced increases in c-Fos expression were blocked by dopamine D1 and D2 receptor antagonists.Conclusions:These findings indicate that motivation in adult male mice can be easily evaluated by quantitating female encounters.

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Different Contributions of Dopamine D1 and D2 Receptor Activity to Alcohol Potentiation of Brain Stimulation Reward in C57BL/6J and DBA/2J Mice

Cited by 10 publications

References 58 publications

Sex differences in the behavioral sequelae of chronic ethanol exposure

Sex differences in the behavioral sequelae of chronic ethanol exposure

Regulation of ethanol intake under chronic mild stress: roles of dopamine receptors and transporters

The Female Encounter Test: A Novel Method for Evaluating Reward-Seeking Behavior or Motivation in Mice

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