Different effects of isolation-rearing and neonatal MK-801 treatment on attentional modulations of prepulse inhibition of startle in rats

Wu, Zhemeng; Ding, Yu; Jia, Huang; Li, Liang

doi:10.1007/s00213-016-4351-5

Cited by 21 publications

(15 citation statements)

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“…However, there is a strong body of literature in mammals, particularly in laboratory rodents, demonstrating that social deprivation causes dramatic effects on behavior [ 65 , 67 , 135 ], and some of the isolation-induced changes in behavior suggest that there may be underlying alterations in auditory processing. For example, social isolation alters the prepulse inhibition of the acoustic startle response in rodents, with isolated rats and mice generally showing an attenuated effect of prepulse stimuli compared to group-housed animals [ 136 , 137 , 138 , 139 , 140 , 141 , 142 ]. While most of this work has been conducted in males, there is evidence to suggest that the effect of prepulse inhibition is also attenuated in isolated females [ 143 ].…”

Section: Social Isolation and The Auditory Systemmentioning

confidence: 99%

Silence, Solitude, and Serotonin: Neural Mechanisms Linking Hearing Loss and Social Isolation

Keesom

Hurley

2020

Brain Sciences

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For social animals that communicate acoustically, hearing loss and social isolation are factors that independently influence social behavior. In human subjects, hearing loss may also contribute to objective and subjective measures of social isolation. Although the behavioral relationship between hearing loss and social isolation is evident, there is little understanding of their interdependence at the level of neural systems. Separate lines of research have shown that social isolation and hearing loss independently target the serotonergic system in the rodent brain. These two factors affect both presynaptic and postsynaptic measures of serotonergic anatomy and function, highlighting the sensitivity of serotonergic pathways to both types of insult. The effects of deficits in both acoustic and social inputs are seen not only within the auditory system, but also in other brain regions, suggesting relatively extensive effects of these deficits on serotonergic regulatory systems. Serotonin plays a much-studied role in depression and anxiety, and may also influence several aspects of auditory cognition, including auditory attention and understanding speech in challenging listening conditions. These commonalities suggest that serotonergic pathways are worthy of further exploration as potential intervening mechanisms between the related conditions of hearing loss and social isolation, and the affective and cognitive dysfunctions that follow.

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Section: Social Isolation and The Auditory Systemmentioning

confidence: 99%

Silence, Solitude, and Serotonin: Neural Mechanisms Linking Hearing Loss and Social Isolation

Keesom

Hurley

2020

Brain Sciences

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“…The acquired emotion information leads to an attentional bias to conditioned threat-associated stimuli in both humans and laboratory animals (Du, Li, Wu, & Li, 2009;Du, Wu, & Li, 2010Koster, Crombez, Van Damme, Verschuere, & De Houwer, 2005;Lei, Luo, Qu, Jia, & Li, 2014;Pischek-Simpson, Boschen, Neumann, & Waters, 2009; Z. Wu, Ding, Jia, & Li, 2016) and modulates neural activities in the auditory cortex and amygdala in both humans and laboratory animals (Armony, Quirk, & LeDoux, 1998;Du, Wang, Zhang, Wu, & Li, 2012;Morris et al, 2001;Morris, Öhman, & Dolan, 1998; for a recent review, see Grosso, Cambiaghi, Concina, Sacco, & Sacchetti, 2015).…”

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confidence: 99%

Emotionally conditioning the target-speech voice enhances recognition of the target speech under “cocktail-party” listening conditions

Lü

Bao

Chen

et al. 2018

Atten Percept Psychophys

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Under a noisy "cocktail-party" listening condition with multiple people talking, listeners can use various perceptual/cognitive unmasking cues to improve recognition of the target speech against informational speech-on-speech masking. One potential unmasking cue is the emotion expressed in a speech voice, by means of certain acoustical features. However, it was unclear whether emotionally conditioning a target-speech voice that has none of the typical acoustical features of emotions (i.e., an emotionally neutral voice) can be used by listeners for enhancing target-speech recognition under speech-on-speech masking conditions. In this study we examined the recognition of target speech against a two-talker speech masker both before and after the emotionally neutral target voice was paired with a loud female screaming sound that has a marked negative emotional valence. The results showed that recognition of the target speech (especially the first keyword in a target sentence) was significantly improved by emotionally conditioning the target speaker's voice. Moreover, the emotional unmasking effect was independent of the unmasking effect of the perceived spatial separation between the target speech and the masker. Also, (skin conductance) electrodermal responses became stronger after emotional learning when the target speech and masker were perceptually co-located, suggesting an increase of listening efforts when the target speech was informationally masked. These results indicate that emotionally conditioning the target speaker's voice does not change the acoustical parameters of the target-speech stimuli, but the emotionally conditioned vocal features can be used as cues for unmasking target speech.

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“…The failure of differentiating looming and receding sounds in isolation-reared rats may be related to their flawed attention (Li et al, 2009;Wu et al, 2018). Previously we found that isolation rearing abolished both fear conditioning-induced PPI enhancement (Du et al, 2010;Wu et al, 2016) and perceptual spatial separation-induced PPI enhancement (Du et al, 2009;Wu et al, 2016), which indicates an impairment of attending to the prepulse with acquired salient valence. Our study further extends it to show that isolation rearing abolished their attention to intrinsic salient value of prepulse (i.e., looming sounds) without acquisition.…”

Section: Discussionmentioning

confidence: 94%

“…Among the cognitive/behavioral deficits caused by isolation rearing, attentional impairment is found in several behavioral paradigms ( Wu et al, 2018 ). For example, it has been found that isolation rearing abolished both emotional and spatial attentional enhancements of PPI ( Du et al, 2009 , 2010 ; Li et al, 2009 ; Lim et al, 2012 ; Wu et al, 2016 ), declined attentional processing to novelty ( Atmore et al, 2020 ), and impaired attentional set shifting ( McLean et al, 2010 ). As looming sounds contain an intrinsic salient value for organism to avoid danger, it is of interest to investigate how isolation rearing would preserve or abolish this intrinsic attention to approaching objects.…”

Section: Introductionmentioning

confidence: 99%

“…The second aim of this study was to investigate how isolation rearing affects auditory looming effects on attentional modulation of PPI. As previous literature documented an attentional deficit caused by isolation rearing ( Du et al, 2009 , 2010 ; Li et al, 2009 ; McLean et al, 2010 ; Lim et al, 2012 ; Wu et al, 2016 , 2018 ; Atmore et al, 2020 ), we hypothesized that isolation rearing might impair the abilities of animals to differentiate looming and receding sounds; therefore no PPI difference between the two prepulse stimuli would be observed.…”

Section: Introductionmentioning

confidence: 99%

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Looming Effects on Attentional Modulation of Prepulse Inhibition Paradigm

Bao

Liu

et al. 2021

Front. Psychol.

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In a hazardous environment, it is fundamentally important to successfully evaluate the motion of sounds. Previous studies demonstrated “auditory looming bias” in both macaques and humans, as looming sounds that increased in intensity were processed preferentially by the brain. In this study on rats, we used a prepulse inhibition (PPI) of the acoustic startle response paradigm to investigate whether auditory looming sound with intrinsic warning value could draw attention of the animals and dampen the startle reflex caused by the startling noise. We showed looming sound with a duration of 120 ms enhanced PPI compared with receding sound with the same duration; however, when both sound types were at shorter duration/higher change rate (i.e., 30 ms) or longer duration/lower rate (i.e., more than 160 ms), there was no PPI difference. This indicates that looming sound–induced PPI enhancement was duration dependent. We further showed that isolation rearing impaired the abilities of animals to differentiate looming and receding prepulse stimuli, although it did not abolish their discrimination between looming and stationary prepulse stimuli. This suggests that isolation rearing compromised their assessment of potential threats from approaching objects and receding objects.

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Different effects of isolation-rearing and neonatal MK-801 treatment on attentional modulations of prepulse inhibition of startle in rats

Abstract: Isolation rearing impairs both baseline PPI and attentional modulations of PPI, but neonatally disrupting NMDA receptor-mediated transmissions specifically impair attentional modulations of PPI. Clozapine has limited alleviating effects.

Cited by 21 publications

References 95 publications

Silence, Solitude, and Serotonin: Neural Mechanisms Linking Hearing Loss and Social Isolation

Silence, Solitude, and Serotonin: Neural Mechanisms Linking Hearing Loss and Social Isolation

Emotionally conditioning the target-speech voice enhances recognition of the target speech under “cocktail-party” listening conditions

Looming Effects on Attentional Modulation of Prepulse Inhibition Paradigm

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