Different effects of probiotic species/strains on infections in preschool children: A double-blind, randomized, controlled study

Lin, Jun Song; Chiu, Yi-Han; Lin, Nien Tsung; Chu, Chia Hsiang; Huang, Kuo Chin; Liao, Kuang‐Wen; Peng, Kou Cheng

doi:10.1016/j.vaccine.2008.11.114

Cited by 69 publications

(44 citation statements)

References 36 publications

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“…These results are in agreement with other studies in children who attend day care centers. [4][5][6][7]11 To our knowledge, this is the first study to assess the cost-effectiveness of the prophylactic use of a live bacterial supplement in healthy children with the demonstration of an economic benefit to parents and community of using L reuteri DSM 17938 to prevent diarrhea and respiratory infection in day care centers.…”

Section: Discussionmentioning

confidence: 99%

Diarrhea in Preschool Children and Lactobacillus reuteri: A Randomized Controlled Trial

et al. 2014

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OBJECTIVES: To evaluate whether daily administration of Lactobacillus reuteri DSM 17938 reduces the frequency and duration of diarrheal episodes and other health outcomes in day school children in Mexico. METHODS: Healthy children (born at term, aged 6–36 months) attending day care centers were enrolled in this randomized, double-blind, placebo-controlled trial. They received L reuteri DSM 17938 (dose 108 colony-forming unit; n = 168) or identical placebo (n = 168) by mouth, daily for 3 months, after which they were followed-up after a further 3 months without supplementation. RESULTS: Data from all children were included in the final analysis. L reuteri DSM 17938 significantly reduced the frequency and duration of episodes of diarrhea and respiratory tract infection at both 3 and 6 months (P < .05). Additionally, the number of doctor visits, antibiotic use, absenteeism from day school and parental absenteeism from work were significantly reduced in the L reuteri group (P < .05). A cost-benefit analysis revealed significant reductions in costs in the L reuteri-treated children. No adverse events related to the study product were reported. CONCLUSIONS: In healthy children attending day care centers, daily administration of L reuteri DSM 17938 had a significant effect in reducing episodes and duration of diarrhea and respiratory tract infection, with consequent cost savings for the community.

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Section: Discussionmentioning

confidence: 99%

Diarrhea in Preschool Children and Lactobacillus reuteri: A Randomized Controlled Trial

et al. 2014

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“…Lin et al conducting a study in Taiwan, found some positive reduction in illness in preschool children with a variety of probiotic supplements (Lin et al, 2009). However this study greatly differed from ours in that the participants consumed capsules for 7 months, the study was not conducted by recognized CONSORT guidelines, and a multitude of different strains were studied at once.…”

Section: Discussionmentioning

confidence: 71%

“…There is a need for controlled clinical studies on specific probiotic strains, in settings and modalities that are similar to how probiotics are consumed and used in the U.S. (Pedone et al, 1999;Hatakka et al, 2001;Weizman et al, 2005;Lin et al, 2009). Our previous studies have found that by providing an intervention in the form of a yogurt drink we greatly increase compliance, and present parents with a simple alternative to traditional probiotic supplemental pills or capsules (Merenstein et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

The study to investigate the potential benefits of probiotics in yogurt, a patient-oriented, double-blind, cluster-randomised, placebo-controlled, clinical trial

et al. 2010

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Background: Probiotic functional foods are widely advertised to consumers primarily based on probiotic supplements. Objective: Determine if consumption of yogurt containing a high dose of probiotics improves health in children ages 1-3 years attending daycare/school centers. Subjects/Methods: Double-blinded, randomized, placebo-controlled, allocation concealment clinical trial. Setting: Outpatient participants in the Washington, DC area. Participants: 182 healthy children between the age of 1 and 3 years attending daycare/ school at least 3 days a week. Intervention: Active was a strawberry yogurt-based drink supplemented with Bifidobacterium animalis ssp. lactis (B. lactis) BB-12. The placebo was indistinguishable from the active drink, differing only in absence of the probiotic BB-12. Primary objective was to determine if consumption of a probiotic-containing yogurt-based drink decreases absences due to illnesses from daycare for children ages 1-3 years. Secondary was to determine if probiotic-containing yogurtbased drink improves overall parental satisfaction due to decreased absences from work and an overall healthier child. Results: There were no significant differences in the days of missed school per group, with 51.9% in the active group and 47.1% in the placebo group missing at least 1 day of school throughout the study. Additionally, there were no differences in any secondary outcomes among the groups. Conclusions: Consumption of a yogurt-based drink delivering 10 10 CFU of Bifidobacterium animalis ssp. lactis (B. lactis) BB-12 per day did not decrease the number of days missed of school due to an illness. Additional independent research on the potential of BB-12 to reduce illness in children needs to be conducted.

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“…Children also represent a main target of studies that investigate the effects of probiotics on human health, because of the importance of limiting the spread of diseases especially during wintertime, reducing missed days at school, and decreasing the need of antibiotics [43][44][45].…”

Section: Probiotics and The Immune Responsementioning

confidence: 99%

Probiotics and health: An evidence-based review

Aureli

Capurso

Castellazzi

et al. 2011

Pharmacological Research

235

131

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a b s t r a c tThe intestinal microbiota is an ecosystem formed by a variety of ecological niches, made of several bacterial species and a very large amount of strains. The microbiota is in close contact with the intestinal mucosa or epithelial interface which is, after the respiratory area, the largest surface of the body, occupying approximately 250-400 m 2 . The physiological activities of the microbiota are manifold and are just being unraveled. Based on the observations of the multiple roles played by the microbiota in health and disease, the notion of modifying it with appropriate formulations, i.e. probiotics, is being tested in several settings.This review summarizes the current knowledge on probiotics and discusses both limitations and acquired evidence to support their use in preventive and therapeutic medicine.

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Different effects of probiotic species/strains on infections in preschool children: A double-blind, randomized, controlled study

Cited by 69 publications

References 36 publications

Diarrhea in Preschool Children and Lactobacillus reuteri: A Randomized Controlled Trial

Diarrhea in Preschool Children and Lactobacillus reuteri: A Randomized Controlled Trial

The study to investigate the potential benefits of probiotics in yogurt, a patient-oriented, double-blind, cluster-randomised, placebo-controlled, clinical trial

Probiotics and health: An evidence-based review

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