Different effects of zimelidine on the reinforcing properties of d-amphetamine and morphine on conditioned place preference in rats

Kruszewska, A; Romandini, S.; Samanin, R.

doi:10.1016/0014-2999(86)90038-5

Cited by 25 publications

(9 citation statements)

References 20 publications

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“…It was surprising to discover that the same doses that produced a CTA were also reinforcing in other paradigms (e.g., Reicher & Holman, 1977;Wise et al, 1976). Parker (1982Parker ( , 1984 demonstrated that amphetamine produces a CTA without producing aversive TR responses at doses of 3 mg/kg, which is within the range of doses that are reinforcing as assessed by the placeconditioning paradigm (e.g., Kruszewska, Romandini, & Samanin, 1986;Spyraki, Fibiger, & Phillips, 1982). Doses of fif-amphetamine between 1-5 mg/kg have consistently been reported to produce a place preference after three or four conditioning trials.…”

Section: Methodsmentioning

confidence: 99%

Taste reactivity responses elicited by reinforcing drugs: A dose-response analysis.

Parker¹

1991

Behavioral Neuroscience

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A series of 3 experiments with Sprague-Dawley rats measured taste reactivity (TR) responses elicited by sucrose that was paired on 5 occasions with various doses of d-amphetamine (0, 1, 2, 5, or 10 mg/kg), nicotine (0, 0.4, 0.8, 1.2, or 2.0 mg/kg), or morphine (0, 2, 8, 20, or 80 mg/kg). The TR responses elicited by flavors paired with each of these drugs were compared with those elicited by flavors paired with lithium. The only doses of d-amphetamine and nicotine that effectively conditioned aversive TR responses were high doses that have also been demonstrated to be incapable of producing a place preference. Extremely high doses of morphine were incapable of producing aversive TR responses. It is suggested that aversive TR responses are only produced by doses of agents that are not reinforcing in other paradigms.

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Section: Methodsmentioning

confidence: 99%

Taste reactivity responses elicited by reinforcing drugs: A dose-response analysis.

Parker¹

1991

Behavioral Neuroscience

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“…On the other hand, Figure 3B shows that although each experimental group showed a numerical increase in aversive responses (gapes, chin rubs, paw treads) across trials, significant increases were reported for only the three doses of LiCl and the highest dose of amphetamine. The pattern of performance in the amphetamine groups was predicted on the basis that the three low doses of amphetamine support conditioned place preference learning (e.g., Kruszewska, Romandini, & Samanin, 1986) whereas the 10-mg/kg dose is non-rewarding or aversive (e.g., Wall, Hinson, Schmidt, Johnston, & Streather, 1990). …”

Section: Taste Reactivity and Palatabilitymentioning

confidence: 99%

Conditioned taste aversion, drugs of abuse and palatability

Lin

Arthurs

Reilly

2014

Neuroscience & Biobehavioral Reviews

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LIN, J.-Y., J. Arthurs and S. Reilly. Conditioned taste aversion: Palatability and drugs of abuse. NEUROSCI BIOBEHAV REV XX(x) XXX-XXX, 2014. – We consider conditioned taste aversion to involve a learned reduction in the palatability of a taste (and hence in amount consumed) based on the association that develops when a taste experience is followed by gastrointestinal malaise. The present article evaluates the well-established finding that drugs of abuse, at doses that are otherwise considered rewarding and self-administered, cause intake suppression. Our recent work using lick pattern analysis shows that drugs of abuse also cause a palatability downshift and, therefore, support conditioned taste aversion learning.

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“…For example, drugs that facilitate 5-HT neurotransmission (e.g., 1-tryptophan, fluoxetine, quipazine) gnerally inhibit amphetamine intracranial self-administration (ICSA; Leccese & Lyness, 1984). Similarly, 5-HT uptake inhibition can antagonize amphetamine-induced conditioned place preference (but not morphine-induced place preference; Kruszewska, Romandini, & Saminin, 1986). Of interest, intracranial self-stimulation (ICSS) of the MFB results in increased turnover of both DA and 5-HT in the NAS (Nakahara, Ozaki, Miura, Miura, & Nagatsu, 1989).…”

Section: Role Of Serotonin In Behavioral Functionsmentioning

confidence: 99%

Modulatory role of serotonin in neural information processing: Implications for human psychopathology.

Spoont

1992

Psychological Bulletin

396

284

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Investigation of the role of 5-hydroxytryptophan (5-HT), which functions as a modulator in the central nervous system, across behavioral contexts suggests that a general principle of transmitter function may be derived that is independent of specific behaviors and specific neural loci. A functional principle of 5-HT action in neural information processing in the central nervous system is proposed. Extremes deviations in 5-HT activity result in biases in information processing that may have direct effects on behavior. Such biases may predispose to pathological conditions such as violent suicide and aggression.

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Different effects of zimelidine on the reinforcing properties of d-amphetamine and morphine on conditioned place preference in rats

Cited by 25 publications

References 20 publications

Taste reactivity responses elicited by reinforcing drugs: A dose-response analysis.

Taste reactivity responses elicited by reinforcing drugs: A dose-response analysis.

Conditioned taste aversion, drugs of abuse and palatability

Modulatory role of serotonin in neural information processing: Implications for human psychopathology.

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