Different Expression of Sialyl Tn Antigen between Polypoid and Nonpolypoid Growth Types of Advanced Colorectal Carcinoma

Abstract

Colorectal tumors can be classified based on their growth pattern into the polypoid growth type (PG-type) and nonpolypoid growth type (NPG-type). We examined sialyl Tn antigen expression in advanced colorectal carcinomas that were classified as PG-type and NPG-type cancers in order to ascertain whether or not such expression correlates with other biologically and clinically important differences. A total of 94 advanced colorectal carcinomas were examined for sialyl Tn antigen expression, which was immunohistochemically detected by the monoclonal antibody TKH2. Univariate and multivariate analyses using logistic regression models were performed. Forty carcinomas (42.6%) were negative and 54 (57.5%) were positive for sialyl Tn antigen. Eighteen carcinomas (19.2%) were of PG type and 76 (80.8%) of NPG type. NPG-type cancers had a higher proportion of positive lymph node metastasis than PG-type cancers. Furthermore, sialyl Tn antigen was less often detected in NPG-type cancers (39 of 76; 51.3%) than in PG-type cancers (15 of 18; 83.3%; p = 0.0167). Multivariate analysis showed that two variables, lymph node metastasis and sialyl Tn antigen expression in carcinoma, were independently related to tumor growth patterns, that is NPG type and PG type. These data suggest that the difference in sialyl Tn antigen expression between two kinds of tumor growth patterns of advanced colorectal carcinomas, PG type and NPG type, may reflect different biological behaviors during tumor progression.

Association between oncogenic RAS mutation and radiologic-pathologic findings in patients with primary rectal cancer

“…The authors also observed that the ATL/LTL showed a significant difference between the two groups (mutant: 0.46±0.29; wild type: 0.36±0.20; P=0.0090) (12). Our result also corresponds well with the results of previous studies showing significantly higher frequencies of KRAS mutation in CRC having a polypoid or upward growth pattern (19)(20)(21)(22). These findings suggest that KRAS mutation is associated with morphologic tumor growth patterns.…”

Correlation Analysis between Tumorous Associated Antigen Sialyl-Tn Expression and ST6GalNAc I Activity in Human Colon Adenocarcinoma

“…As regards to tumorous tissue, all authors confirm that sTn is expressed strongly in colorectal carcinomas [10, 11, 12, 13, 14, 15]. In particular, sTn expression has been considered useful for predicting survival in carcinoma tissue [10, 15]and in serum [16, 17, 18]of CRC patients.…”

“…It has been well established that colorectal adenocarcinomas showed a special positive expression of sTn antigen [10, 11, 12, 13, 14, 15]. Furthermore, the value of tissue expression as an independent predictor of poor prognosis has been well demonstrated [10, 14, 15]. Likewise, circulating sTn antigen has also been detected in the sera of colorectal cancer patients and the useful prognostic value of high preoperative serum levels has been well documented [16, 17, 18].…”

Suppression of Core 1 Gal-Transferase Is Associated with Reduction of TF and Reciprocal Increase of Tn, sialyl-Tn and Core 3 Glycans in Human Colon Cancer Cells

“…It is estimated that up to 90% of all human cancers carry these oncofetal carbohydrate antigens [27], [28], [29], [30]. Increased occurrence of these oncofetal carbohydrate structures is associated with the development and progression of various human cancers including breast [31], colon [27], [32] and pancreatic [33] cancers. Increasing evidence suggests that alteration of these oncofetal glycans may play an active role in metastasis.…”