Different Gene Expression and Activity Pattern of Antioxidant Enzymes in Bladder Cancer

Wieczorek, Edyta; Jabłonowski, Zbigniew; Tomasik, Bartłomiej; Gromadzińska, Jolanta; Jabłońska, Ewa; Konecki, Tomasz; Fendler, Wojciech; Sosnowski, Marek; Wąsowicz, Wojciech; Reszka, Edyta

doi:10.21873/anticanres.11387

Cited by 24 publications

(19 citation statements)

References 26 publications

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“…Such ROS accumulation induces cellular damage that may promote cancer development as well as its metabolic phenotype [ 13 - 15 , 27 ]. In fact, most of the studies about SOD2 expression and cancer have shown that overexpression of this enzyme is associated with the presence of metastases and poor prognosis in many malignancies, such as lymphomas [ 28 , 29 ], glioblastoma [ 30 ], bladder [ 31 ], lung [ 32 ], colorectal [ 33 ], breast [ 34 ], penile [ 35 ], gastric [ 36 ], esophageal [ 37 ] and oral cancer [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Strong SOD2 expression and HPV-16/18 positivity are independent events in cervical cancer

et al. 2018

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It is well known that persistent infection with high-risk HPV (hr-HPV), mostly HPV-16 and 18, is the main cause of cervical cancer development. Manganese superoxide dismutase (MnSOD or SOD2) are highly expressed in different neoplasia. The present study investigated SOD2 protein expression and the presence of hr-HPV types in 297 cervical samples including non-neoplastic tissue, cervical intraepithelial neoplasia grade 3 (CIN3), squamous cell carcinoma (SCC) and adenocarcinoma (ADC). Strong SOD2 expression was significantly higher in ADC (82%) than CIN3 (52%) or SCC (64%). There was no association between SOD2 expression and HPV 16 and/or 18 detection for every lesion analyzed. Binary Logist Regression revealed that strong SOD2 expression (OR: 27.50, 6.16-122.81) and HPV 16 and/or HPV 18 (OR: 12.67, 4.04-39.74) were independently more associated with CIN3 than non-neoplastic cervix. Strong SOD2 expression (OR: 3.30, 1.23-8.86) and HPV 16 and/or HPV 18 (OR: 3.51, 1.03-11.87) were independently more associated with ADC than SCC. Similar findings for SOD2 expression were observed by the Cochran Mantel-Haenszel test, controlling for HPV-16 and/or HPV 18. In conclusion, the expression of SOD2 was increased in CIN3 and SCC, and more increased in cervical ADC than in SCC. Strong SOD2 expression was statistically independent of the presence of HPV 16 and/or 18. These findings suggest that the mitochondrial antioxidant system and HPV infection could follow independent pathways in the carcinogenesis of cervical epithelium and in the differentiation to SCC or ADC of the cervix.

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Section: Discussionmentioning

confidence: 99%

Strong SOD2 expression and HPV-16/18 positivity are independent events in cervical cancer

et al. 2018

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“…In general, radiation promotes GSH synthesis [90]. Because rapamycin and everolimus can affect GSH synthesis, the use of mTOR inhibitors might increase the effectiveness of radiotherapy [91,92]. In addition to antioxidant enzymes, the NRF2-dependent xCT system could promote the radioresistance of solid tumors.…”

Section: Mtor-dependent Antioxidant Mechanism In Solidmentioning

confidence: 99%

mTOR-Mediated Antioxidant Activation in Solid Tumor Radioresistance

Woo

Lee

Jung

et al. 2019

Journal of Oncology

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Radiotherapy is widely used for the treatment of cancer patients, but tumor radioresistance presents serious therapy challenges. Tumor radioresistance is closely related to high levels of mTOR signaling in tumor tissues. Therefore, targeting the mTOR pathway might be a strategy to promote solid tumor sensitivity to ionizing radiation. Radioresistance is associated with enhanced antioxidant mechanisms in cancer cells. Therefore, examination of the relationship between mTOR signaling and antioxidant mechanism-linked radioresistance is required for effective radiotherapy. In particular, the effect of mTOR signaling on antioxidant glutathione induction by the Keap1-NRF2-xCT pathway is described in this review. This review is expected to assist in the identification of therapeutic adjuvants to increase the efficacy of radiotherapy.

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“…In addition, interactions between GPX3 and the p53-inducible gene 3 (PIG3) protein leads to activation of the apoptosis in prostate cancer cells (34). A retrospective study based on 40 BC patients reported that high GPX3 expression level in plasma might be predictive indicator for BC diagnosis and recurrence after transurethral resection (35). However, based on 405 BC samples, our results demonstrated that higher GPX3 expression level may predict an early UICC stage and better prognosis.…”

Section: Discussionmentioning

confidence: 66%

Gene Expression Profiles Identified Novel Urine Biomarkers for Diagnosis and Prognosis of High-Grade Bladder Urothelial Carcinoma

Song

Jin

et al. 2020

Front. Oncol.

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Bladder urothelial carcinoma (BC) has been identified as one of the most common malignant neoplasm worldwide. High-grade bladder urothelial carcinoma (HGBC) is aggressive with a high risk of recurrence, progression, metastasis, and poor prognosis. Therefore, HGBC clinical management is still a challenge. We performed the present study to seek new urine biomarkers for HGBC and investigate how they promote HGBC progression and thus affect the prognosis based on large-scale sequencing data. We identified the overlapped differentially expressed genes (DEGs) by combining GSE68020 and The Cancer Genome Atlas (TCGA) datasets. Subsequent receiver operating characteristic (ROC) curves, Kaplan-Meier (KM) curves, and Cox regression were conducted to test the diagnostic and prognostic role of the hub genes. Chi-square test and logistic regression were carried out to analyze the associations between clinicopathologic characteristics and the hub genes. Ultimately, we performed gene set enrichment analysis (GSEA), protein-protein interaction (PPI) networks, and Bayesian networks (BNs) to explore the underlying mechanisms by which ECM1, CRYAB, CGNL1, and GPX3 are involved in tumor progression. Immunohistochemistry based on The Human Protein Atlas and quantitative real-time polymerase chain reaction based on urine samples confirmed the downregulation and diagnostic values of the hub genes in HGBC. In conclusion, our study indicated that CRYAB, CGNL1, ECM1, and GPX3 are potential urine biomarkers of HGBC. These four novel urine biomarkers will have attractive applications to provide new diagnostic methods, prognostic predictors and treatment targets for HGBC, which could improve the prognosis of HGBC patients, if validated by further experiments and larger prospective clinical trials.

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Different Gene Expression and Activity Pattern of Antioxidant Enzymes in Bladder Cancer

Cited by 24 publications

References 26 publications

Strong SOD2 expression and HPV-16/18 positivity are independent events in cervical cancer

Strong SOD2 expression and HPV-16/18 positivity are independent events in cervical cancer

mTOR-Mediated Antioxidant Activation in Solid Tumor Radioresistance

Gene Expression Profiles Identified Novel Urine Biomarkers for Diagnosis and Prognosis of High-Grade Bladder Urothelial Carcinoma

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