Different Gestational Age Related Histogenesis of Human Foetal Liver

Abstract

Liver is an important gland of gastrointestinal tract having both exocrine and endocrine functions and it is having the extensive power of regeneration. Not only the adult liver, the foetal liver is an important organ with synthetic and haemopoietic functions. It develops as a ventral outgrowth During 3 rd week of gestational age from the gut endoderm in the region of the anterior intestinal portal. Materials and Methods:We used Total of 27 formalin Preserved dead embryos and foetuses from 5weeks to 40 Weeks of gestational age of both the sexes with relevant obstetric records available in the department of Anatomy, Viswabharathi Medical College, Penchikalapadu, Kurnool for this study.Results: In the present study a total of 27 aborted embryos and foetuses of different gestational ages of both sexes of normal and abnormal were observed (table -1). The liver specimens are categorized in to gestational age groups of 0 -12 weeks, 12 -24 weeks, 24 -36 weeks and more than 36 weeks. Conclusion:At 5-6weeks of gestational age we observed the aggregation of hepatocytes and early stage of haemopoiesis which is in agreement with literature. Delay in the Histogenesis and development of the liver cells and bile duct system leads to histopathological and developmental abnormalities gives knowledge to the clinicians during clinical procedures.

Fötal Gelişim Süresince Sığır Karaciğerinde İnterlökin-37 ve Reseptörünün İmmunohistokimyasal Lokalizasyonu

“…Prenatal dönemdeki karaciğer değişik embriyonal hücre tiplerinden (hepatositler, biliyer epitel hücreleri (kolanjiyositler), stellate hücreleri, Kupffer hücreleri ve karaciğer sinüzoidal endotel hücreleri) meydana gelmektedir. Karaciğerin fizyolojik rollerinin yerine getirebilmesi için elzem olan bu hücrelerden hepatositlerin; besinlerin taşınmasını sağlayarak fötal büyüme ve gelişim gibi yüksek öneme sahip görevleri oldukları görülmüştür (15,16).…”

Cytological, histochemical, and ultrastructural study of human foetal liver of various gestation with future implications in segmental resection: an anatomical perspective

“…In foetal life, the liver starts functioning which includes glycogen storage, decomposition of red blood cells, plasma protein synthesis, detoxification and haematopoiesis. To carry out these vital functions, the liver parenchyma must therefore be arranged in such a way so that every hepatocyte on one or more of its surfaces abuts on a passageway that connects with a duct system to carry away its exocrine secretion (bile) and abuts on a blood vessel into which it delivers its endocrine secretions [ 5 ]. These minute details about the cellular organization of liver parenchyma are really crucial during segmental resection of the liver in adult age due to hepatocellular carcinoma or cirrhosis.…”