2022
DOI: 10.12688/f1000research.127234.1
|View full text |Cite
|
Sign up to set email alerts
|

Different levels of circadian (de)synchrony ­– where does it hurt?

Abstract: A network of cellular timers ensures the maintenance of homeostasis by temporal modulation of physiological processes across the day. These so-called circadian clocks are synchronized to geophysical time by external time cues (or zeitgebers). In modern societies, natural environmental cycles are disrupted by artificial lighting, around-the-clock availability of food or shiftwork. Such contradictory zeitgeber input promotes chronodisruption, i.e., the perturbation of internal circadian rhythms, resulting in adv… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
1
1

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(1 citation statement)
references
References 215 publications
0
1
0
Order By: Relevance
“…The deletion of Bmal1 in mice, but not other clock genes, is associated with the circadian behavior pattern abolishment 20 . These central clock networks can be synchronized by environmental temporal cues, such as light, also known as Zeitgeber time (ZT; the German word for 'time giver') 21,22 . Pre-clinical and clinical evidence suggests that the abnormal expression of BMAL1 may be involved in the pathogenesis of epilepsy [23][24][25] .…”
Section: Introductionmentioning
confidence: 99%
“…The deletion of Bmal1 in mice, but not other clock genes, is associated with the circadian behavior pattern abolishment 20 . These central clock networks can be synchronized by environmental temporal cues, such as light, also known as Zeitgeber time (ZT; the German word for 'time giver') 21,22 . Pre-clinical and clinical evidence suggests that the abnormal expression of BMAL1 may be involved in the pathogenesis of epilepsy [23][24][25] .…”
Section: Introductionmentioning
confidence: 99%