Different Manifestations of Malignant Melanoma in the Breast: a Report of 12 Cases and a Review of the Literature

Kurul, Sidika; Taş, Faruk; Büyükbabanı, Nesimi; Mudun, Ayşe; Baykal, Can; Çamlıca, Hakan

doi:10.1093/jjco/hyi068

Cited by 61 publications

(64 citation statements)

References 20 publications

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“…However, a few cases thought to be melanoma primary in the breast, have been described [8,9]. In the present series, 3 patients of 27 (9%) had a primary choroidal melanoma and all were associated with a prolonged disease free interval (6, 16, and 18 years) and survival.…”

Section: Discussionmentioning

confidence: 52%

Metastatic melanoma in the breast: A report of 27 cases

et al. 2006

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Section: Discussionmentioning

confidence: 52%

Metastatic melanoma in the breast: A report of 27 cases

et al. 2006

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“…6 Metastatic breast lesions might be the first presentation clinical sign of the primary malignancy. 7 Breast metastatic lesions from extramammary origin are uncommon.…”

Section: Discussionmentioning

confidence: 99%

Breast Metastasis from a Malignant Melanoma- A Case Report

Al‐Zawi

Osayi

Eades

2017

IJRRT

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Metastatic lesions in the breast from malignant diseases originated in other primary sources are rare. Mostly arise from the contra-lateral breast. The incidence extramammary origin of the breast metastasis is 1.2-2%. The usual extra-mammary primary sites of metastasis are malignant melanoma, lung cancer and Non-Hodgkin lymphoma. In any patient who has been diagnosed with a known primary cancer, if presented with a breast lump, a metastatic breast focus should be considered. The malignant melanoma [MM] characterised by widespread dissemination but infrequently metastasizes to the breast. In this paper we report a case of 43years old female with malignant melanoma with breast metastases. Staging CT chest & abdomen, showed bilateral lung nodules and numerous subcutaneous nodules, the largest seen in the umbilical area (Figure 4). Histology of the right breast biopsy reported staining for Melan-A & HMB45 is positive ( Figures 5A-5D). No staining for Cam5.2, ER, PR, CK7 and CK20. Ki67 is 10%. Appearances and immuno-profile are consistent with metastatic malignant melanoma. Due to disease dissemination, the patient has been referred to palliative oncological treatment. DiscussionBreast melanoma could arise basically in the breast skin, primarily in breast parenchyma, metastases to breast tissue, in-transit metastases (IMs) to breast glandular tissue or metastases to the breast skin. Metastatic breast lesions might be the first presentation clinical sign of the primary malignancy.7 Breast metastatic lesions from extramammary origin are uncommon. They encounter only 2% of total breast tumours. 8The top three sites are the contra-lateral breast, lymphomas and disseminated melanoma. Other sites are ovarian, lung, and gastric malignancies in addition to carcinoids & rhabdomyosarcomas.

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“…Following confirmation of histological diagnosis, wide local excision or quadrantectomy is sufficient for surgical treatment in cases with no evidence of multiple metastatic lesions in breast (3,(9)(10)(11). Axillary dissection is possible if a clinically and pathologically positive axillary lymph node is identified (12). Malignant melanoma patients with solitary metastasis may have more favorable outcomes when compared with the ones with massively infiltrated breast.…”

Section: Discussionmentioning

confidence: 99%