Different Mechanisms of Action of Histamine in Isolated Arteries of the Dog

Abstract

1 In helically-cut strips of dog coronary, superior mesenteric, right gastro-epiploic and renal arteries contracted with prostaglandin F2X (PGF21), histamine produced a dose-related relaxation, while, in contrast, the amine caused only a contraction of cerebral arterial strips. 2 The contractile response of cerebral arteries to histamine was attenuated by chlorpheniramine (10-6M) but was unaffected by cimetidine (10-5M). Relaxant responses to histamine of coronary and renal arteries were significantly attenuated by treatment with cimetidine and to a similar extent by combined treatment with cimetidine and chlorpheniramine. Chlorpheniramine alone was ineffective. 3 In mesenteric and gastro-epiploic arteries, relaxant responses to histamine were attenuated only slightly by cimetidine. Chlorpheniramine slowed the development of histamine-induced relaxations but did not alter the magnitude of the relaxations. Combined treatment with these Hl-and H2-antagonists attenuated the histamine-induced relaxations to an appreciably greater extent than treatment with cimetidine alone. 4 It may be concluded that the cerebroarterial contraction induced by histamine is mediated through HI-receptors and the relaxations of coronary and renal arteries induced by histamine are mediated through H2-receptors. It appears that Hl-and H2-receptors interact with each other to produce potentiation of histamine-induced relaxations of mesenteric and gastro-epiploic arteries.

Inhibition of cardiac sympathetic neurotransmission by histamine in the dog is mediated by H1‐receptors

“…These results suggest that histamine-induced increases in coronary blood flow are mediated by activation of both histamine Hl-and H2-receptors. Recently, Konishi et al, (1981), using the helical strips of dog coronary artery, reported that the relaxant response to histamine was mediated by histamine H2-receptors since it was attenuated by cimetidine but was not influenced by chlorpheniramine. It is obvious that such isolated preparations consist of relatively large size vessels.…”

“…In the dog coronary circulation, however, there is little information concerning the role of histamine Hl-and H2-receptors in mediation of the vascular effects of histamine. Recently, Konishi, Toda & Yamamoto (1981) showed that relaxation of helically-cut strips of the dog coronary artery induced by histamine was mediated by histamine H2-receptors. The present study provides evidence for HI-receptor mediated prejunctional inhibition of cardiac sympathetic nerve function and for both H1-and H2-receptor mediated coronary vasodilatation.…”

Endothelium‐dependent relaxation induced by angiotensin II and histamine in isolated arteries of dog

“…Ang II in a concentration of 10-7 M or histamine in a concentration of 10-6 M was added, and after the tension had returned and stabilized, PGI2 (10-8M) and isoprenaline (10-7M) were added. The concentration of Ang II used was sufficient to produce the maximum relaxation (Toda & Miyazaki, 1981), and the concentration of histamine was approximately the median effective concentration (Konishi et al, 1981). At the end of each series of experiments, papaverine (10-4M) was added to produce the maximum relaxation (Toda, 1974); relaxations induced by Ang II, histamine, PGI2, isoprenaline or acetylcholine relative to those induced by papaverine are presented.…”

Mechanism of histamine actions in human coronary arteries.

“…In response to histamine, dog mesenteric, gastroepiploic, and renal arteries relax, 1 but dog cerebral arteries of the proximal portion, pulmonary and mesenteric arteries, and pulmonary and portal veins constrict.…”