Different Metabolic Pathways in Diabetic Kidney Disease and Recent Advances in Slowing Disease Progression

Baldha, Raj; Nayak, S P Srinivas; Pandya, Maulik Kamleshbhai; Buddhadev, Mohit; Chakraborthy, G. S.

doi:10.5281/zenodo.5641313

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Mechanisms Of Diabetic Kidney Disease1

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2023

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“…Up to 50% of all occurrences of ESRD in Western populations are caused by DKD, a serious microvascular complication of DM. [42,43]. As mentioned above, DKD is an important risk factor for cardiovascular mortality in patients, particularly when accompanied by hypertension.…”

Section: Mechanisms Of Diabetic Kidney Diseasementioning

confidence: 97%

Diabetic kidney disease: Risk factors, challenges and opportunities in the era of precision medicine

khan¹,

Nayak²,

Sen³

et al. 2023

Int. J. Biol. Pharm. Sci. Arch.

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DKD is now recognized as the primary cause of chronic and end-stage-renal disease worldwide. The disease is characterized by changes in renal function and structure, followed by a gradual decline in kidney function, leading to ESRD. Risk factors for DKD include age, sex, race/ethnicity, family history of hyperglycemia and AKI. Recent studies have shown that certain medication classes, such as SGLT-2 inhibitors, can protect the kidneys independent of diabetes control. However, there are still gaps in our understanding of DKD, and its diagnosis is subjective due to the lack of a noninvasive biomarker. This makes it challenging to design clinical trials to identify effective treatments for the disease. Our review article aims to provide information on basic mechanisms of DKD, various treatment strategies and challenges by using personalized approaches to diagnosis and prevention.

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Section: Mechanisms Of Diabetic Kidney Diseasementioning

confidence: 97%